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PPP3CC [cytosol]
Stable Identifier
R-HSA-61113
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Calcineurin B gamma, catalytic, Serine/threonine protein phosphatase 2B catalytic subunit, gamma isoform , Calmodulin-dependent calcineurin A subunit, gamma isoform, Calcineurin, testis-specific catalytic subunit, CAM-PRP catalytic subunit
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BAD and translocation to mitochondria (Homo sapiens)
Activation of BAD by calcineurin (Homo sapiens)
Calcineurin B complex [cytosol] (Homo sapiens)
PPP3CC [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)
PP2B catalytic (Fe3+, Zn2+) [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CC [cytosol] (Homo sapiens)
PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaM [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CC [cytosol] (Homo sapiens)
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
PP2B catalytic (Fe3+, Zn2+) [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CC [cytosol] (Homo sapiens)
PPP3 complex [cytosol] (Homo sapiens)
PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaM [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48454 PPP3CC
Gene Names
PPP3CC, CALNA3, CNA3
Chain
chain:1-512
Reference Genes
BioGPS Gene:5533 PPP3CC
COSMIC (genes):PPP3CC PPP3CC
CTD Gene:5533 PPP3CC
dbSNP Gene:5533 PPP3CC
ENSEMBL:ENSG00000120910 PPP3CC
ENSEMBL_homo_sapiens_GENE:ENSG00000120910.15 PPP3CC
HGNC:9316 PPP3CC
KEGG Gene (Homo sapiens):5533 PPP3CC
Monarch:5533 PPP3CC
NCBI Gene:5533 PPP3CC
OMIM:114107 PPP3CC
UCSC:P48454 PPP3CC
Reference Transcript
RefSeq:NM_005605.4 PPP3CC
RefSeq:NM_001243975.1 PPP3CC
RefSeq:NM_001243974.1 PPP3CC
Other Identifiers
11722420_a_at
17066627
207000_PM_s_at
207000_s_at
3089402
3089403
3089404
3089408
3089409
3089427
3089428
3089430
3089431
3089433
3089434
3089436
3089443
3089445
3089448
3089449
3089450
3089458
3089461
3089462
3089463
32541_PM_at
32541_at
5533
8145136
A_14_P119710
A_23_P157495
GE58778
GO:0003824
GO:0004721
GO:0004722
GO:0004723
GO:0005515
GO:0005516
GO:0005737
GO:0005739
GO:0005829
GO:0005955
GO:0006470
GO:0008287
GO:0016192
GO:0016787
GO:0017018
GO:0023052
GO:0033173
GO:0033192
GO:0036211
GO:0043226
GO:0046872
GO:0055085
GO:0070886
GO:0097720
GO:0098793
GO:0098978
GO:0140096
GO:1900242
GO:1900244
GO:1905665
GO:1905949
HMNXSV003014039
ILMN_1690546
PH_hs_0004287
S46622_at
TC08000172.hg
g5031988_3p_s_at
Participates
as a member of
PPP3CA,B,C [cytosol] (Homo sapiens)
as a component of
Calcineurin B complex [cytosol] (Homo sapiens)
Inferred To
ppp3cb [cytosol]
(Xenopus tropicalis)
PPP3CC [cytosol]
(Bos taurus)
PPP3CC [cytosol]
(Canis familiaris)
PPP3CC [cytosol]
(Mus musculus)
PPP3CC [cytosol]
(Sus scrofa)
Ppp3cc [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001230904.1
,
NP_005596.2
,
NP_001230903.1
OpenTargets
ENSG00000120910
HPA
ENSG00000120910-PPP3CC
GeneCards
P48454
Ensembl
ENST00000240139
,
ENSP00000380878
,
ENSP00000240139
,
ENST00000289963
,
ENSP00000289963
,
ENST00000397775
,
ENSG00000120910
PRO
P48454
Pharos - Targets
P48454
PDB
7U0T
HMDB Protein
HMDBP07950
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P24592 IGFBP6
1
IGFBP6 [extracellular region]
(R-HSA-381475)
0.527
3
UniProt:Q9UKA8 RCAN3
1
RCAN3 [cytosol]
(R-HSA-9728800)
0.527
3
UniProt:P59665 DEFA1
9
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
0.527
2
UniProt:P05814 CSN2
1
CSN2 [extracellular region]
(R-HSA-1254293)
0.527
2
UniProt:P49840 GSK3A
3
GSK3A [cytosol]
(R-HSA-198326)
p-S21-GSK3A [cytosol]
(R-HSA-198352)
p-Y279-GSK3A [cytosol]
(R-HSA-9635490)
0.527
3
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