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TTR [azurophil granule lumen]
Stable Identifier
R-HSA-6799366
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule lumen
Synonyms
Transthyretin, TTHY_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
TTR [azurophil granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02766 TTR
Gene Names
TTR, PALB
Chain
signal peptide:1-20, chain:21-147
Reference Genes
BioGPS Gene:7276 TTR
COSMIC (genes):TTR TTR
CTD Gene:7276 TTR
dbSNP Gene:7276 TTR
ENSEMBL:ENSG00000118271 TTR
HGNC:12405 TTR
KEGG:hsa:7276 TTR
Monarch:7276 TTR
NCBI Gene:7276 TTR
OMIM:176300 TTR
UCSC:P02766 TTR
Reference Transcript
RefSeq:NM_000371.3 TTR
Other Identifiers
11754285_a_at
16851786
209660_PM_at
209660_at
32252_at
3783577
3783578
3783579
3783580
3783581
3783582
3783583
3783584
3783587
3783588
3783589
48169_at
56995_at
7276
8020795
A_23_P130333
GE80911
GE85857
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006144
GO:0007165
GO:0035578
GO:0042802
GO:0043226
GO:0048018
GO:0055086
GO:0070062
GO:0070324
GO:0098772
HMNXSV003012754
ILMN_2198912
M15517_cds5_at
PH_hs_0019852
PH_hs_0033292
TC18000129.hg
g5533090_3p_at
Participates
as a member of
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
Other forms of this molecule
TTR [extracellular region]
Inferred To
Homologues of TTR [azurophil granule lumen]
(Caenorhabditis elegans)
Homologues of TTR [azurophil granule lumen]
(Sus scrofa)
TTR [azurophil granule lumen]
(Bos taurus)
TTR [azurophil granule lumen]
(Caenorhabditis elegans)
TTR [azurophil granule lumen]
(Canis familiaris)
TTR [azurophil granule lumen]
(Dictyostelium discoideum)
TTR [azurophil granule lumen]
(Drosophila melanogaster)
TTR [azurophil granule lumen]
(Gallus gallus)
TTR [azurophil granule lumen]
(Mus musculus)
TTR [azurophil granule lumen]
(Rattus norvegicus)
TTR [azurophil granule lumen]
(Schizosaccharomyces pombe)
TTR [azurophil granule lumen]
(Sus scrofa)
TTR [azurophil granule lumen]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2851
OpenTargets
ENSG00000118271
ENSEMBL
ENST00000649620
,
ENST00000237014
,
ENSP00000237014
,
ENSG00000118271
,
ENSP00000497927
ZINC - FDA approved
TTHY_HUMAN
ZINC - Substances
TTHY_HUMAN
ZINC - Biogenic
TTHY_HUMAN
ZINC target
P02766
PRO
P02766
GlyGen
P02766
PDB
3DK0
,
5CM1
,
8C85
,
1DVS
,
3I9I
,
3ESO
,
4ANK
,
5JID
,
6U0Q
,
4PWF
,
6GRP
,
7DT8
,
3NEO
,
3P3T
,
3P3S
,
2NBO
,
5H0Y
,
1TLM
,
1E5A
,
5U4E
,
6TXW
,
4HJU
,
2G3X
,
5IHH
,
1DVT
,
2QGB
,
3ESN
,
3SSG
,
4PWE
,
6R68
,
1FHN
,
6TI9
,
4FI8
,
4WO0
,
3A4F
,
3P3R
,
5U4B
,
8HEJ
,
2NBP
,
5H0Z
,
3FCB
,
4QXV
,
3B56
,
1TT6
,
4HJT
,
4TQP
,
2G3Z
,
5AKV
,
4IKK
,
1DVQ
,
4N85
,
2QEL
,
4MRC
,
1BZ8
,
5FO2
,
3ESP
,
3U2I
,
3DID
,
4WNS
,
4PWH
,
2GAB
,
6E70
,
8II2
,
6E73
,
3CFN
,
4TLK
,
5L4F
,
6EOY
,
4PVL
,
5U48
,
5U4G
,
3GLZ
,
4Y9F
,
3FC8
,
4D7B
,
2H4E
,
3OZK
,
7THA
,
4MRB
,
3GPS
,
6SDZ
,
3BT0
,
8C86
,
8WGT
,
4TNF
,
4PWG
,
1E3F
,
7QC5
,
3P3U
,
6E71
,
1GKO
,
2G4G
,
7YBR
,
5U49
,
3I9A
,
5U4D
,
5DEJ
,
6TXV
,
4Y9E
,
3DGD
,
7EJR
,
4TLS
,
4IKL
,
1DVY
,
6SUH
,
5AKT
,
2QGD
,
7ACU
,
3IPE
,
6R66
,
2G9K
,
4ABV
,
3D7P
,
3NES
,
1Y1D
,
5CR1
,
3CFM
,
4L1T
,
5H0V
,
3TCT
,
1BMZ
,
8W1N
,
1TTA
,
6FXU
,
8VE6
,
4N86
,
8JQW
,
4TQ8
,
5TZL
,
4HIS
,
1DVZ
,
4TNE
,
5DWP
,
3IPB
,
3IMT
,
6XTK
,
4ABU
,
8W47
,
8W48
,
7WL6
,
1THA
,
7OB4
,
6IMX
,
2WQA
,
5NFW
,
4L1S
,
2TRH
,
6FFT
,
6FWD
,
1BZD
,
1TTB
,
5K1N
,
5CLY
,
3I9P
,
3KGU
,
1TTR
,
3DO4
,
1DVU
,
2QGC
,
4FI6
,
8WGS
,
3HJ0
,
3IMV
,
8PKG
,
4FI7
,
7Q9O
,
3NEX
,
3GRB
,
3GS4
,
4PM1
,
5U4C
,
6E6Z
,
3CXF
,
5EZP
,
5L4M
,
8I00
,
5H0W
,
8T5X
,
5CLZ
,
4IKJ
,
8VE4
,
3BSZ
,
1DVX
,
6SUG
,
5AKS
,
1BM7
,
4QRF
,
3IMU
,
2F7I
,
5CN3
,
4ABW
,
5LLL
,
2M5N
,
8JOK
,
3GS0
,
8W45
,
8W46
,
6E78
,
2F8I
,
5U4A
,
5H0X
,
4HJS
,
8W2W
,
1SOK
,
4IKI
,
3W3B
,
5CLX
,
8VE3
,
4N87
,
5OQ0
,
8VE0
,
8W44
,
1QWH
,
4I87
,
7Q3I
,
1ZD6
,
4YDN
,
5FW8
,
1TSH
,
5HJG
,
3DJZ
,
1THC
,
2B9A
,
4Y9B
,
8GBR
,
4IK7
,
2NOY
,
3IMS
,
4TL4
,
8TDN
,
4HIQ
,
3DJT
,
5AL8
,
8VE2
,
8W43
,
6TJN
,
6FZL
,
8PKE
,
7ERI
,
4I85
,
8ADE
,
1ETB
,
4KY2
,
5FW6
,
2B14
,
2PAB
,
7Q9N
,
6E77
,
3CN4
,
5L4I
,
4AC2
,
4IK6
,
4MAS
,
4DET
,
5CNH
,
6D0W
,
3IMR
,
8E7E
,
3M1O
,
3DJS
,
3KGT
,
2QGE
,
8E7I
,
1ICT
,
7W9R
,
4I89
,
6R67
,
8PKF
,
4PMF
,
1Z7J
,
6IMY
,
2FLM
,
5N62
,
5E4O
,
4TKW
,
1FH2
,
4WNJ
,
8PM9
,
1BZE
,
1TTC
,
8VE5
,
7Y1I
,
3KGS
,
4TM9
,
4TQI
,
7W9Q
,
5EN3
,
8W42
,
5AL0
,
5JIQ
,
1E4H
,
6KGB
,
1ZCR
,
4PME
,
7YCQ
,
1ETA
,
3GS7
,
7Q9L
,
4ACT
,
5N5Q
,
6E76
,
4Y9C
,
5BOJ
,
8PM8
,
4AC4
,
1F41
,
4TL5
,
1F86
,
8E7H
,
8TDO
,
4DEW
,
2ROY
,
3U2J
,
8VE1
,
7ERJ
,
5E4A
,
7DT5
,
2G5U
,
4PWI
,
3GRG
,
8E7J
,
7Y6J
,
5AYT
,
1U21
,
6E75
,
8AWI
,
4DER
,
5E23
,
3A4D
,
4PVN
,
3D2T
,
3CN1
,
1RLB
,
5N7C
,
6GR7
,
5LLV
,
6R6I
,
8G9R
,
8WGU
,
4TLT
,
4TNG
,
8HY4
,
2G4E
,
5NFE
,
3CBR
,
8II3
,
6E72
,
7Z60
,
1X7T
,
1TYR
,
3CFQ
,
4PVM
,
5U4F
,
5TTR
,
3CN0
,
1QAB
,
2FBR
,
3OZL
,
4TQH
,
4DEU
,
5K1J
,
5JIM
,
4TLU
,
8JNU
,
4PWK
,
7ERH
,
1TZ8
,
4QYA
,
8I0O
,
7DT3
,
4YDM
,
5FW7
,
2B15
,
8II4
,
3TFB
,
8AWW
,
1III
,
5L4J
,
3IMW
,
4DES
,
4ABQ
,
1IJN
,
3CN3
,
8PMO
,
3NG5
,
3DJR
,
4IIZ
,
2ROX
,
3NEE
,
2TRY
,
7ERK
,
1SOQ
,
7DT6
,
5A6I
,
4PWJ
,
2B77
,
2B16
,
8II1
,
1IIK
,
1X7S
,
6E74
,
3A4E
,
3CFT
,
6EP1
,
4Y9G
,
3CN2
,
1G1O
,
8IG1
,
8E7D
,
3DK2
,
7EJQ
,
8PMA
ZINC - Metabolites
TTHY_HUMAN
HPA
ENSG00000118271-TTR
GeneCards
TTR
Pharos - Targets
P02766
Orphanet
TTR
ZINC - Predictions - Purchasable
TTHY_HUMAN
HMDB Protein
HMDBP01831
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18848 ATF4
2
ATF4 [cytosol]
(R-HSA-381084)
ATF4 [nucleoplasm]
(R-HSA-381016)
0.668
3
UniProt:P02753 RBP4
3
RBP4(19-201) [extracellular region]
(R-HSA-2453675)
RBP4 I41N [extracellular region]
(R-HSA-2471954)
RBP4 G75D [extracellular region]
(R-HSA-2471928)
0.646
4
UniProt:P25713 MT3
1
MT3 [cytosol]
(R-HSA-5660396)
0.593
3
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.558
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:Q8N3R9 MPP5
2
MPP5 [plasma membrane]
(R-HSA-419969)
MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9689606)
0.556
3
UniProt:Q9Y2D1 ATF5
3
ATF5 [mitochondrial matrix]
(R-HSA-9841250)
ATF5 [cytosol]
(R-HSA-9841253)
ATF5 [nucleoplasm]
(R-HSA-9653719)
0.556
3
UniProt:Q13569 TDG
3
TDG [nucleoplasm]
(R-HSA-65812)
monoSUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
polySUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
0.556
3
UniProt:Q8NBJ7 SUMF2
1
SUMF2 [endoplasmic reticulum lumen]
(R-HSA-1614305)
0.556
3
UniProt:Q06136 KDSR
1
KDSR [endoplasmic reticulum membrane]
(R-HSA-428134)
0.556
3
UniProt:Q8N163 CCAR2
2
DBC1 [nucleoplasm]
(R-HSA-3371479)
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
0.556
3
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.553
2
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.553
2
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.553
2
UniProt:P61916 NPC2
3
NPC2 [lysosomal lumen]
(R-HSA-8876488)
NPC2 [extracellular region]
(R-HSA-6806224)
NPC2 [azurophil granule lumen]
(R-HSA-6799163)
0.527
2
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