Reactome | MMP2(67-660) [extracellular region]

MMP2(67-660) [extracellular region]

Stable Identifier

R-HSA-1604345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MMP2 intermediate form, Matrix metalloproteinase-2, MMP2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08253 MMP2

Gene Names

MMP2, CLG4A

Chain

signal peptide:1-29, propeptide:30-109, chain:110-660, chain:445-660

Reference Genes

BioGPS Gene:4313 MMP2

COSMIC (genes):MMP2 MMP2

CTD Gene:4313 MMP2

dbSNP Gene:4313 MMP2

ENSEMBL:ENSG00000087245 MMP2

HGNC:7166 MMP2

KEGG:hsa:4313 MMP2

Monarch:4313 MMP2

NCBI Gene:4313 MMP2

OMIM:120360 MMP2

UCSC:P08253 MMP2

Reference Transcript

Other Identifiers

11741377_a_at

11743250_a_at

11743251_s_at

11745767_a_at

16819062

16819064

201069_PM_at

201069_at

3661685

3661686

3661687

3661688

3661689

3661691

3661692

3661694

3661695

3661696

3661697

3661699

3661701

3661702

3661703

3661704

3661705

3661707

3661708

3661709

3661710

3661711

3661712

3661713

39007_at

4313

56572_at

7995681

A_14_P114963

A_21_P0009102

A_23_P163787

A_33_P3237135

GE79835

GE88806

GO:0001525

GO:0001541

GO:0001542

GO:0001553

GO:0001666

GO:0001955

GO:0001957

GO:0001968

GO:0002376

GO:0003013

GO:0003824

GO:0004175

GO:0004222

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005886

GO:0006508

GO:0006979

GO:0007162

GO:0007507

GO:0007565

GO:0007566

GO:0007567

GO:0008233

GO:0008237

GO:0008270

GO:0009410

GO:0009612

GO:0014012

GO:0014823

GO:0016020

GO:0016477

GO:0016787

GO:0022414

GO:0022617

GO:0030017

GO:0030154

GO:0030163

GO:0030198

GO:0030312

GO:0030335

GO:0030574

GO:0031012

GO:0032526

GO:0034097

GO:0034614

GO:0035094

GO:0035987

GO:0042542

GO:0043065

GO:0043226

GO:0043627

GO:0045906

GO:0046872

GO:0048013

GO:0048246

GO:0048661

GO:0048705

GO:0048771

GO:0048856

GO:0048870

GO:0051602

GO:0055093

GO:0060325

GO:0060346

GO:0060740

GO:0062023

GO:0071230

GO:0071345

GO:0071347

GO:0071392

GO:0071492

GO:0071498

GO:0140096

GO:1903378

GO:1904645

GO:1904707

HMNXSV003033312

HMNXSV003036887

Hs2.367877.1.S1_3p_at

Hs2.367877.1.S1_3p_s_at

ILMN_1762106

M55593_at

PH_hs_0024052

TC16000454.hg

TC16001568.hg

TC16001569.hg

g11342665_3p_at

g11342665_3p_s_at

p20047

Participates

as a component of

MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Homo sapiens)

as an input of

Autocatalytic activation of proMMP2 (Homo sapiens)

as an output of

Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)

Other forms of this molecule

MMP2(110-660) [extracellular region]

MMP2(30-660) [extracellular region]

MMP2(30-66) [extracellular region]

MMP2(67-109) [extracellular region]

Inferred To

Homologues of MMP2(67-660) [extracellular region] (Caenorhabditis elegans)

Homologues of MMP2(67-660) [extracellular region] (Drosophila melanogaster)

MMP2(67-660) [extracellular region] (Bos taurus)

MMP2(67-660) [extracellular region] (Caenorhabditis elegans)

MMP2(67-660) [extracellular region] (Canis familiaris)

MMP2(67-660) [extracellular region] (Danio rerio)

MMP2(67-660) [extracellular region] (Drosophila melanogaster)

MMP2(67-660) [extracellular region] (Gallus gallus)

MMP2(67-660) [extracellular region] (Mus musculus)

MMP2(67-660) [extracellular region] (Rattus norvegicus)

MMP2(67-660) [extracellular region] (Sus scrofa)

MMP2(67-660) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001289439.1, NP_001289437.1, NP_001121363.1, NP_001289438.1, NP_004521.1

ZINC - World Drugs

MMP2_HUMAN

Guide to Pharmacology - Targets

1629

OpenTargets

ENSG00000087245

ENSEMBL

ENST00000219070, ENST00000570308, ENSP00000444143, ENST00000543485, ENST00000437642, ENSP00000394237, ENSP00000219070, ENSP00000461421

ZINC - FDA approved

MMP2_HUMAN

ZINC - Substances

MMP2_HUMAN

ZINC - Biogenic

MMP2_HUMAN

ZINC target

P08253

PRO

P08253

PDB

1RTG, 3AYU, 1CXW, 8H78, 7XJO, 1KS0, 1J7M, 1QIB, 1HOV, 1GEN, 1CK7, 1EAK, 1GXD, 7XGJ

ZINC - Investigational

MMP2_HUMAN

ZINC - Metabolites

MMP2_HUMAN

HPA

ENSG00000087245-MMP2

Pharos - Targets

P08253

Orphanet

MMP2

ZINC - Predictions - Purchasable

MMP2_HUMAN

HMDB Protein

HMDBP02804

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20908 COL5A1	20	3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663)	0.716	4
UniProt:P16035 TIMP2	4	TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944) TIMP2 [tertiary granule lumen] (R-HSA-6800881) TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [extracellular region] (R-HSA-1454879)	0.688	3
UniProt:P05067-PRO_0000000092 APP			0.623	4
UniProt:Q8NBP7 PCSK9	5	PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.618	4
IntAct:EBI-2325312 COLLAGEN			0.618	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q16777 H2AC20	13	HIST2H2AC [nucleoplasm] (R-HSA-181892) AcK-HIST2H2AC [nucleoplasm] (R-HSA-4551338) HIST2H2AC [extracellular region] (R-HSA-977563) MeR12-HIST2H2AC [nucleoplasm] (R-HSA-5229227) Me2aR12-HIST2H2AC [nucleoplasm] (R-HSA-5229306) Me2sR4-HIST2H2AC [nucleoplasm] (R-HSA-5218305) MeR4-HIST2H2AC [nucleoplasm] (R-HSA-5244625) Me2aR4-HIST2H2AC [nucleoplasm] (R-HSA-5244589) MeR30-HIST2H2AC [nucleoplasm] (R-HSA-5244542) Me2aR30-HIST2H2AC [nucleoplasm] (R-HSA-5244562) AcK6-HIST2H2AC [nucleoplasm] (R-HSA-4568572) Ub-HIST2H2AC [nucleoplasm] (R-HSA-6782532) K63polyUb-HIST2H2AC [nucleoplasm] (R-HSA-6783299)	0.527	2
UniProt:P02462 COL4A1	20	GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065761) GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065733) 3x4Hyp-3Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065577) 3x4Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065690) 3x4Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065674) 3x4Hyp-3Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065631) COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065778) 3x4Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065707) 3x4Hyp-3Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065624) 3x4Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065659) 3x4Hyp-3Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065589) 5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065736) 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region] (R-HSA-2682404) 3,4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region] (R-HSA-2682381) 4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region] (R-HSA-2682393) 3x4Hyp-COL4A1(24-?) [extracellular region] (R-HSA-2468122) COL4A1(?-1669) [extracellular region] (R-HSA-2468120) 3x4Hyp-GlcGalHyl-COL4A1(?-1669) [extracellular region] (R-HSA-2468121) COL4A1(24-?) [extracellular region] (R-HSA-2468127) 3x4Hyp-3Hyp-5Hyl-COL4A1(24-?) [extracellular region] (R-HSA-2468124)	0.527	2
UniProt:Q96M94 KLH15			0.527	2
UniProt:Q5KU26 COLEC12	2	COLEC12 [endocytic vesicle membrane] (R-HSA-2981044) COLEC12 [plasma membrane] (R-HSA-2187209)	0.527	2
UniProt:P12109 COL6A1	20	GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023521) 3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023651) GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023608) 3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023576) 3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023560) 3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023660) COL6A1 [endoplasmic reticulum lumen] (R-HSA-1614453) 3x4Hyp-3Hyp-GalHyl-COL6A1 [extracellular region] (R-HSA-2127538) 3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [extracellular region] (R-HSA-2127522) 3x4Hyp-5Hyl-COL6A1 [extracellular region] (R-HSA-2127506) GalHyl-COL6A1 [extracellular region] (R-HSA-2127523) 3x4Hyp-GlcGalHyl-COL6A1 [extracellular region] (R-HSA-2127524) 3x4Hyp-3Hyp-5Hyl-COL6A1 [extracellular region] (R-HSA-2127527) 3x4Hyp-COL6A1 [extracellular region] (R-HSA-2127464) COL6A1 [extracellular region] (R-HSA-2127512) 3x4Hyp-3Hyp-COL6A1 [extracellular region] (R-HSA-2127484) 3x4Hyp-GalHyl-COL6A1 [extracellular region] (R-HSA-2127501) GlcGalHyl-COL6A1 [extracellular region] (R-HSA-2127486) 5Hyl-COL6A1 [extracellular region] (R-HSA-2127519) 3x4Hyp-GlcGalHyl-COL6A1(?-1028) [extracellular region] (R-HSA-2470119)	0.527	2
UniProt:P35625 TIMP3	2	TIMP3 [extracellular region] (R-HSA-1430774) TIMP3 [platelet dense granule lumen] (R-HSA-8848904)	0.527	2
UniProt:P12110 COL6A2	20	3x4Hyp-3Hyp-GalHyl-COL6A2(257-1019) [endoplasmic reticulum lumen] (R-HSA-2023552) 3x4Hyp-GalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023555) GalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2187485) GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2187483) 3x4Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023675) 3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023643) COL6A2 [endoplasmic reticulum lumen] (R-HSA-1614503) COL6A2 [extracellular region] (R-HSA-2127536) 3x4Hyp-GalHyl-COL6A2 [extracellular region] (R-HSA-2127491) 3x4Hyp-5Hyl-COL6A2 [extracellular region] (R-HSA-2127475) 3x4Hyp-COL6A2 [extracellular region] (R-HSA-2127477) GalHyl-COL6A2 [extracellular region] (R-HSA-2127526) 3x4Hyp-3Hyp-COL6A2 [extracellular region] (R-HSA-2127495) 3x4Hyp-3Hyp-GalHyl-COL6A2 [extracellular region] (R-HSA-2127528) 3x4Hyp-3Hyp-5Hyl-COL6A2 [extracellular region] (R-HSA-2127498) 5Hyl-COL6A2 [extracellular region] (R-HSA-2127467) 3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [extracellular region] (R-HSA-2127500) 3x4Hyp-GlcGalHyl-COL6A2 [extracellular region] (R-HSA-2127502) GlcGalHyl-COL6A2 [extracellular region] (R-HSA-2127470) 3x4Hyp-3Hyp-COL6A2(?-1019) [extracellular region] (R-HSA-2470181)	0.527	2
UniProt:P08572 COL4A2	20	3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023633) 3x4Hyp-3Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023568) 3x4Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023589) 3x4Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023657) GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023517) GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023630) COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-1980177) 3x4Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022089) 3x4Hyp-3Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022524) 3x4Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022983) 3x4Hyp-3Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022964) 5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022478) 3,4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region] (R-HSA-2682411) 4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region] (R-HSA-2682409) 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region] (R-HSA-2682392) GalHyl-COL4A2(26-?) [extracellular region] (R-HSA-2468186) 3x4Hyp-3Hyp-GalHyl-COL4A2(26-?) [extracellular region] (R-HSA-2468187) 3x4Hyp-GalHyl-COL4A2(?-1712) [extracellular region] (R-HSA-2468184) 3x4Hyp-3Hyp-5Hyl-COL4A2(26-?) [extracellular region] (R-HSA-2468185) 3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-?) [extracellular region] (R-HSA-2468190)	0.527	2
UniProt:Q14508 WFDC2	1	WFDC2 [extracellular region] (R-HSA-9830363)	0.499	11

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