Reactome | PCBD1 [cytosol]

PCBD1 [cytosol]

Stable Identifier

R-HSA-71131

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pterin-4-alpha-carbinolamine dehydratase, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin-4-alpha-carbinolamine dehydratase , PHS, 4-alpha- hydroxy-tetrahydropterin dehydratase, Phenylalanine hydroxylase- stimulating protein, Pterin carbinolamine dehydratase, PCD, Dimerization cofactor of hepatocyte nuclear factor 1-alpha, Dimerization cofactor of HNF1, DCoH

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
8444860	Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence. Hauer, CR, Rebrin, I, Thony, B, Neuheiser, F, Curtius, HC, Hunziker, P, Blau, N, Ghisla, S, Heizmann, CW	J Biol Chem	1993

External Reference Information

External Reference

UniProt:P61457 PCBD1

Gene Names

PCBD1, DCOH, PCBD

Chain

initiator methionine:1, chain:2-104

Reference Genes

BioGPS Gene:5092 PCBD1

COSMIC (genes):PCBD1 PCBD1

CTD Gene:5092 PCBD1

dbSNP Gene:5092 PCBD1

ENSEMBL:ENSG00000166228 PCBD1

HGNC:8646 PCBD1

KEGG:hsa:5092 PCBD1

Monarch:5092 PCBD1

NCBI Gene:5092 PCBD1

OMIM:126090 PCBD1

UCSC:P61457 PCBD1

Reference Transcript

Other Identifiers

11717354_at

16715200

203557_PM_s_at

203557_s_at

3293538

3293539

3293540

3293541

3293543

3293544

3293545

3293546

3293547

34352_at

5092

7934178

A_23_P367405

GE62801

GE79077

GO:0003713

GO:0004505

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006520

GO:0006729

GO:0008124

GO:0016491

GO:0016829

GO:0019293

GO:0042802

GO:0045893

GO:0070062

HMNXSV003009085

HMNXSV003023259

ILMN_1786105

ILMN_1795906

ILMN_1813456

L41559_at

PH_hs_0000396

TC10001369.hg

g4557830_3p_s_at

Participates

as a component of

PCBD1 tetramer [cytosol] (Homo sapiens)

Inferred To

Homologues of PCBD1 [cytosol] (Dictyostelium discoideum)

Pcbd1 [cytosol] (Mus musculus)

Pcbd1 [cytosol] (Rattus norvegicus)

PCBD1 [cytosol] (Bos taurus)

PCBD1 [cytosol] (Dictyostelium discoideum)

PCBD1 [cytosol] (Plasmodium falciparum)

PCBD1 [cytosol] (Saccharomyces cerevisiae)

PCBD1 [cytosol] (Sus scrofa)

pcbd1 [cytosol] (Danio rerio)

pcbd1 [cytosol] (Xenopus tropicalis)

pcbd [cytosol] (Dictyostelium discoideum)

Pcd [cytosol] (Drosophila melanogaster)

omt2 [cytosol] (Schizosaccharomyces pombe)

pcbd-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001276726.1, NP_000272.1

ENSEMBL

ENST00000299299, ENSP00000299299, ENSG00000166228

OpenTargets

ENSG00000166228

GeneCards

PCBD1

HPA

ENSG00000166228-PCBD1

PRO

P61457

Pharos - Targets

P61457

Orphanet

PCBD1

HMDB Protein

HMDBP02872

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35680 HNF1B	1	HNF1B [nucleoplasm] (R-HSA-3004721)	0.815	8
UniProt:Q07654 TFF3	1	TFF3 [extracellular region] (R-HSA-9017888)	0.718	6
UniProt:P20823 HNF1A	1	HNF1A [nucleoplasm] (R-HSA-3004629)	0.707	4
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.524	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.524	2

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