Reactome | S-Farn-Me KRAS4B [cytosol]

S-Farn-Me KRAS4B [cytosol]

Stable Identifier

R-HSA-9654510

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GTPase KRas, RASK_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01116-2 KRAS

Gene Names

KRAS, KRAS2, RASK2

Participates

as a component of

S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Homo sapiens)

Other forms of this molecule

S-Farn-Me KRAS4B [plasma membrane]

S-Farn-Me KRAS4B [endoplasmic reticulum membrane]

S-Farn KRAS4B [endoplasmic reticulum membrane]

S-Farn proKRAS4B [endoplasmic reticulum membrane]

pro-KRAS4B [cytosol]

pS181-S-Farn-Me KRAS4B [plasma membrane]

pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]

Inferred To

S-Farn-Me KRAS4B [cytosol] (Caenorhabditis elegans)

S-Farn-Me KRAS4B [cytosol] (Drosophila melanogaster)

S-Farn-Me KRAS4B [cytosol] (Mus musculus)

S-Farn-Me KRAS4B [cytosol] (Rattus norvegicus)

KRAS [cytosol] (Bos taurus)

KRAS [cytosol] (Canis familiaris)

KRAS [cytosol] (Gallus gallus)

KRAS [cytosol] (Sus scrofa)

Modified Residues

Name

S-farnesyl-L-cysteine methyl ester at 185

Coordinate

185

PsiMod Name

S-farnesyl-L-cysteine methyl ester

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester.

Cross References

RefSeq

NP_203524.1, XP_006719132.1, NP_004976.2, XP_011518955.1

Guide to Pharmacology - Targets

2824

OpenTargets

ENSG00000133703

ENSEMBL

ENST00000256078, ENSP00000256078, ENST00000311936, ENSP00000508921, ENSP00000509238, ENSP00000308495, ENST00000685328, ENSG00000133703, ENST00000688940

ZINC - Substances

RASK_HUMAN

ZINC target

P01116

PRO

P01116

PDB

7R0M, 7RT2, 7SCX, 2MSE, 8VRA, 6PGO, 7EYX, 8G9Q, 6GOD, 7T1F, 6QUX, 6GOM, 4M1O, 7OK3, 5V6S, 6FA2, 8DGT, 4EPT, 7O70, 1N4Q, 6YXW, 5WHA, 5MLA, 6N2K, 6MTA, 7LZ5, 7KFZ, 5UFQ, 6GJ6, 7LC2, 7YV1, 8T71, 5UQW, 9BG1, 4QL3, 8TXJ, 6MQN, 5UK9, 6BOF, 6P8W, 4OBE, 8B78, 5OCT, 6MBQ, 8QW7, 7MQU, 3GFT, 8X6R, 4EPY, 8TBJ, 6P0Z, 4M1S, 6PGP, 6QUV, 5XCO, 7LGI, 8TXE, 4Q02, 5US4, 8FMK, 8WTE, 4LV6, 6M9W, 1N4R, 8DGS, 8AFC, 6F76, 7ACA, 7OO7, 8AZX, 1KZP, 5V9U, 7TLE, 6EPN, 6V6F, 8TY9, 6WGN, 7YCE, 8AZZ, 4TQ9, 1D8E, 8G4H, 8S8C, 7SCW, 8PI0, 6MBT, 4LRW, 5UFE, 4WA7, 4EPR, 4LPK, 5YY1, 1D8D, 4EPX, 6GOE, 7U8H, 8G9P, 6GQW, 4Q01, 7EW9, 6O51, 6MQG, 8G47, 6EPL, 8DNI, 8CPR, 1N4S, 8B69, 1KZO, 9AX6, 4LDJ, 4NMM, 6OB2, 8QVU, 6BP1, 6O36, 6WS4, 8I5E, 6O4Y, 7NY8, 6VC8, 8AZY, 7STF, 7RT1, 7C41, 7RP4, 6E6G, 6PTW, 6ZLI, 7W5R, 6V5L, 8AQ5, 5OCG, 6JTP, 6ZL5, 6ASA, 8I5C, 5O2S, 8TBM, 6GQT, 7VVB, 8T4V, 5VPI, 6W4E, 8TXG, 8CX5, 7TLK, 8G42, 6JTN, 6XHB, 8T74, 8ONV, 8F0M, 8I5D, 6FA3, 5WHD, 8AZR, 6EPO, 6T5B, 5WLB, 7A47, 8TBN, 8DVG, 5W22, 5VPY, 7RP3, 4PZZ, 8QW6, 7ACH, 8AFB, 8JHL, 8STN, 5V6V, 6GJ7, 2MSC, 4M1W, 8WUL, 7RPZ, 8TBL, 6QUW, 8EER, 6P8Z, 4EPW, 8FMJ, 5TB5, 8JJS, 6WS2, 8EIE, 8BE3, 6O4Z, 8VRB, 6JTO, 7F0W, 6MS9, 8EBZ, 7R0Q, 8BLR, 6CCX, 6E6F, 6FA4, 8UDR, 8UN4, 8BE4, 4DSO, 8T73, 4LYJ, 8TXH, 8ECR, 6V65, 7C40, 8VR9, 7A1Y, 7RT4, 5VPZ, 5VQ2, 4Q03, 8STM, 4PZY, 6USZ, 9BFY, 8AQ7, 5KYK, 6B0Y, 6ARK, 6P8X, 8JGD, 7RT5, 6W4F, 8FMI, 5WHE, 6FA1, 6XHA, 6VJJ, 8DNK, 6XGU, 6PQ3, 4LYH, 8UN5, 8T75, 7ACQ, 8UN3, 7LC1, 6EPP, 8TY2, 5WPM, 8G4F, 5VQ0, 6GOF, 8TBF, 4M22, 7A1W, 6QUU, 7RSC, 5VBM, 6H46, 5V9O, 7RP2, 6GJ8, 7KMR, 7OK4, 6YR8, 6UT0, 6CCH, 8QU8, 2MSD, 5O2T, 5WHB, 7YCC, 4LUC, 7EWA, 5V71, 7ROV, 6XGV, 1N4P, 6N2J, 6ASE, 8DNJ, 6TAM, 4L8G, 6GJ5, 6PTS, 5V9L, 7KYZ, 4DSN, 7EWB, 7MDP, 6O46, 8EZG, 8TXK, 5OCO, 6MBU, 5VP7, 5VQ1, 6GQX, 8TBH, 5VQ8, 7A1X, 7RT3, 8R7X, 6H47, 5YXZ, 7ACF, 8AFD, 6T5U, 6B0V, 6P8Y, 4M1T, 5VQ6, 7T47, 7RSE, 8TBK, 8EPW, 4EPV, 8BE5, 6MNX, 7YUZ, 8B6I, 7R0N, 5MLB, 7TLG, 5TAR, 6USX, 6TAN, 8T72, 6OIM, 7Q9U, 8AZV, 5F2E, 8TVK, 6OB3, 8TY8, 6EPM, 6CU6, 4LYF, 6O53, 5USJ, 6CC9, 6GOG, 8B00, 4M21, 4TQA, 6GQY, 8EDY, 8QUG, 4M1Y, 6T5V, 8R7W

HPA

ENSG00000133703-KRAS

GeneCards

KRAS

Pharos - Targets

P01116

Orphanet

KRAS

HMDB Protein

HMDBP08526

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094)	0.695	6
UniProt:Q99755 PIP5K1A	1	PIP5K1A [cytosol] (R-HSA-1806260)	0.661	9
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.615	4
UniProt:Q96II5 Q96II5			0.556	3
UniProt:P50749 RASF2			0.544	2
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.519	2
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971)	0.519	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.483	2
UniProt:P28288 ABCD3	2	ABCD3 [cytosol] (R-HSA-1456459) ABCD3 [peroxisomal membrane] (R-HSA-1456468)	0.483	2
UniProt:P01111 NRAS	20	S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) NRAS [plasma membrane] (R-HSA-62725) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) proNRAS [cytosol] (R-HSA-9647758) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12V [plasma membrane] (R-HSA-9649666)	0.483	2
UniProt:Q7KZI7 MARK2			0.483	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.483	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2

Cite Us!