Reactome | PINK1 [mitochondrial outer membrane]

PINK1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-5205653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Serine/threonine-protein kinase PINK1, mitochondrial ecNumber2.7.11.1/ecNumber, PINK1_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BXM7 PINK1

Gene Names

PINK1

Chain

transit peptide:1-77, chain:78-581

Reference Genes

BioGPS Gene:65018 PINK1

COSMIC (genes):PINK1 PINK1

CTD Gene:65018 PINK1

dbSNP Gene:65018 PINK1

ENSEMBL:ENSG00000158828.8 PINK1

HGNC:14581 PINK1

KEGG Gene (Homo sapiens):65018 PINK1

Monarch:65018 PINK1

NCBI Gene:65018 PINK1

OMIM:608309 PINK1

UCSC:Q9BXM7 PINK1

Reference Transcript

RefSeq:NM_032409.2 PINK1

Other Identifiers

11726995_at

11726996_at

16660367

209018_PM_s_at

209018_s_at

209019_PM_s_at

209019_s_at

2324098

2324099

2324100

2324101

2324104

2324106

2324110

2324112

2324114

2324115

2324116

2324117

2324118

2324119

2324120

2324121

2324126

35361_at

65018

7898663

GE62219

GO:0000166

GO:0000287

GO:0000422

GO:0000423

GO:0000785

GO:0001934

GO:0002020

GO:0002082

GO:0002376

GO:0002931

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005758

GO:0005783

GO:0005829

GO:0005856

GO:0006091

GO:0006351

GO:0006355

GO:0006468

GO:0006511

GO:0006886

GO:0006914

GO:0006979

GO:0007005

GO:0010310

GO:0010629

GO:0010821

GO:0010857

GO:0010952

GO:0012501

GO:0014046

GO:0016020

GO:0016192

GO:0016239

GO:0016242

GO:0016301

GO:0016310

GO:0016504

GO:0016567

GO:0016740

GO:0018105

GO:0022904

GO:0023052

GO:0030097

GO:0030163

GO:0030424

GO:0030426

GO:0031396

GO:0031398

GO:0031625

GO:0032148

GO:0032226

GO:0033138

GO:0033603

GO:0033605

GO:0034599

GO:0035307

GO:0035556

GO:0036211

GO:0036289

GO:0038203

GO:0042981

GO:0043066

GO:0043123

GO:0043226

GO:0043254

GO:0043422

GO:0043523

GO:0043524

GO:0044297

GO:0044877

GO:0045727

GO:0046329

GO:0046872

GO:0048471

GO:0048856

GO:0050432

GO:0050821

GO:0050896

GO:0051091

GO:0051171

GO:0051443

GO:0051649

GO:0051881

GO:0051897

GO:0055085

GO:0055086

GO:0055131

GO:0060255

GO:0061024

GO:0061136

GO:0065003

GO:0071456

GO:0072655

GO:0072656

GO:0080090

GO:0090141

GO:0090200

GO:0090258

GO:0097237

GO:0097413

GO:0097449

GO:0098772

GO:0098779

GO:0099074

GO:0106310

GO:0140096

GO:1900407

GO:1901135

GO:1901215

GO:1901525

GO:1901727

GO:1902803

GO:1902902

GO:1902958

GO:1903146

GO:1903202

GO:1903204

GO:1903214

GO:1903298

GO:1903384

GO:1903751

GO:1903852

GO:1903955

GO:1904544

GO:1904783

GO:1904841

GO:1904881

GO:1904925

GO:2000377

GO:2000378

GO:2001171

GO:2001243

HMNXSV003041263

Hs.6163.0.A1_3p_a_at

ILMN_1666924

PH_hs_0025759

TC01000262.hg

g13492051_3p_a_at

Participates

as an output of

Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)

as an input of

Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)

as a component of

PARK2:PINK1 [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

PINK1 [mitochondrial intermembrane space]

PINK1 [cytosol]

PINK1(111-581) [mitochondrial intermembrane space]

Inferred To

PINK1 [mitochondrial outer membrane] (Bos taurus)

PINK1 [mitochondrial outer membrane] (Caenorhabditis elegans)

PINK1 [mitochondrial outer membrane] (Canis familiaris)

PINK1 [mitochondrial outer membrane] (Danio rerio)

PINK1 [mitochondrial outer membrane] (Drosophila melanogaster)

PINK1 [mitochondrial outer membrane] (Mus musculus)

PINK1 [mitochondrial outer membrane] (Rattus norvegicus)

PINK1 [mitochondrial outer membrane] (Sus scrofa)

Cross References

RefSeq

NP_115785.1

Guide to Pharmacology - Targets

2161

OpenTargets

ENSG00000158828

HPA

ENSG00000158828-PINK1

GeneCards

Q9BXM7

Ensembl

ENSP00000364204, ENST00000321556, ENSG00000158828

PRO

Q9BXM7

Pharos - Targets

Q9BXM7

Orphanet

15094

HMDB Protein

HMDBP01217

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60260 PRKN	3	polyUb-PARK2 [cytosol] (R-HSA-5689094) p-S9-PRKN [cytosol] (R-HSA-9793481) PRKN [cytosol] (R-HSA-201579)	0.748	7
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.576	8
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.57	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q9UBQ0-2 VPS29			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:Q8N895 ZN366			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
IntAct:EBI-25842456 CCSB			0.556	3
UniProt:P28347-2 TEAD1			0.556	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.556	3
UniProt:P00491 PNP	7	PNP R234P [cytosol] (R-HSA-9735772) PNP E89K [cytosol] (R-HSA-9735781) PNP D128G [cytosol] (R-HSA-9735785) PNP [cytosol] (R-HSA-61933) PNP [secretory granule lumen] (R-HSA-6803318) PNP [extracellular region] (R-HSA-6806505) PNP [ficolin-1-rich granule lumen] (R-HSA-6803278)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9UHY8 FEZ2			0.556	3
UniProt:Q6DN90-2 Q6DN902			0.556	3
UniProt:Q8IXI2 RHOT1	2	RHOT1 [mitochondrial outer membrane] (R-HSA-3006728) PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139)	0.524	3
UniProt:Q96JZ2 HSH2D			0.488	2

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