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DLG4 [plasma membrane]
Stable Identifier
R-HSA-202135
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PSD-95, SAP-95, Disks large homolog 4
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
LGI-ADAM interactions (Homo sapiens)
LGI1 binds ADAM22 and ADAM23 (Homo sapiens)
ADAM22:LGI1 dimer:ADAM23 [plasma membrane] (Homo sapiens)
ADAM22:PSD-95:stargazin [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
ADAM22:PSD-95:stargazin [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
NrCAM interactions (Homo sapiens)
NrCAM binds synapse-associated proteins (Homo sapiens)
NrCAM:SAP members [plasma membrane] (Homo sapiens)
PSD-95 family [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
PSD-95 family [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Synaptic adhesion-like molecules (Homo sapiens)
PSD-95 binds NMDA receptor (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
NMDAR:PSD-95 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
SALM1 binds NMDA receptor (Homo sapiens)
NMDAR:PSD-95 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
SALM1:NMDAR:PSD-95 [plasma membrane] (Homo sapiens)
NMDAR:PSD-95 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
SALMs 1-3 bind to PSD-95 family members (Homo sapiens)
PSD-95 family [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
SALMs 1-3:PSD-95 family [plasma membrane] (Homo sapiens)
PSD-95 family [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:LRRC7:CaMKII dodecamer [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
Activation of RasGRF (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
NMDA-activated RASGRF1 activates RAS (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Long-term potentiation (Homo sapiens)
CaMKII binds activated NMDA receptor (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
CaMKII phosphorylates AMPA receptor (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Ca2+ influx into the post-synaptic cell (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Activation of kainate receptors upon glutamate binding (Homo sapiens)
Ionotropic activity of kainate receptors (Homo sapiens)
Activation of Ca-permeable Kainate Receptor (Homo sapiens)
Activation of Ca-permeable Kainate receptors (Homo sapiens)
Kainate receptor-glutamate complex [plasma membrane] (Homo sapiens)
Kainate Receptors [plasma membrane] (Homo sapiens)
GRIK 2 homomer [plasma membrane] (Homo sapiens)
GRIK2 interacting proteins [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Homo sapiens)
GRIK4 interacting proteins [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
kainate receptor binds glutamate (Homo sapiens)
Kainate Receptors [plasma membrane] (Homo sapiens)
GRIK 2 homomer [plasma membrane] (Homo sapiens)
GRIK2 interacting proteins [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Homo sapiens)
GRIK4 interacting proteins [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Kainate receptor-glutamate complex [plasma membrane] (Homo sapiens)
Kainate Receptors [plasma membrane] (Homo sapiens)
GRIK 2 homomer [plasma membrane] (Homo sapiens)
GRIK2 interacting proteins [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Homo sapiens)
GRIK4 interacting proteins [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Trafficking of AMPA receptors (Homo sapiens)
Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
TARP-PSD95-Mdm2 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
ERBB4 binds DLG4 (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
ERBB4:DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
CIT-3 binds DLG4 (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Homo sapiens)
DLG4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78352 DLG4
Gene Names
DLG4, PSD95
Chain
chain:1-724
Reference Genes
BioGPS Gene:1742 DLG4
COSMIC (genes):DLG4 DLG4
CTD Gene:1742 DLG4
dbSNP Gene:1742 DLG4
ENSEMBL:ENSG00000132535.22 DLG4
HGNC:2903 DLG4
KEGG Gene (Homo sapiens):1742 DLG4
Monarch:1742 DLG4
NCBI Gene:1742 DLG4
OMIM:602887 DLG4
UCSC:P78352 DLG4
Reference Transcript
RefSeq:NM_001365.4 DLG4
RefSeq:NM_001321075.1 DLG4
RefSeq:NM_001128827.2 DLG4
Other Identifiers
11739815_x_at
11739816_a_at
11741348_x_at
11753305_a_at
16840513
1742
204592_PM_at
204592_at
210684_PM_s_at
210684_s_at
34701_at
3743394
3743395
3743396
3743398
3743401
3743403
3743404
3743406
3743407
3743408
3743409
3743410
3743411
3743414
3743415
3743416
3743417
3743418
3743420
3743424
3743427
3743428
3743429
3743430
3743431
8012054
A_23_P411102
GE59490
GE83836
GO:0002091
GO:0005102
GO:0005109
GO:0005198
GO:0005515
GO:0005737
GO:0005739
GO:0005783
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0007155
GO:0007163
GO:0007165
GO:0007204
GO:0007268
GO:0007399
GO:0007612
GO:0008021
GO:0008022
GO:0008076
GO:0008092
GO:0014069
GO:0016020
GO:0016188
GO:0016192
GO:0019865
GO:0019894
GO:0019900
GO:0019901
GO:0019903
GO:0021987
GO:0023052
GO:0030054
GO:0030154
GO:0030165
GO:0030424
GO:0030425
GO:0030666
GO:0030863
GO:0031234
GO:0031410
GO:0031594
GO:0031697
GO:0031698
GO:0031748
GO:0031812
GO:0032281
GO:0032839
GO:0033130
GO:0034330
GO:0035176
GO:0035254
GO:0035255
GO:0035418
GO:0035641
GO:0035865
GO:0036211
GO:0042995
GO:0043005
GO:0043113
GO:0043197
GO:0043226
GO:0044224
GO:0044300
GO:0044306
GO:0044307
GO:0044309
GO:0044877
GO:0045184
GO:0045197
GO:0045202
GO:0045211
GO:0048168
GO:0048169
GO:0048856
GO:0050775
GO:0050806
GO:0050877
GO:0050885
GO:0055085
GO:0060076
GO:0060997
GO:0061024
GO:0061098
GO:0065003
GO:0071625
GO:0071944
GO:0097060
GO:0097061
GO:0097109
GO:0097110
GO:0097113
GO:0097120
GO:0098609
GO:0098793
GO:0098794
GO:0098839
GO:0098919
GO:0098970
GO:0098978
GO:0099562
GO:0099645
GO:0150012
GO:1904719
GO:1990635
GO:2000310
GO:2000463
GO:2000821
HMNXSV003010658
HMNXSV003033313
HMNXSV003056074
HMNXSV003057455
ILMN_1768595
PH_hs_0002086
TC17001077.hg
U83192_at
g2613005_3p_a_at
g4557528_3p_at
Participates
as a component of
ADAM22:PSD-95:stargazin [plasma membrane] (Homo sapiens)
ERBB4:DLG4 [plasma membrane] (Homo sapiens)
NMDAR:PSD-95 [plasma membrane] (Homo sapiens)
GRIK2 interacting proteins [plasma membrane] (Homo sapiens)
GRIK4 interacting proteins [plasma membrane] (Homo sapiens)
GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
TARP-PSD95-Mdm2 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
as an input of
ERBB4 binds DLG4 (Homo sapiens)
PSD-95 binds NMDA receptor (Homo sapiens)
GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)
CIT-3 binds DLG4 (Homo sapiens)
as a member of
PSD-95 family [plasma membrane] (Homo sapiens)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
Other forms of this molecule
DLG4 [cytosol]
DLG4 [endocytic vesicle membrane]
Inferred To
dlg1 [plasma membrane]
(Drosophila melanogaster)
DLG4 [plasma membrane]
(Bos taurus)
DLG4 [plasma membrane]
(Canis familiaris)
DLG4 [plasma membrane]
(Danio rerio)
DLG4 [plasma membrane]
(Sus scrofa)
Dlg4 [plasma membrane]
(Rattus norvegicus)
SAP-90 [plasma membrane]
(Mus musculus)
dlg-1 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of DLG4 [plasma membrane]
(Gallus gallus)
Ghost homologue of DLG4 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001308004.1
,
NP_001122299.1
,
NP_001356.1
OpenTargets
ENSG00000132535
ZINC - Substances
DLG4_HUMAN
ZINC target
P78352
PRO
P78352
PDB
5J7J
,
3K82
,
6QJN
,
6QJD
,
5JXB
,
6SPV
,
2MES
,
6QJK
,
6QJF
,
6QJJ
,
6QJG
,
6SPZ
,
1KEF
,
6QJI
,
3I4W
,
6QJL
,
3ZRT
GeneCards
P78352
HPA
ENSG00000132535-DLG4
Ensembl
ENSP00000497806
,
ENSP00000307471
,
ENST00000648172
,
ENSP00000382425
,
ENST00000302955
,
ENSG00000132535
,
ENST00000399506
Pharos - Targets
P78352
ZINC - Predictions - Purchasable
DLG4_HUMAN
Orphanet
29627
HMDB Protein
HMDBP01638
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12879 GRIN2A
3
p-Y-GRIN2A [plasma membrane]
(R-HSA-9612190)
GRIN2A [plasma membrane]
(R-HSA-419556)
GRIN2A [endoplasmic reticulum membrane]
(R-HSA-9609760)
0.75
6
UniProt:Q9P021 CRIPT
0.683
5
UniProt:Q13224 GRIN2B
6
p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]
(R-HSA-3928477)
p-Y-GRIN2B [plasma membrane]
(R-HSA-9612185)
GRIN2B [transport vesicle membrane]
(R-HSA-9610568)
GRIN2B [endoplasmic reticulum membrane]
(R-HSA-9609765)
p-Y1474-GRIN2B [plasma membrane]
(R-HSA-9032602)
GRIN2B [plasma membrane]
(R-HSA-419558)
0.683
3
UniProt:P15385
1
Kcna4 [plasma membrane]
(R-RNO-977474)
0.657
9
UniProt:Q15303 ERBB4
0.646
6
UniProt:O14490 DLGAP1
1
DLGAP1 [plasma membrane]
(R-HSA-6794239)
0.592
6
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.592
2
UniProt:O43166 SIPA1L1
1
SPAR [cytosol]
(R-HSA-6794278)
0.592
2
UniProt:P97836-5 DLGAP1
0.567
3
UniProt:P22459 KCNA4
1
KCNA4 [plasma membrane]
(R-HSA-977474)
0.558
2
UniProt:Q09470 KCNA1
1
KCNA1 [plasma membrane]
(R-HSA-977482)
0.558
2
UniProt:Q14957 GRIN2C
3
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.558
4
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.525
3
UniProt:P63142
1
Kcna2 [plasma membrane]
(R-RNO-977477)
0.508
2
UniProt:P10499
1
Kcna1 [plasma membrane]
(R-RNO-977482)
0.508
2
UniProt:P15384
1
Kcna3 [plasma membrane]
(R-RNO-977475)
0.508
2
UniProt:O60333-3 KIF1B
0.508
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.499
2
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