Reactome | DLG4 [endocytic vesicle membrane]

DLG4 [endocytic vesicle membrane]

Stable Identifier

R-HSA-416847

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

PSD95

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Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        TARP-PSD95-Mdm2 [endocytic vesicle membrane] (Homo sapiens)
        
        DLG4 [endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P78352 DLG4

Gene Names

DLG4, PSD95

Chain

chain:1-724

Reference Genes

BioGPS Gene:1742 DLG4

COSMIC (genes):DLG4 DLG4

CTD Gene:1742 DLG4

dbSNP Gene:1742 DLG4

ENSEMBL:ENSG00000132535 DLG4

ENSEMBL_homo_sapiens_GENE:ENSG00000132535.22 DLG4

HGNC:2903 DLG4

KEGG Gene (Homo sapiens):1742 DLG4

Monarch:1742 DLG4

NCBI Gene:1742 DLG4

OMIM:602887 DLG4

UCSC:P78352 DLG4

Reference Transcript

Other Identifiers

11739815_x_at

11739816_a_at

11741348_x_at

11753305_a_at

16840513

1742

204592_PM_at

204592_at

210684_PM_s_at

210684_s_at

34701_at

3743394

3743395

3743396

3743398

3743401

3743403

3743404

3743406

3743407

3743408

3743409

3743410

3743411

3743414

3743415

3743416

3743417

3743418

3743420

3743424

3743427

3743428

3743429

3743430

3743431

8012054

A_23_P411102

GE59490

GE83836

GO:0002091

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0005856

GO:0005886

GO:0005912

GO:0007155

GO:0007163

GO:0007165

GO:0007204

GO:0007268

GO:0007399

GO:0007612

GO:0008021

GO:0008076

GO:0014069

GO:0016020

GO:0016188

GO:0016192

GO:0016323

GO:0019900

GO:0019903

GO:0023052

GO:0030054

GO:0030154

GO:0030165

GO:0030424

GO:0030425

GO:0030666

GO:0030863

GO:0031234

GO:0031410

GO:0031594

GO:0031697

GO:0031748

GO:0031812

GO:0032281

GO:0032839

GO:0033130

GO:0034330

GO:0035176

GO:0035255

GO:0035418

GO:0035641

GO:0035865

GO:0036211

GO:0042995

GO:0043005

GO:0043197

GO:0043226

GO:0044224

GO:0044300

GO:0044306

GO:0044309

GO:0044877

GO:0045184

GO:0045197

GO:0045202

GO:0045211

GO:0048169

GO:0048856

GO:0050806

GO:0050877

GO:0050885

GO:0055085

GO:0060076

GO:0060997

GO:0061024

GO:0061098

GO:0065003

GO:0071625

GO:0071944

GO:0097060

GO:0097109

GO:0097110

GO:0097113

GO:0097120

GO:0098609

GO:0098793

GO:0098794

GO:0098839

GO:0098970

GO:0098978

GO:0099645

GO:0150012

GO:2000310

GO:2000463

GO:2000821

HMNXSV003010658

HMNXSV003033313

HMNXSV003056074

HMNXSV003057455

ILMN_1768595

PH_hs_0002086

TC17001077.hg

U83192_at

g2613005_3p_a_at

g4557528_3p_at

Participates

as a component of

TARP-PSD95-Mdm2 [endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

DLG4 [cytosol]

DLG4 [plasma membrane]

Inferred To

DLG4 [endocytic vesicle membrane] (Bos taurus)

DLG4 [endocytic vesicle membrane] (Canis familiaris)

DLG4 [endocytic vesicle membrane] (Sus scrofa)

Dlg4 [endocytic vesicle membrane] (Mus musculus)

Dlg4 [endocytic vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001356.1, NP_001122299.1, NP_001308004.1

OpenTargets

ENSG00000132535

ZINC - Substances

DLG4_HUMAN

ZINC target

P78352

PRO

P78352

PDB

6QJI, 6SPV, 2MES, 8AH6, 8AH7, 6QJG, 3I4W, 6QJN, 8AH8, 3K82, 6QJF, 5J7J, 6QJL, 5JXB, 1KEF, 3ZRT, 6QJD, 6SPZ, 6QJK, 8AH4, 6QJJ, 8AH5

GeneCards

P78352

HPA

ENSG00000132535-DLG4

Ensembl

ENSP00000307471, ENST00000399506, ENSP00000497806, ENSG00000132535, ENST00000648172, ENST00000302955, ENSP00000382425

Pharos - Targets

P78352

ZINC - Predictions - Purchasable

DLG4_HUMAN

Orphanet

29627

HMDB Protein

HMDBP01638

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13224 GRIN2B	6	p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) GRIN2B [transport vesicle membrane] (R-HSA-9610568) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [plasma membrane] (R-HSA-419558)	0.755	4
UniProt:Q12879 GRIN2A	3	GRIN2A [endoplasmic reticulum membrane] (R-HSA-9609760) p-Y-GRIN2A [plasma membrane] (R-HSA-9612190) GRIN2A [plasma membrane] (R-HSA-419556)	0.75	6
UniProt:Q9P021 CRIPT			0.683	5
UniProt:P15385	1	Kcna4 [plasma membrane] (R-RNO-977474)	0.657	9
UniProt:Q15303 ERBB4			0.646	6
UniProt:O14490 DLGAP1	1	DLGAP1 [plasma membrane] (R-HSA-6794239)	0.592	6
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.592	2
UniProt:O43166 SIPA1L1	1	SPAR [cytosol] (R-HSA-6794278)	0.592	2
UniProt:P97836-5 DLGAP1			0.567	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.558	4
UniProt:P22459 KCNA4	1	KCNA4 [plasma membrane] (R-HSA-977474)	0.558	2
UniProt:Q09470 KCNA1	1	KCNA1 [plasma membrane] (R-HSA-977482)	0.558	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.547	2
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.525	3
UniProt:P63142	1	Kcna2 [plasma membrane] (R-RNO-977477)	0.508	2
UniProt:P10499	1	Kcna1 [plasma membrane] (R-RNO-977482)	0.508	2
UniProt:P15384	1	Kcna3 [plasma membrane] (R-RNO-977475)	0.508	2
UniProt:O60333-3 KIF1B			0.508	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.499	2

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