Reactome | PINK1 [mitochondrial outer membrane]

PINK1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-5205653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Serine/threonine-protein kinase PINK1, mitochondrial ecNumber2.7.11.1/ecNumber, PINK1_HUMAN

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External Reference Information

External Reference

UniProt:Q9BXM7 PINK1

Gene Names

PINK1

Chain

transit peptide:1-77, chain:78-581

Reference Genes

BioGPS Gene:65018 PINK1

COSMIC (genes):PINK1 PINK1

CTD Gene:65018 PINK1

dbSNP Gene:65018 PINK1

ENSEMBL:ENSG00000158828 PINK1

HGNC:14581 PINK1

KEGG:hsa:65018 PINK1

Monarch:65018 PINK1

NCBI Gene:65018 PINK1

OMIM:608309 PINK1

UCSC:Q9BXM7 PINK1

Reference Transcript

RefSeq:NM_032409.2 PINK1

Participates

as an output of

Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)

as an input of

PINK1 is autophosphorylated (Homo sapiens)

Other forms of this molecule

p-S228,S402-PINK1 [mitochondrial outer membrane]

PINK1 [mitochondrial intermembrane space]

PINK1 [cytosol]

PINK1(111-581) [mitochondrial intermembrane space]

Inferred To

pink1 [mitochondrial outer membrane] (Danio rerio)

PINK1 [mitochondrial outer membrane] (Bos taurus)

PINK1 [mitochondrial outer membrane] (Caenorhabditis elegans)

PINK1 [mitochondrial outer membrane] (Canis familiaris)

PINK1 [mitochondrial outer membrane] (Drosophila melanogaster)

PINK1 [mitochondrial outer membrane] (Mus musculus)

PINK1 [mitochondrial outer membrane] (Rattus norvegicus)

PINK1 [mitochondrial outer membrane] (Sus scrofa)

Cross References

RefSeq

NP_115785.1

Guide to Pharmacology - Targets

2161

OpenTargets

ENSG00000158828

ENSEMBL

ENSP00000364204, ENSG00000158828, ENST00000321556

IntEnz

2.7.11.1

HPA

ENSG00000158828-PINK1

GeneCards

PINK1

PRO

Q9BXM7

Pharos - Targets

Q9BXM7

Orphanet

PINK1

HMDB Protein

HMDBP01217

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60260 PARK2	4	PRKN [cytosol] (R-HSA-201579) p-S65-PRKN [cytosol] (R-HSA-9834954) p-S9-PRKN [cytosol] (R-HSA-9793481) polyUb-PARK2 [cytosol] (R-HSA-5689094)	0.748	7
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.576	8
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.57	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P28347-2 TEAD1			0.556	3
UniProt:P00491 PNP	7	PNP [ficolin-1-rich granule lumen] (R-HSA-6803278) PNP [extracellular region] (R-HSA-6806505) PNP [secretory granule lumen] (R-HSA-6803318) PNP [cytosol] (R-HSA-61933) PNP D128G [cytosol] (R-HSA-9735785) PNP E89K [cytosol] (R-HSA-9735781) PNP R234P [cytosol] (R-HSA-9735772)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:Q6DN90-2 Q6DN902			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q8N895 ZN366			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
IntAct:EBI-25842456 CCSB			0.556	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.556	3
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.556	3
UniProt:Q9UHY8 FEZ2			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.547	2
UniProt:P48594 SPB4			0.527	2
UniProt:O75153 CLU			0.527	3
UniProt:Q8IXI2 RHOT1	2	PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139) RHOT1 [mitochondrial outer membrane] (R-HSA-3006728)	0.524	3
UniProt:Q96JZ2 HSH2D			0.488	2