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monoSUMO1-K35-PIAS4 [nucleoplasm]
Stable Identifier
R-HSA-3968415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PIAS4, E3 SUMO-protein ligase PIAS4 ecNumber6.3.2.-/ecNumber, PIAS4_HUMAN, PIASy, PIASgamma
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of SUMOylation proteins (Homo sapiens)
SUMOylation of PIAS4 with SUMO1 (Homo sapiens)
monoSUMO1-K35-PIAS4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N2W9 PIAS4
Gene Names
PIAS4, PIASG
Chain
initiator methionine:, chain:2-510
Reference Genes
BioGPS Gene:51588 PIAS4
COSMIC (genes):PIAS4 PIAS4
CTD Gene:51588 PIAS4
dbSNP Gene:51588 PIAS4
ENSEMBL:ENSG00000105229 PIAS4
HGNC:17002 PIAS4
KEGG:hsa:51588 PIAS4
Monarch:51588 PIAS4
NCBI Gene:51588 PIAS4
OMIM:605989 PIAS4
UCSC:Q8N2W9 PIAS4
Reference Transcript
RefSeq:NM_015897.3 PIAS4
Other Identifiers
11722233_s_at
11758865_at
16857080
212879_PM_x_at
212879_x_at
212881_PM_at
212881_at
37144_at
3817257
3817258
3817261
3817262
3817265
3817267
3817268
3817269
3817270
3817271
3817273
3817274
3817275
3817277
3817278
3817279
3817280
3817281
3817282
3817283
43516_at
51588
8024740
A_23_P90280
A_24_P48627
A_33_P3211174
A_33_P3260062
GE54707
GO:0000122
GO:0000785
GO:0001942
GO:0003677
GO:0003712
GO:0003714
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006281
GO:0006302
GO:0006355
GO:0006357
GO:0006629
GO:0006766
GO:0007417
GO:0008270
GO:0010804
GO:0016055
GO:0016363
GO:0016605
GO:0016740
GO:0016925
GO:0019789
GO:0031625
GO:0033235
GO:0042359
GO:0043226
GO:0043488
GO:0045892
GO:0046872
GO:0048856
GO:0060090
GO:0060255
GO:0060887
GO:0061665
GO:0120186
GO:0140096
GO:0140110
GO:1902174
GO:1902231
GO:1905168
GO:1990234
HMNXSV003004406
HMNXSV003005600
HMNXSV003009494
Hs.105779.0.A1_3p_at
Hs.105779.0.A1_3p_x_at
Hs.105779.0.A2_3p_at
Hs.105779.0.A2_3p_x_at
ILMN_1802905
PH_hs_0027756
TC19000080.hg
Participates
as an output of
SUMOylation of PIAS4 with SUMO1 (Homo sapiens)
Other forms of this molecule
PIAS4 [nucleoplasm]
Inferred To
Pias4 [nucleoplasm]
(Rattus norvegicus)
PIAS4 [nucleoplasm]
(Bos taurus)
PIAS4 [nucleoplasm]
(Gallus gallus)
PIAS4 [nucleoplasm]
(Sus scrofa)
pias4 [nucleoplasm]
(Xenopus tropicalis)
Homologues of monoSUMO1-K35-PIAS4 [nucleoplasm]
(Saccharomyces cerevisiae)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(Caenorhabditis elegans)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(Danio rerio)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(Mus musculus)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(Saccharomyces cerevisiae)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(Schizosaccharomyces pombe)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 35
Coordinate
35
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_056981.2
OpenTargets
ENSG00000105229
ENSEMBL
ENST00000262971
,
ENSP00000262971
HPA
ENSG00000105229-PIAS4
PRO
Q8N2W9
Pharos - Targets
Q8N2W9
Interactors (56)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.703
6
UniProt:O75528 TADA3
1
TADA3 [nucleoplasm]
(R-HSA-3322966)
0.632
3
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.602
5
UniProt:P11474 ESRRA
1
ESRRA [nucleoplasm]
(R-HSA-446159)
0.573
3
UniProt:Q8IUI8 CRLF3
0.556
3
UniProt:P15976-2 GATA1
0.556
3
IntAct:EBI-25850694 CCSB
0.556
3
UniProt:Q9BSJ5 CQ080
0.556
3
UniProt:Q8TDX7 NEK7
2
NEK7 [cytosol]
(R-HSA-2530599)
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q8WZ19 KCTD13
1
KCTD13 [cytosol]
(R-HSA-9696533)
0.556
3
UniProt:O60551 NMT2
1
NMT2 [cytosol]
(R-HSA-184377)
0.556
3
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.556
3
UniProt:Q15078 CDK5R1
4
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.556
3
UniProt:Q14693 LPIN1
3
LPIN1 [endoplasmic reticulum membrane]
(R-HSA-549157)
LPIN1 [nuclear envelope]
(R-HSA-4419927)
p-S106-LPIN1 [nucleoplasm]
(R-HSA-4419936)
0.556
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:Q96IK1-2 Q96IK12
0.556
3
UniProt:Q9Y4H4 GPSM3
1
GPSM3 [cytosol]
(R-HSA-8949486)
0.556
3
UniProt:Q8NCN2 ZBT34
0.556
3
UniProt:O75446 SAP30
1
SAP30 [nucleoplasm]
(R-HSA-351693)
0.556
3
UniProt:Q8N5S9-2 Q8N5S92
0.556
3
UniProt:Q96GM5 SMARCD1
1
SMARCD1 [nucleoplasm]
(R-HSA-389255)
0.556
3
UniProt:I6L9F6 I6L9F6
0.556
3
UniProt:O95789-4 ZMYM6
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q5T752 LCE1D
1
LCE1D [cytosol]
(R-HSA-6814283)
0.556
3
UniProt:F2Z2M7 F2Z2M7
0.556
3
IntAct:EBI-25849442 CCSB
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
UniProt:P80217-2 IFI35
0.556
3
UniProt:Q6ZP82-1 CCDC141
0.556
3
UniProt:Q8TD91-2 MAGEC3
0.556
3
UniProt:O00635 TRIM38
1
TRIM38 [cytosol]
(R-HSA-5624325)
0.556
3
UniProt:Q8TAK5 GABP2
0.556
3
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
DLST [mitochondrial matrix]
(R-HSA-6792574)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
0.556
3
UniProt:O00472 ELL2
1
ELL2 [nucleoplasm]
(R-HSA-6807506)
0.556
3
UniProt:P57052 RBM11
0.556
3
UniProt:Q86W54-2 SPATA24
0.556
3
UniProt:Q6P1L5 F117B
0.556
3
UniProt:Q92615 LAR4B
0.556
3
UniProt:O43865 AHCYL1
1
AHCYL1 [endoplasmic reticulum membrane]
(R-HSA-5215973)
0.556
3
UniProt:Q9NP98 MYOZ1
0.556
3
UniProt:Q9NX94 WBP1L
0.556
3
UniProt:Q9UKP3-2 Q9UKP32
0.556
3
UniProt:O60902-3 SHOX2
0.556
3
UniProt:P12830 CDH1
8
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
0.556
3
UniProt:P02340 Tp53
20
TP53 [cytosol]
(R-MMU-8869337)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-MMU-2997661)
p- S18-Tp53 [nucleoplasm]
(R-MMU-9816424)
phospho-p-S15,S20-TP53 [nucleoplasm]
(R-MMU-69683)
phospho-p-S15-TP53 [nucleoplasm]
(R-MMU-69507)
TP53 [nucleoplasm]
(R-MMU-69488)
PolyUb-TP53 [cytosol]
(R-MMU-6793681)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6793679)
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6804446)
phospho-p-S37-TP53 [nucleoplasm]
(R-MMU-3239022)
phospho-p-T55-TP53 [nucleoplasm]
(R-MMU-6805400)
phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-MMU-6805133)
phospho-p-S15,S20,S46-TP53 [nucleoplasm]
(R-MMU-6798369)
phospho-p-S15,S392-TP53 [nucleoplasm]
(R-MMU-3222015)
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
(R-MMU-6805268)
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
(R-MMU-6805053)
phospho-p-S315-TP53 [nucleoplasm]
(R-MMU-6805106)
phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-5628868)
phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6805631)
0.553
2
UniProt:Q9NS85 CAH10
0.527
2
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.524
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.508
2
UniProt:P61956 SUMO2
6
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
(R-HSA-9761546)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
lysyl-G93-SUMO2 [cytosol]
(R-HSA-9834803)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
0.508
3
UniProt:Q02880 TOP2B
2
monoSUMO1-K-TOP2B [nucleoplasm]
(R-HSA-4641297)
TOP2B [nucleoplasm]
(R-HSA-4641359)
0.499
2
UniProt:P36780 VE2
0.488
2
UniProt:P03118 VE2
0.488
2
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