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PINK1 [mitochondrial outer membrane]
Stable Identifier
R-HSA-5205653
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Serine/threonine-protein kinase PINK1, mitochondrial ecNumber2.7.11.1/ecNumber, PINK1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
PINK1 is autophosphorylated (Homo sapiens)
PINK1 [mitochondrial outer membrane] (Homo sapiens)
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
PINK1 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXM7 PINK1
Gene Names
PINK1
Chain
transit peptide:1-77, chain:78-581
Reference Genes
BioGPS Gene:65018 PINK1
COSMIC (genes):PINK1 PINK1
CTD Gene:65018 PINK1
dbSNP Gene:65018 PINK1
ENSEMBL:ENSG00000158828 PINK1
HGNC:14581 PINK1
KEGG:hsa:65018 PINK1
Monarch:65018 PINK1
NCBI Gene:65018 PINK1
OMIM:608309 PINK1
UCSC:Q9BXM7 PINK1
Reference Transcript
RefSeq:NM_032409.2 PINK1
Participates
as an output of
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
as an input of
PINK1 is autophosphorylated (Homo sapiens)
Other forms of this molecule
p-S228,S402-PINK1 [mitochondrial outer membrane]
PINK1 [mitochondrial intermembrane space]
PINK1 [cytosol]
PINK1(111-581) [mitochondrial intermembrane space]
Inferred To
pink1 [mitochondrial outer membrane]
(Danio rerio)
PINK1 [mitochondrial outer membrane]
(Bos taurus)
PINK1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
PINK1 [mitochondrial outer membrane]
(Canis familiaris)
PINK1 [mitochondrial outer membrane]
(Drosophila melanogaster)
PINK1 [mitochondrial outer membrane]
(Mus musculus)
PINK1 [mitochondrial outer membrane]
(Rattus norvegicus)
PINK1 [mitochondrial outer membrane]
(Sus scrofa)
Cross References
RefSeq
NP_115785.1
Guide to Pharmacology - Targets
2161
OpenTargets
ENSG00000158828
ENSEMBL
ENSP00000364204
,
ENSG00000158828
,
ENST00000321556
IntEnz
2.7.11.1
HPA
ENSG00000158828-PINK1
GeneCards
PINK1
PRO
Q9BXM7
Pharos - Targets
Q9BXM7
Orphanet
PINK1
HMDB Protein
HMDBP01217
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PARK2
4
PRKN [cytosol]
(R-HSA-201579)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
0.748
7
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.576
8
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.57
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.564
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P28347-2 TEAD1
0.556
3
UniProt:P00491 PNP
7
PNP [ficolin-1-rich granule lumen]
(R-HSA-6803278)
PNP [extracellular region]
(R-HSA-6806505)
PNP [secretory granule lumen]
(R-HSA-6803318)
PNP [cytosol]
(R-HSA-61933)
PNP D128G [cytosol]
(R-HSA-9735785)
PNP E89K [cytosol]
(R-HSA-9735781)
PNP R234P [cytosol]
(R-HSA-9735772)
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:Q6DN90-2 Q6DN902
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:Q8N895 ZN366
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:P63010-2 AP2B1
0.556
3
IntAct:EBI-25842456 CCSB
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.556
3
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.556
3
UniProt:Q9UHY8 FEZ2
0.556
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.547
2
UniProt:P48594 SPB4
0.527
2
UniProt:O75153 CLU
0.527
3
UniProt:Q8IXI2 RHOT1
2
PolyUb-RHOT1 [mitochondrial outer membrane]
(R-HSA-6783139)
RHOT1 [mitochondrial outer membrane]
(R-HSA-3006728)
0.524
3
UniProt:Q96JZ2 HSH2D
0.488
2
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