Reactome | NAE1 [cytosol]

NAE1 [cytosol]

Stable Identifier

R-HSA-8951449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD8-activating enzyme E1 regulatory subunit, ULA1_HUMAN, APPBP1

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External Reference Information

External Reference

UniProt:Q13564 NAE1

Gene Names

NAE1, APPBP1, HPP1

Chain

initiator methionine:1, chain:2-534

Reference Genes

BioGPS Gene:8883 NAE1

COSMIC (genes):NAE1 NAE1

CTD Gene:8883 NAE1

dbSNP Gene:8883 NAE1

ENSEMBL:ENSG00000159593 NAE1

HGNC:621 NAE1

KEGG Gene (Homo sapiens):8883 NAE1

Monarch:8883 NAE1

NCBI Gene:8883 NAE1

OMIM:603385 NAE1

UCSC:Q13564 NAE1

Reference Transcript

Other Identifiers

11717250_a_at

16827170

202268_s_at

35364_at

3695269

3695270

3695273

3695276

3695278

3695280

3695282

3695284

3695286

3695287

3695288

3695289

3695290

3695291

3695292

3695293

3695294

3695295

3695296

3695297

3695299

3695300

3695301

3695303

3695306

3695307

8001876

8883

A_23_P77459

GE59214

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006915

GO:0007049

GO:0007165

GO:0008150

GO:0008219

GO:0008641

GO:0016020

GO:0016874

GO:0019781

GO:0019899

GO:0031625

GO:0032446

GO:0032991

GO:0033314

GO:0042981

GO:0043523

GO:0043687

GO:0045116

GO:0046982

GO:0051402

ILMN_1684816

ILMN_1756308

ILMN_2415439

PH_hs_0025090

TC16001174.hg

U50939_at

g4502168_3p_a_at

Participant Of

hasComponent

Inferred To

uba5 [cytosol] (Schizosaccharomyces pombe)

APP-BP1 [cytosol] (Drosophila melanogaster)

Ghost homologue of NAE1 [cytosol] (Plasmodium falciparum)

nae1 [cytosol] (Danio rerio)

nae1 [cytosol] (Dictyostelium discoideum)

nae1 [cytosol] (Xenopus tropicalis)

NAE1 [cytosol] (Bos taurus)

NAE1 [cytosol] (Canis familiaris)

NAE1 [cytosol] (Gallus gallus)

TERB1 [cytosol] (Sus scrofa)

ULA1 [cytosol] (Saccharomyces cerevisiae)

Nae1 [cytosol] (Mus musculus)

Nae1 [cytosol] (Rattus norvegicus)

ula-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001018170.1, XP_005256272.1, NP_001018169.1, NP_003896.1, XP_011521724.1, NP_001273429.1

OpenTargets

ENSG00000159593

ZINC - Substances

ULA1_HUMAN

HPA

ENSG00000159593-NAE1

GeneCards

Q13564

ZINC target

Q13564

Ensembl

ENSG00000159593, ENSP00000377637, ENST00000394074, ENSP00000290810, ENSP00000368776, ENST00000290810, ENST00000359087, ENST00000379463, ENSP00000351990

ZINC - Biogenic

ULA1_HUMAN

PRO

Q13564

ZINC - Predictions - Purchasable

ULA1_HUMAN

PDB

3GZN, 1TT5, 2NVU, 3DBL, 3DBH, 1R4M, 1R4N, 1YOV, 3DBR

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.669	7
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627)	0.564	2
UniProt:Q8TBC4 UBA3	2	G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640) UBA3 [cytosol] (R-HSA-947632)	0.556	3

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