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PINK1 [mitochondrial outer membrane]
Stable Identifier
R-HSA-5205653
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Serine/threonine-protein kinase PINK1, mitochondrial ecNumber2.7.11.1/ecNumber, PINK1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
PARK2:PINK1 [mitochondrial outer membrane] (Homo sapiens)
PINK1 [mitochondrial outer membrane] (Homo sapiens)
Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)
PARK2:PINK1 [mitochondrial outer membrane] (Homo sapiens)
PINK1 [mitochondrial outer membrane] (Homo sapiens)
PINK1 [mitochondrial outer membrane] (Homo sapiens)
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
PINK1 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXM7 PINK1
Gene Names
PINK1
Chain
transit peptide:1-77, chain:78-581
Reference Genes
BioGPS Gene:65018 PINK1
COSMIC (genes):PINK1 PINK1
CTD Gene:65018 PINK1
dbSNP Gene:65018 PINK1
ENSEMBL:ENSG00000158828.8 PINK1
HGNC:14581 PINK1
KEGG Gene (Homo sapiens):65018 PINK1
Monarch:65018 PINK1
NCBI Gene:65018 PINK1
OMIM:608309 PINK1
UCSC:Q9BXM7 PINK1
Reference Transcript
RefSeq:NM_032409.2 PINK1
Other Identifiers
11726995_at
11726996_at
16660367
209018_PM_s_at
209018_s_at
209019_PM_s_at
209019_s_at
2324098
2324099
2324100
2324101
2324104
2324106
2324110
2324112
2324114
2324115
2324116
2324117
2324118
2324119
2324120
2324121
2324126
35361_at
65018
7898663
GE62219
GO:0000166
GO:0000287
GO:0000422
GO:0000423
GO:0000785
GO:0001934
GO:0002020
GO:0002082
GO:0002376
GO:0002931
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005758
GO:0005783
GO:0005829
GO:0005856
GO:0006091
GO:0006351
GO:0006355
GO:0006468
GO:0006511
GO:0006886
GO:0006914
GO:0006979
GO:0007005
GO:0010310
GO:0010629
GO:0010821
GO:0010857
GO:0010952
GO:0012501
GO:0014046
GO:0016020
GO:0016192
GO:0016239
GO:0016242
GO:0016301
GO:0016310
GO:0016504
GO:0016567
GO:0016740
GO:0018105
GO:0022904
GO:0023052
GO:0030097
GO:0030163
GO:0030424
GO:0030426
GO:0031396
GO:0031398
GO:0031625
GO:0032148
GO:0032226
GO:0033138
GO:0033603
GO:0033605
GO:0034599
GO:0035307
GO:0035556
GO:0036211
GO:0036289
GO:0038203
GO:0042981
GO:0043066
GO:0043123
GO:0043226
GO:0043254
GO:0043422
GO:0043523
GO:0043524
GO:0044297
GO:0044877
GO:0045727
GO:0046329
GO:0046872
GO:0048471
GO:0048856
GO:0050432
GO:0050821
GO:0050896
GO:0051091
GO:0051171
GO:0051443
GO:0051649
GO:0051881
GO:0051897
GO:0055085
GO:0055086
GO:0055131
GO:0060255
GO:0061024
GO:0061136
GO:0065003
GO:0071456
GO:0072655
GO:0072656
GO:0080090
GO:0090141
GO:0090200
GO:0090258
GO:0097237
GO:0097413
GO:0097449
GO:0098772
GO:0098779
GO:0099074
GO:0106310
GO:0140096
GO:1900407
GO:1901135
GO:1901215
GO:1901525
GO:1901727
GO:1902803
GO:1902902
GO:1902958
GO:1903146
GO:1903202
GO:1903204
GO:1903214
GO:1903298
GO:1903384
GO:1903751
GO:1903852
GO:1903955
GO:1904544
GO:1904783
GO:1904841
GO:1904881
GO:1904925
GO:2000377
GO:2000378
GO:2001171
GO:2001243
HMNXSV003041263
Hs.6163.0.A1_3p_a_at
ILMN_1666924
PH_hs_0025759
TC01000262.hg
g13492051_3p_a_at
Participates
as an output of
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
as an input of
Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)
as a component of
PARK2:PINK1 [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
PINK1 [mitochondrial intermembrane space]
PINK1 [cytosol]
PINK1(111-581) [mitochondrial intermembrane space]
Inferred To
PINK1 [mitochondrial outer membrane]
(Bos taurus)
PINK1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
PINK1 [mitochondrial outer membrane]
(Canis familiaris)
PINK1 [mitochondrial outer membrane]
(Danio rerio)
PINK1 [mitochondrial outer membrane]
(Drosophila melanogaster)
PINK1 [mitochondrial outer membrane]
(Mus musculus)
PINK1 [mitochondrial outer membrane]
(Rattus norvegicus)
PINK1 [mitochondrial outer membrane]
(Sus scrofa)
Cross References
RefSeq
NP_115785.1
Guide to Pharmacology - Targets
2161
OpenTargets
ENSG00000158828
HPA
ENSG00000158828-PINK1
GeneCards
Q9BXM7
Ensembl
ENSP00000364204
,
ENST00000321556
,
ENSG00000158828
PRO
Q9BXM7
Pharos - Targets
Q9BXM7
Orphanet
15094
HMDB Protein
HMDBP01217
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PRKN
3
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
PRKN [cytosol]
(R-HSA-201579)
0.748
7
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.576
8
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.57
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:Q9UBQ0-2 VPS29
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:Q8N895 ZN366
0.556
3
UniProt:P63010-2 AP2B1
0.556
3
IntAct:EBI-25842456 CCSB
0.556
3
UniProt:P28347-2 TEAD1
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.556
3
UniProt:P00491 PNP
7
PNP R234P [cytosol]
(R-HSA-9735772)
PNP E89K [cytosol]
(R-HSA-9735781)
PNP D128G [cytosol]
(R-HSA-9735785)
PNP [cytosol]
(R-HSA-61933)
PNP [secretory granule lumen]
(R-HSA-6803318)
PNP [extracellular region]
(R-HSA-6806505)
PNP [ficolin-1-rich granule lumen]
(R-HSA-6803278)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9UHY8 FEZ2
0.556
3
UniProt:Q6DN90-2 Q6DN902
0.556
3
UniProt:Q8IXI2 RHOT1
2
RHOT1 [mitochondrial outer membrane]
(R-HSA-3006728)
PolyUb-RHOT1 [mitochondrial outer membrane]
(R-HSA-6783139)
0.524
3
UniProt:Q96JZ2 HSH2D
0.488
2
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