Reactome | IDE [cytosol]

IDE [cytosol]

Stable Identifier

R-HSA-9033133

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Insulin-degrading enzyme ecNumber3.4.24.56/ecNumber, IDE_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14735 IDE

Gene Names

IDE

Chain

chain:1-1019

Reference Genes

BioGPS Gene:3416 IDE

COSMIC (genes):IDE IDE

CTD Gene:3416 IDE

dbSNP Gene:3416 IDE

ENSEMBL:ENSG00000119912 IDE

HGNC:5381 IDE

KEGG:hsa:3416 IDE

Monarch:3416 IDE

NCBI Gene:3416 IDE

OMIM:146680 IDE

UCSC:P14735 IDE

Reference Transcript

Participates

as a member of

Cargo proteins containing PTS1 [cytosol] (Homo sapiens)

Other forms of this molecule

IDE [endosome lumen]

IDE [peroxisomal matrix]

PolyUb-IDE [mitochondrial outer membrane]

IDE [mitochondrial outer membrane]

Inferred To

ide [cytosol] (Xenopus tropicalis)

IDE [cytosol] (Bos taurus)

IDE [cytosol] (Caenorhabditis elegans)

IDE [cytosol] (Canis familiaris)

IDE [cytosol] (Dictyostelium discoideum)

IDE [cytosol] (Drosophila melanogaster)

IDE [cytosol] (Gallus gallus)

IDE [cytosol] (Mus musculus)

IDE [cytosol] (Rattus norvegicus)

IDE [cytosol] (Saccharomyces cerevisiae)

IDE [cytosol] (Schizosaccharomyces pombe)

IDE [cytosol] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2371

OpenTargets

ENSG00000119912

ENSEMBL

ENST00000371581, ENSP00000360637, ENSP00000265986, ENST00000265986, ENSG00000119912

ZINC - Substances

IDE_HUMAN

ZINC target

P14735

PRO

P14735

GlyGen

P14735

PDB

6BFC, 4NXO, 7RZE, 3QZ2, 7RZH, 7RZI, 4GS8, 4M1C, 6BF7, 3N56, 5CJO, 2G49, 4IFH, 6EDS, 2WK3, 6B3Q, 3E4A, 4RAL, 6B7Z, 6B7Y, 4GSC, 7K1E, 3HGZ, 4PFC, 2YPU, 4RE9, 4GSF, 2G56, 6B70, 3N57, 3H44, 4DTT, 4LTE, 7RZF, 3E4Z, 5WOB, 7RZG, 6MQ3, 4DWK, 6BF6, 2WBY, 4QIA, 5UOE, 3E50, 2G48, 2WC0, 2G47, 6BYZ, 4PES, 6BF9, 6BF8, 4PF9, 4PF7, 3CWW, 2JG4, 4IOF, 2G54, 2JBU, 3OFI, 7K1D, 7K1F

HPA

ENSG00000119912-IDE

GeneCards

IDE

Pharos - Targets

P14735

ZINC - Predictions - Purchasable

IDE_HUMAN

HMDB Protein

HMDBP10019

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.527	2
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.527	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.499	2

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