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LDLRAP1 [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-8869097
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
low density lipoprotein receptor adapter protein 1, ARH, autosomal recessive hypercholesterolemia protein
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5SW96 LDLRAP1
Gene Names
LDLRAP1, ARH
Chain
chain:1-308
Reference Genes
BioGPS Gene:26119 LDLRAP1
COSMIC (genes):LDLRAP1 LDLRAP1
CTD Gene:26119 LDLRAP1
dbSNP Gene:26119 LDLRAP1
ENSEMBL:ENSG00000157978 LDLRAP1
HGNC:18640 LDLRAP1
KEGG:hsa:26119 LDLRAP1
Monarch:26119 LDLRAP1
NCBI Gene:26119 LDLRAP1
OMIM:605747 LDLRAP1
UCSC:Q5SW96 LDLRAP1
Reference Transcript
RefSeq:NM_015627.2 LDLRAP1
Other Identifiers
11754815_a_at
16660933
16660950
221790_PM_s_at
221790_s_at
2326020
2326021
2326022
2326023
2326024
2326025
2326027
2326028
2326029
2326030
2326031
2326033
2326035
2326037
2326038
2326039
26119
57082_PM_at
57082_at
7899023
A_14_P127708
A_14_P138746
A_21_P0000958
A_21_P0001273
A_23_P158190
A_32_P216548
GE488255
GE88697
GO:0001540
GO:0001784
GO:0005515
GO:0005546
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005883
GO:0005886
GO:0006629
GO:0006897
GO:0006898
GO:0008203
GO:0008289
GO:0009898
GO:0009925
GO:0016192
GO:0030159
GO:0030276
GO:0030301
GO:0030424
GO:0030669
GO:0031410
GO:0031623
GO:0034383
GO:0035591
GO:0035612
GO:0035615
GO:0035650
GO:0042632
GO:0042982
GO:0043226
GO:0043393
GO:0048260
GO:0050750
GO:0055037
GO:0060090
GO:0071345
GO:0090118
GO:0090205
GO:1903076
GO:1904707
GO:1905581
GO:1905602
HMNXSV003019102
HMNXSV003021365
HMNXSV003026706
HMNXSV003037797
HMNXSV003054727
Hs.184482.0.S1_3p_s_at
ILMN_1809040
PH_hs_0010866
TC01000323.hg
TC01000324.hg
TC01004252.hg
p17640
p858
Participates
as a member of
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
LDLRAP1 [plasma membrane]
Inferred To
Ldlrap1 [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Ldlrap1 [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
LDLRAP1 [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
LDLRAP1 [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
LDLRAP1 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
Cross References
RefSeq
NP_056442.2
ENSEMBL
ENST00000374338
,
ENSP00000363458
OpenTargets
ENSG00000157978
HPA
ENSG00000157978-LDLRAP1
PRO
Q5SW96
Pharos - Targets
Q5SW96
Orphanet
LDLRAP1
PDB
2G30
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.887
13
UniProt:Q9UPT6 JIP3
0.718
6
UniProt:Q8NDX1-2 PSD4
0.718
6
UniProt:P63010-2 AP2B1
0.696
5
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
0.681
4
UniProt:P38263 GID4
0.61
4
UniProt:P13378 HXD8
0.556
3
UniProt:Q6ZVH7 ESPNL
1
ESPNL [cytosol]
(R-HSA-9671876)
0.556
3
UniProt:P31273 HOXC8
1
HOXC8 [nucleoplasm]
(R-HSA-3222311)
0.556
8
UniProt:Q10567-3 AP1B1
0.556
3
UniProt:Q02548 PAX5
1
PAX5 [nucleoplasm]
(R-HSA-158583)
0.556
3
UniProt:Q06616 YP174
0.556
3
UniProt:P43358 MAGA4
0.556
3
UniProt:A8MTQ0 NOTO
1
NOTO [nucleoplasm]
(R-HSA-9796216)
0.556
3
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.553
2
UniProt:A6NKD9 CC85C
0.527
2
UniProt:Q9BYT8 NLN
1
NLN [extracellular region]
(R-HSA-8940937)
0.527
2
UniProt:Q6P5S2 LEG1H
0.488
2
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