Reactome | NAE1 [cytosol]

NAE1 [cytosol]

Stable Identifier

R-HSA-8951449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD8-activating enzyme E1 regulatory subunit, ULA1_HUMAN, APPBP1

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External Reference Information

External Reference

UniProt:Q13564 NAE1

Gene Names

NAE1, APPBP1, HPP1

Chain

initiator methionine:1, chain:2-534

Reference Genes

BioGPS Gene:8883 NAE1

COSMIC (genes):NAE1 NAE1

CTD Gene:8883 NAE1

dbSNP Gene:8883 NAE1

ENSEMBL:ENSG00000159593 NAE1

HGNC:621 NAE1

KEGG Gene (Homo sapiens):8883 NAE1

Monarch:8883 NAE1

NCBI Gene:8883 NAE1

OMIM:603385 NAE1

UCSC:Q13564 NAE1

Reference Transcript

Other Identifiers

11717250_a_at

16827170

202268_PM_s_at

202268_s_at

35364_at

3695269

3695270

3695273

3695276

3695278

3695280

3695282

3695284

3695286

3695287

3695288

3695289

3695290

3695291

3695292

3695293

3695294

3695295

3695296

3695297

3695299

3695300

3695301

3695303

3695306

3695307

8001876

8883

A_23_P77459

GE59214

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006915

GO:0007049

GO:0007165

GO:0008150

GO:0008219

GO:0008641

GO:0016020

GO:0016874

GO:0019781

GO:0019899

GO:0031625

GO:0032446

GO:0032991

GO:0033314

GO:0042981

GO:0043523

GO:0045116

GO:0046982

GO:0051402

HMNXSV003032247

ILMN_1684816

ILMN_1756308

ILMN_2415439

PH_hs_0025090

TC16001174.hg

U50939_at

g4502168_3p_a_at

Participates

as a component of

Inferred To

ptr3 [cytosol] (Schizosaccharomyces pombe)

uba1 [cytosol] (Dictyostelium discoideum)

APP-BP1 [cytosol] (Drosophila melanogaster)

Ghost homologue of NAE1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of NAE1 [cytosol] (Sus scrofa)

nae1 [cytosol] (Danio rerio)

nae1 [cytosol] (Xenopus tropicalis)

NAE1 [cytosol] (Bos taurus)

NAE1 [cytosol] (Canis familiaris)

NAE1 [cytosol] (Gallus gallus)

NAE1 [cytosol] (Plasmodium falciparum)

Nae1 [cytosol] (Mus musculus)

Nae1 [cytosol] (Rattus norvegicus)

UBA1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001018169.1, XP_005256272.1, NP_001018170.1, NP_003896.1, XP_011521724.1, NP_001273429.1

OpenTargets

ENSG00000159593

ZINC - Substances

ULA1_HUMAN

GeneCards

Q13564

HPA

ENSG00000159593-NAE1

Ensembl

ENST00000290810, ENST00000394074, ENSP00000290810, ENST00000359087, ENSP00000368776, ENSP00000351990, ENST00000379463, ENSP00000377637, ENSG00000159593

ZINC - Biogenic

ULA1_HUMAN

ZINC target

Q13564

PRO

Q13564

Pharos - Targets

Q13564

ZINC - Predictions - Purchasable

ULA1_HUMAN

PDB

1YOV, 1R4N, 2NVU, 3DBL, 1R4M, 3DBR, 3DBH, 1TT5, 3GZN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.669	7
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.564	2
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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