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NAE1 [cytosol]
Stable Identifier
R-HSA-8951449
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NEDD8-activating enzyme E1 regulatory subunit, ULA1_HUMAN, APPBP1
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)
AcM-UBE2F:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Homo sapiens)
AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)
AcM-UBE2F:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)
AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NAE1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13564 NAE1
Gene Names
NAE1, APPBP1, HPP1
Chain
initiator methionine:1, chain:2-534
Reference Genes
BioGPS Gene:8883 NAE1
COSMIC (genes):NAE1 NAE1
CTD Gene:8883 NAE1
dbSNP Gene:8883 NAE1
ENSEMBL:ENSG00000159593 NAE1
HGNC:621 NAE1
KEGG Gene (Homo sapiens):8883 NAE1
Monarch:8883 NAE1
NCBI Gene:8883 NAE1
OMIM:603385 NAE1
UCSC:Q13564 NAE1
Reference Transcript
RefSeq:XM_005256215.1 NAE1
RefSeq:NM_001286500.1 NAE1
RefSeq:NM_003905.3 NAE1
RefSeq:NM_001018160.1 NAE1
RefSeq:NM_001018159.1 NAE1
RefSeq:XM_011523422.2 NAE1
Other Identifiers
11717250_a_at
16827170
202268_PM_s_at
202268_s_at
35364_at
3695269
3695270
3695273
3695276
3695278
3695280
3695282
3695284
3695286
3695287
3695288
3695289
3695290
3695291
3695292
3695293
3695294
3695295
3695296
3695297
3695299
3695300
3695301
3695303
3695306
3695307
8001876
8883
A_23_P77459
GE59214
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006915
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008641
GO:0016020
GO:0016874
GO:0019781
GO:0019899
GO:0031625
GO:0032446
GO:0032991
GO:0033314
GO:0042981
GO:0043523
GO:0045116
GO:0046982
GO:0051402
HMNXSV003032247
ILMN_1684816
ILMN_1756308
ILMN_2415439
PH_hs_0025090
TC16001174.hg
U50939_at
g4502168_3p_a_at
Participates
as a component of
UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
Inferred To
ptr3 [cytosol]
(Schizosaccharomyces pombe)
uba1 [cytosol]
(Dictyostelium discoideum)
APP-BP1 [cytosol]
(Drosophila melanogaster)
Ghost homologue of NAE1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of NAE1 [cytosol]
(Sus scrofa)
nae1 [cytosol]
(Danio rerio)
nae1 [cytosol]
(Xenopus tropicalis)
NAE1 [cytosol]
(Bos taurus)
NAE1 [cytosol]
(Canis familiaris)
NAE1 [cytosol]
(Gallus gallus)
NAE1 [cytosol]
(Plasmodium falciparum)
Nae1 [cytosol]
(Mus musculus)
Nae1 [cytosol]
(Rattus norvegicus)
UBA1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001018169.1
,
XP_005256272.1
,
NP_001018170.1
,
NP_003896.1
,
XP_011521724.1
,
NP_001273429.1
OpenTargets
ENSG00000159593
ZINC - Substances
ULA1_HUMAN
GeneCards
Q13564
HPA
ENSG00000159593-NAE1
Ensembl
ENST00000290810
,
ENST00000394074
,
ENSP00000290810
,
ENST00000359087
,
ENSP00000368776
,
ENSP00000351990
,
ENST00000379463
,
ENSP00000377637
,
ENSG00000159593
ZINC - Biogenic
ULA1_HUMAN
ZINC target
Q13564
PRO
Q13564
Pharos - Targets
Q13564
ZINC - Predictions - Purchasable
ULA1_HUMAN
PDB
1YOV
,
1R4N
,
2NVU
,
3DBL
,
1R4M
,
3DBR
,
3DBH
,
1TT5
,
3GZN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.669
7
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.564
2
UniProt:Q8TBC4 UBA3
2
UBA3 [cytosol]
(R-HSA-947632)
G76-NEDD8-C237-UBA3 [cytosol]
(R-HSA-8951640)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
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