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APH1B [endosome membrane]
Stable Identifier
R-HSA-9010060
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
APH-1B
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)
gamma-secretase complex [endosome membrane] (Homo sapiens)
APH1 [endosome membrane] (Homo sapiens)
APH1B [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WW43 APH1B
Gene Names
APH1B, PSFL, UNQ688/PRO1328
Chain
chain:1-257
Reference Genes
BioGPS Gene:83464 APH1B
COSMIC (genes):APH1B APH1B
CTD Gene:83464 APH1B
dbSNP Gene:83464 APH1B
ENSEMBL:ENSG00000138613 APH1B
HGNC:24080 APH1B
KEGG:hsa:83464 APH1B
Monarch:83464 APH1B
NCBI Gene:83464 APH1B
OMIM:607630 APH1B
UCSC:Q8WW43 APH1B
Reference Transcript
RefSeq:NM_001145646.1 APH1B
RefSeq:NM_031301.3 APH1B
Other Identifiers
11720067_a_at
11720068_a_at
11740601_a_at
11740602_s_at
11740603_a_at
11756680_a_at
16801862
221036_PM_s_at
221036_s_at
226358_PM_at
226358_at
3010811
3597522
3597523
3597524
3597525
3597526
3597527
3597528
3597530
3597531
3597532
3597533
3597535
3597537
3597539
3597540
3597541
3597542
3597544
3597545
3597547
62125_at
65643_at
7984124
83464
91572_at
A_14_P102504
A_23_P205997
GE534231
GE86938
GO:0000139
GO:0005515
GO:0005783
GO:0005789
GO:0005886
GO:0007219
GO:0007220
GO:0010008
GO:0010950
GO:0016020
GO:0016485
GO:0030133
GO:0030674
GO:0031293
GO:0031410
GO:0034205
GO:0042987
GO:0043085
GO:0043226
GO:0051604
GO:0060090
GO:0061133
GO:0070765
GO:0098772
HMNXSV003003928
Hs.29894.0.A1_3p_at
ILMN_1767816
ILMN_1862217
PH_hs_0003138
PH_hs_0013563
PH_hs_0031187
PH_hs_0034630
TC15000582.hg
g13775223_3p_s_at
Participates
as a member of
APH1 [endosome membrane] (Homo sapiens)
Other forms of this molecule
APH1B [plasma membrane]
Cross References
RefSeq
NP_001139118.1
,
NP_112591.2
ENSEMBL
ENST00000380343
,
ENSP00000261879
,
ENST00000261879
,
ENSP00000369700
OpenTargets
ENSG00000138613
HPA
ENSG00000138613-APH1B
PRO
Q8WW43
Pharos - Targets
Q8WW43
PDB
8OQY
,
8OQZ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
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