Reactome | NAE1 [cytosol]

NAE1 [cytosol]

Stable Identifier

R-HSA-8951449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD8-activating enzyme E1 regulatory subunit, ULA1_HUMAN, APPBP1

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External Reference Information

External Reference

UniProt:Q13564 NAE1

Gene Names

NAE1, APPBP1, HPP1

Chain

initiator methionine:, chain:2-534

Reference Genes

BioGPS Gene:8883 NAE1

COSMIC (genes):NAE1 NAE1

CTD Gene:8883 NAE1

dbSNP Gene:8883 NAE1

ENSEMBL:ENSG00000159593 NAE1

HGNC:621 NAE1

KEGG:hsa:8883 NAE1

Monarch:8883 NAE1

NCBI Gene:8883 NAE1

OMIM:603385 NAE1

UCSC:Q13564 NAE1

Reference Transcript

Other Identifiers

11717250_a_at

16827170

202268_PM_s_at

202268_s_at

35364_at

3695265

3695267

3695269

3695270

3695272

3695273

3695274

3695275

3695276

3695277

3695278

3695279

3695280

3695282

3695283

3695284

3695285

3695286

3695287

3695288

3695289

3695290

3695291

3695292

3695293

3695294

3695295

3695296

3695297

3695298

3695299

3695300

3695301

3695302

3695303

3695304

3695306

3695307

3695309

8001876

8883

A_23_P77459

GE59214

GO:0003824

GO:0004839

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006511

GO:0006915

GO:0006974

GO:0007165

GO:0008641

GO:0012501

GO:0016567

GO:0016874

GO:0019781

GO:0031625

GO:0032991

GO:0033314

GO:0042981

GO:0043226

GO:0043523

GO:0045116

GO:0046982

GO:0051402

GO:0098978

GO:0140096

GO:0140657

GO:0150052

HMNXSV003032247

ILMN_1689665

ILMN_1756308

ILMN_2415439

PH_hs_0025090

TC16001174.hg

U50939_at

g4502168_3p_a_at

Participates

as a component of

Inferred To

uba5 [cytosol] (Schizosaccharomyces pombe)

APP-BP1 [cytosol] (Drosophila melanogaster)

Ghost homologue of NAE1 [cytosol] (Sus scrofa)

nae1 [cytosol] (Danio rerio)

nae1 [cytosol] (Dictyostelium discoideum)

nae1 [cytosol] (Xenopus tropicalis)

NAE1 [cytosol] (Bos taurus)

NAE1 [cytosol] (Canis familiaris)

NAE1 [cytosol] (Gallus gallus)

NAE1 [cytosol] (Plasmodium falciparum)

ULA1 [cytosol] (Saccharomyces cerevisiae)

Nae1 [cytosol] (Mus musculus)

Nae1 [cytosol] (Rattus norvegicus)

ula-1 [cytosol] (Caenorhabditis elegans)

Cross References

OpenTargets

ENSG00000159593

ENSEMBL

ENSP00000290810, ENSP00000368776, ENSP00000351990, ENST00000394074, ENST00000359087, ENST00000379463, ENST00000290810, ENSP00000377637

HPA

ENSG00000159593-NAE1

ZINC - Substances

ULA1_HUMAN

ZINC - Biogenic

ULA1_HUMAN

ZINC target

Q13564

PRO

Q13564

Pharos - Targets

Q13564

ZINC - Predictions - Purchasable

ULA1_HUMAN

GlyGen

Q13564

PDB

1TT5, 3DBL, 1YOV, 3DBH, 2NVU, 1R4M, 1R4N, 3DBR, 3GZN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.744	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.669	7
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3

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