Reactome | TGFB1 [plasma membrane]

TGFB1 [plasma membrane]

Stable Identifier

R-HSA-5146781

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TGF-beta-1, Transforming Growth Factor beta 1

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Influenza Infection (Homo sapiens)
    - Host Interactions with Influenza Factors (Homo sapiens)
      - Influenza Virus Induced Apoptosis (Homo sapiens)
        
        NA activation of TGF-beta (Homo sapiens)
        
        Large latent complex of TGFB1 [plasma membrane] (Homo sapiens)
        
        TGFB1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01137 TGFB1

Gene Names

TGFB1, TGFB

Chain

signal peptide:1-29, chain:30-278, chain:279-390

Reference Genes

BioGPS Gene:7040 TGFB1

COSMIC (genes):TGFB1 TGFB1

CTD Gene:7040 TGFB1

dbSNP Gene:7040 TGFB1

ENSEMBL:ENSG00000105329 TGFB1

ENSEMBL_homo_sapiens_GENE:ENSG00000105329 TGFB1

HGNC:11766 TGFB1

KEGG Gene (Homo sapiens):7040 TGFB1

Monarch:7040 TGFB1

NCBI Gene:7040 TGFB1

OMIM:190180 TGFB1

UCSC:P01137 TGFB1

Reference Transcript

RefSeq:NM_000660.6 TGFB1

Other Identifiers

11716385_at

1634_s_at

16872551

1830_s_at

203084_at

203085_s_at

361

3863028

3863029

3863030

3863032

3863033

3863035

3863036

3863037

3863038

3863039

3863040

41445_at

7040

73543

8037005

CCDS33031

ENSG00000105329

ENSP00000221930

ENST00000221930

EntrezGene:7040

g10863872_3p_at

g12652748_3p_a_at

GE59644

GO:0000003

GO:0000060

GO:0000122

GO:0000165

GO:0000278

GO:0001570

GO:0001657

GO:0001666

GO:0001763

GO:0001775

GO:0001837

GO:0001843

GO:0001933

GO:0001934

GO:0002028

GO:0002062

GO:0002244

GO:0002248

GO:0002376

GO:0002460

GO:0002513

GO:0002576

GO:0003013

GO:0003179

GO:0003674

GO:0003823

GO:0005114

GO:0005125

GO:0005160

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005794

GO:0005796

GO:0005886

GO:0005902

GO:0005975

GO:0006259

GO:0006412

GO:0006464

GO:0006468

GO:0006605

GO:0006611

GO:0006629

GO:0006754

GO:0006796

GO:0006810

GO:0006874

GO:0006913

GO:0006950

GO:0006954

GO:0007009

GO:0007010

GO:0007049

GO:0007050

GO:0007093

GO:0007155

GO:0007165

GO:0007173

GO:0007179

GO:0007182

GO:0007183

GO:0007219

GO:0007406

GO:0007435

GO:0007492

GO:0007507

GO:0007565

GO:0007568

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0008354

GO:0009056

GO:0009058

GO:0009314

GO:0009611

GO:0009749

GO:0009790

GO:0009817

GO:0009986

GO:0010033

GO:0010468

GO:0010469

GO:0010575

GO:0010628

GO:0010629

GO:0010716

GO:0010718

GO:0010742

GO:0010763

GO:0010800

GO:0010862

GO:0010936

GO:0014003

GO:0014070

GO:0016192

GO:0016202

GO:0016477

GO:0017015

GO:0019049

GO:0019221

GO:0019899

GO:0021915

GO:0022408

GO:0022607

GO:0030141

GO:0030154

GO:0030198

GO:0030214

GO:0030217

GO:0030234

GO:0030279

GO:0030308

GO:0030316

GO:0030334

GO:0030335

GO:0030424

GO:0030501

GO:0030512

GO:0030879

GO:0031012

GO:0031065

GO:0031093

GO:0031100

GO:0031293

GO:0031334

GO:0031410

GO:0031536

GO:0031663

GO:0032270

GO:0032355

GO:0032570

GO:0032667

GO:0032700

GO:0032740

GO:0032801

GO:0032930

GO:0032943

GO:0032967

GO:0033138

GO:0033280

GO:0034330

GO:0034616

GO:0034641

GO:0034713

GO:0034714

GO:0035066

GO:0035307

GO:0035902

GO:0040007

GO:0040011

GO:0042060

GO:0042110

GO:0042127

GO:0042130

GO:0042306

GO:0042307

GO:0042482

GO:0042493

GO:0042552

GO:0042592

GO:0042802

GO:0042803

GO:0042981

GO:0043011

GO:0043025

GO:0043029

GO:0043065

GO:0043117

GO:0043226

GO:0043406

GO:0043408

GO:0043491

GO:0043536

GO:0043537

GO:0043539

GO:0043552

GO:0043932

GO:0044281

GO:0044403

GO:0045066

GO:0045216

GO:0045589

GO:0045591

GO:0045596

GO:0045599

GO:0045662

GO:0045786

GO:0045892

GO:0045893

GO:0045930

GO:0045944

GO:0046982

GO:0047485

GO:0048146

GO:0048298

GO:0048468

GO:0048535

GO:0048565

GO:0048642

GO:0048646

GO:0048839

GO:0048856

GO:0048870

GO:0050679

GO:0050680

GO:0050714

GO:0050731

GO:0050765

GO:0050777

GO:0050868

GO:0050900

GO:0050921

GO:0051092

GO:0051098

GO:0051101

GO:0051152

GO:0051276

GO:0051280

GO:0051301

GO:0051781

GO:0051897

GO:0055010

GO:0055085

GO:0060312

GO:0060325

GO:0060364

GO:0060389

GO:0060390

GO:0060391

GO:0060395

GO:0060744

GO:0060751

GO:0060762

GO:0060965

GO:0061024

GO:0061035

GO:0062023

GO:0065003

GO:0070168

GO:0070306

GO:0070374

GO:0070723

GO:0071158

GO:0071260

GO:0071363

GO:0071407

GO:0071479

GO:0071549

GO:0071560

GO:0071677

GO:0072562

GO:0085029

GO:0090190

GO:0097191

GO:0097421

GO:0140014

GO:1900126

GO:1900182

GO:1901203

GO:1901666

GO:1902074

GO:1902895

GO:1903077

GO:1903799

GO:1903800

GO:1903911

GO:1905313

GO:1990314

GO:1990402

GO:2000249

GO:2000679

GO:2000727

HGNC:11766

ILMN_1665766

ILMN_2129668

IPR001111

IPR001839

IPR003939

IPR015615

IPR016319

IPR017948

IPR029034

M38449_s_at

MIM:131300

MIM:190180

MIM:219700

NM_000660

NP_000651

PF00019

PF00688

PR01423

PR01424

SM00204

TC19001553.hg

TC19002485.hg

TGFB1

TGFB1-201

uc002oqh.4

UPI000013C7E1

X05839_rna1_s_at

XM_011527242

XP_011525544

Participant Of

hasMember

Proteoglycans,TGFB1 [plasma membrane]

hasComponent

Large latent complex of TGFB1 [plasma membrane]

Other forms of this molecule

TGFB1 [extracellular region]

TGFB1 [Golgi lumen]

TGFB1(30-390) [Golgi lumen]

TGFB1(30-278) [extracellular region]

TGFB1(30-278) [platelet alpha granule lumen]

Inferred To

Homologues of TGFB1 [plasma membrane] (Caenorhabditis elegans)

Homologues of TGFB1 [plasma membrane] (Canis familiaris)

Homologues of TGFB1 [plasma membrane] (Danio rerio)

Homologues of TGFB1 [plasma membrane] (Gallus gallus)

Homologues of TGFB1 [plasma membrane] (Sus scrofa)

TGFB1 [plasma membrane] (Bos taurus)

TGFB1 [plasma membrane] (Caenorhabditis elegans)

TGFB1 [plasma membrane] (Canis familiaris)

TGFB1 [plasma membrane] (Danio rerio)

TGFB1 [plasma membrane] (Drosophila melanogaster)

TGFB1 [plasma membrane] (Gallus gallus)

TGFB1 [plasma membrane] (Mus musculus)

TGFB1 [plasma membrane] (Rattus norvegicus)

TGFB1 [plasma membrane] (Sus scrofa)

TGFB1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000651.3

OpenTargets

ENSG00000105329

GeneCards

P01137

ZINC - Substances

TGFB1_HUMAN

DOCK Blaster

3KFD, 4KV5, 5FFO

ZINC target

P01137

PRO

P01137

BRENDA (Homo sapiens)

2.7.11.30

Orphanet

15606

ZINC - Predictions - Purchasable

TGFB1_HUMAN

PDB

5VQP, 1KLA, 1KLD, 1KLC, 4KV5, 3KFD, 5FFO

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37173 TGFBR2	9	TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.811	6
UniProt:P05067 APP	19	APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.641	3
UniProt:Q14766-1 LTBP1			0.637	4
UniProt:P11464 PSG1	1	PSG1 [extracellular region] (R-HSA-8870766)	0.558	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q12841 FSTL1	3	FSTL1 [endoplasmic reticulum lumen] (R-HSA-8956749) p-FSTL1 [endoplasmic reticulum lumen] (R-HSA-8957089) FSTL1 [extracellular region] (R-HSA-201832)	0.544	2
UniProt:P07996 THBS1	5	THBS1 [platelet alpha granule lumen] (R-HSA-114701) THBS1 [extracellular region] (R-HSA-66518) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263)	0.525	2
UniProt:P01137 TGFB1	6	TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.522	2
UniProt:O60711 LPXN			0.488	2
IntAct:EBI-12416678 RAPGEF3			0.488	2
UniProt:Q5TA81 LCE2C	1	LCE2C [cytosol] (R-HSA-6814284)	0.488	2
UniProt:O14633 LCE2B	1	LCE2B [cytosol] (R-HSA-6814295)	0.488	2
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.488	2
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773) ITGAV(31-1048) [plasma membrane] (R-HSA-210013)	0.488	2
UniProt:Q9BYE3 LCE3D	1	LCE3D [cytosol] (R-HSA-6814297)	0.488	2
UniProt:Q5T751 LCE1C	1	LCE1C [cytosol] (R-HSA-6814267)	0.488	2
UniProt:Q5T752 LCE1D	1	LCE1D [cytosol] (R-HSA-6814283)	0.488	2
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.488	2
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.488	2
UniProt:Q5T7P2 LCE1A	1	LCE1A [cytosol] (R-HSA-6814305)	0.488	2
UniProt:Q5TA76 LCE3A	1	LCE3A [cytosol] (R-HSA-6814296)	0.488	2
UniProt:A0A0C3SFZ9 A0A0C3SFZ9			0.488	2
IntAct:EBI-11749135 KRTAP13			0.488	2
UniProt:Q6UY14-3 ADAMTSL4			0.488	2
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.488	2
UniProt:Q5TA77 LCE3B	1	LCE3B [cytosol] (R-HSA-6814269)	0.488	2
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.488	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.488	2
UniProt:P07237 P4HB	3	HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287) P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902)	0.488	2
UniProt:A8MQ03 CRTP1			0.488	2