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S100B [extracellular region]
Stable Identifier
R-HSA-879433
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Protein S100-B, S100B_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Advanced glycosylation endproduct receptor signaling (Homo sapiens)
AGER binds ERK1/2 (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
AGER ligands:AGER:ERK [plasma membrane] (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Homo sapiens)
F-actin capping protein fragment TRTK12:S100B homodimer [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100B homodimer [extracellular region] (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Nuclear signaling by ERBB4 (Homo sapiens)
S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)
S100B [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04271 S100B
Gene Names
S100B
Chain
initiator methionine:, chain:2-92
Reference Genes
BioGPS Gene:6285 S100B
COSMIC (genes):S100B S100B
CTD Gene:6285 S100B
dbSNP Gene:6285 S100B
ENSEMBL:ENSG00000160307 S100B
ENSEMBL_homo_sapiens_GENE:ENSG00000160307.10 S100B
HGNC:10500 S100B
KEGG Gene (Homo sapiens):6285 S100B
Monarch:6285 S100B
NCBI Gene:6285 S100B
OMIM:176990 S100B
UCSC:P04271 S100B
Reference Transcript
RefSeq:NM_006272.2 S100B
RefSeq:XM_017028424.1 S100B
Other Identifiers
11720608_a_at
11754115_a_at
11754116_x_at
16926754
209686_PM_at
209686_at
235_at
3935487
3935488
3935491
3935492
3935494
6285
8071036
A_23_P143526
A_33_P3264514
GE58395
GO:0001726
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0007155
GO:0007409
GO:0007417
GO:0007611
GO:0007613
GO:0008092
GO:0008270
GO:0008284
GO:0023052
GO:0030154
GO:0042802
GO:0042803
GO:0043025
GO:0043123
GO:0043167
GO:0043226
GO:0043231
GO:0044548
GO:0045666
GO:0046872
GO:0048156
GO:0048168
GO:0048306
GO:0048471
GO:0048856
GO:0050786
GO:0050877
GO:0097490
GO:1990138
GO:1990845
HMNXSV003002166
HMNXSV003056562
M59488_at
PH_hs_0025153
TC21000559.hg
g12804680_3p_at
g12804680_3p_x_at
Participates
as an output of
S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)
as a component of
S100B homodimer [extracellular region] (Homo sapiens)
Inferred To
S100B [extracellular region]
(Bos taurus)
S100B [extracellular region]
(Gallus gallus)
S100B [extracellular region]
(Mus musculus)
S100B [extracellular region]
(Rattus norvegicus)
S100B [extracellular region]
(Sus scrofa)
s100b [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_006263.1
,
XP_016883913.1
ZINC - World Drugs
S100B_HUMAN
OpenTargets
ENSG00000160307
ZINC - FDA approved
S100B_HUMAN
ZINC - Substances
S100B_HUMAN
ZINC - Biogenic
S100B_HUMAN
ZINC target
P04271
PRO
P04271
PDB
5CSF
,
3CZT
,
3D0Y
,
5CSN
,
5D7F
,
3HCM
,
2PRU
,
3D10
,
2H61
,
5CSJ
,
1UWO
,
5CSI
,
2M49
,
1MQ1
,
4XYN
HPA
ENSG00000160307-S100B
GeneCards
P04271
Ensembl
ENSG00000160307
,
ENSP00000380769
,
ENSP00000291700
,
ENST00000291700
,
ENST00000397648
Pharos - Targets
P04271
ZINC - Predictions - Purchasable
S100B_HUMAN
HMDB Protein
HMDBP07977
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23297 S100A1
1
S100A1 [extracellular region]
(R-HSA-6805991)
0.966
25
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.961
25
UniProt:P26447 S10A4
0.831
8
UniProt:P29034 S10A2
0.805
9
UniProt:P25815 S100P
2
S100P [extracellular region]
(R-HSA-6804809)
S100P [secretory granule lumen]
(R-HSA-6804782)
0.782
7
UniProt:Q9NZD8 SPG21
0.781
7
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.719
5
UniProt:P06703 S10A6
0.646
6
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.623
3
UniProt:O15151 MDM4
5
PolyUb-MDM4 [nucleoplasm]
(R-HSA-6782502)
p-S403-MDM4 [nucleoplasm]
(R-HSA-349461)
p-S346,S367,S403-MDM4 [nucleoplasm]
(R-HSA-349441)
PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
(R-HSA-6804938)
MDM4 [nucleoplasm]
(R-HSA-349430)
0.611
3
UniProt:P52907 CAPZA1
2
CAPZA1(265-276) [extracellular region]
(R-HSA-879421)
CAPZA1 [cytosol]
(R-HSA-879363)
0.611
3
UniProt:Q13015 AF1Q
0.589
2
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.558
2
UniProt:P41271-2 NBL1
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:Q5T7Y6 Q5T7Y6
0.556
5
UniProt:Q06481-5 APLP2
0.556
3
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
IntAct:EBI-25891165 CCSB
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q86YQ8-2 Q86YQ82
0.556
3
UniProt:P32502
1
GCD7 [cytosol]
(R-SCE-72519)
0.556
3
UniProt:Q8WXG8 S100Z
0.556
3
UniProt:Q13867 BLMH
1
BLMH [cytosol]
(R-HSA-983095)
0.556
3
UniProt:P21860 ERBB3
0.556
3
UniProt:O14576-2 O145762
0.556
3
IntAct:EBI-25891095 CCSB
0.556
3
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.556
3
UniProt:Q07954-2 LRP1
0.556
3
IntAct:EBI-25853226 CCSB
0.556
3
UniProt:P0DMV8 HSPA1A
4
HSPA1A [nucleoplasm]
(R-HSA-6792605)
HSPA1A [extracellular region]
(R-HSA-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-HSA-6801496)
HSPA1A [cytosol]
(R-HSA-6792602)
0.556
3
UniProt:Q9UGL9 CRCT1
0.556
3
UniProt:Q92599-3 SEPTIN8
0.556
3
UniProt:P13051-2 UNG
0.556
3
UniProt:P17028 ZNF24
0.556
3
UniProt:O75553-5 DAB1
0.556
3
UniProt:P27824-2 P278242
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:P06702 S100A9
3
S100A9 [secretory granule lumen]
(R-HSA-6804774)
S100A9 [cytosol]
(R-HSA-9626869)
S100A9 [extracellular region]
(R-HSA-5432857)
0.556
3
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.556
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.556
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.556
3
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.544
2
UniProt:Q15418 RPS6KA1
7
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.544
2
UniProt:P31949 S100A11
2
S100A11 [extracellular region]
(R-HSA-6804808)
S100A11 [secretory granule lumen]
(R-HSA-6804784)
0.543
5
UniProt:Q92843 B2CL2
0.488
2
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