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TUBA1B folding intermediate [cytosol]
Stable Identifier
R-HSA-392797
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tubulin K-alpha-1 folding intermediate, alpha K tubulin -1 folding intermediate
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
tubulin-GTP folding intermediate [cytosol] (Homo sapiens)
alpha/beta tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
Post-chaperonin tubulin folding pathway (Homo sapiens)
Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)
Cofactor B:GTP-alpha tubulin [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)
Cofactor B:GTP-alpha tubulin [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1B folding intermediate [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68363 TUBA1B
Gene Names
TUBA1B
Chain
chain:1-451, chain:1-450
Reference Genes
BioGPS Gene:10376 TUBA1B
COSMIC (genes):TUBA1B TUBA1B
CTD Gene:10376 TUBA1B
dbSNP Gene:10376 TUBA1B
ENSEMBL:ENSG00000123416 TUBA1B
HGNC:18809 TUBA1B
KEGG:hsa:10376 TUBA1B
Monarch:10376 TUBA1B
NCBI Gene:10376 TUBA1B
OMIM:602530 TUBA1B
UCSC:P68363 TUBA1B
Reference Transcript
RefSeq:NM_006082.2 TUBA1B
Other Identifiers
10376
11744345_x_at
11756979_x_at
16764285
201090_PM_x_at
201090_x_at
209251_PM_x_at
211058_PM_x_at
211058_x_at
211072_PM_x_at
211072_x_at
211750_PM_x_at
212639_PM_x_at
212639_x_at
213646_PM_x_at
213646_x_at
2872626
32272_at
3344233
3344241
3344242
3413815
3413819
3413821
3413822
3413824
3453738
3453739
3453740
3453741
3453742
3453743
3453744
3453745
3453746
3453747
3453748
3453749
3453750
3453751
3453752
3453753
3453754
3453841
3453845
3453846
3640627
59760_f_at
7963046
GO:0000226
GO:0000278
GO:0003723
GO:0003725
GO:0003824
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005737
GO:0005856
GO:0005874
GO:0005881
GO:0007010
GO:0007017
GO:0015630
GO:0016787
GO:0030705
GO:0031625
GO:0043226
GO:0051301
GO:0071353
HMNXSV003034622
Hs.240615.2.S1_3p_x_at
Hs.272897.2.S1_3p_x_at
ILMN_1742167
ILMN_1800261
PH_hs_0040665
TC12000363.hg
TC12001470.hg
TC12002866.hg
g13623540_3p_x_at
g5174476_3p_x_at
Participates
as a member of
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
Other forms of this molecule
TUBA1B [cytosol]
TUBA1B [axonemal microtubule]
TUBA1B(1-450) [cytosol]
Polyglutamyl-TUBA1B [cytosol]
L-isoglutamyl polyglycyl-TUBA1B [cytosol]
TUBA1B unfolded [cytosol]
Ac K40 TUBA1B [axonemal microtubule]
AcK-TUBA1B [cytosol]
Cross References
RefSeq
NP_006073.2
OpenTargets
ENSG00000123416
ENSEMBL
ENSP00000336799
,
ENST00000336023
HPA
ENSG00000123416-TUBA1B
PRO
P68363
Pharos - Targets
P68363
GlyGen
P68363
HMDB Protein
HMDBP08594
PDB
7LXB
,
7M18
,
6QVE
,
8VRK
,
5IJ0
,
8VRJ
,
6QVJ
,
9BP6
,
5N5N
,
7SJ7
,
6QUS
,
7SJA
,
7SJ9
,
6J8O
,
6I2I
,
7SJ8
,
7Z6S
,
5IJ9
,
6S8L
,
6J4V
,
6QUY
,
7PJF
,
8VA2
,
8VT7
,
6E7B
,
6E7C
,
7ZCW
,
7M20
,
2E4H
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.643
4
UniProt:Q15398 DLGAP5
1
DLGAP5 [cytosol]
(R-HSA-264452)
0.643
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
2
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