Reactome | p-CST3 [endoplasmic reticulum lumen]

p-CST3 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956911

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

CST3, Cystatin-C, CYTC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01034 CST3

Gene Names

CST3

Chain

signal peptide:1-26, chain:27-146

Reference Genes

BioGPS Gene:1471 CST3

COSMIC (genes):CST3 CST3

CTD Gene:1471 CST3

dbSNP Gene:1471 CST3

ENSEMBL:ENSG00000101439 CST3

HGNC:2475 CST3

KEGG Gene (Homo sapiens):1471 CST3

Monarch:1471 CST3

NCBI Gene:1471 CST3

OMIM:604312 CST3

UCSC:P01034 CST3

Reference Transcript

Other Identifiers

0000580133

11715358_x_at

11757288_s_at

1471

16917939

201360_at

230343_at

237623_at

3901297

3901298

3901299

3901300

3901301

3901302

3901303

3901308

3901309

3901310

3901311

3901312

3901313

3901314

3901318

3901319

3901320

3901321

3901322

3901323

45850_at

8065403

A_24_P216294

A_33_P3228266

A_33_P3228271

GE594855

GE59773

GE868472

GO:0001540

GO:0002020

GO:0002376

GO:0003674

GO:0004866

GO:0004869

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005886

GO:0006464

GO:0006810

GO:0006950

GO:0006952

GO:0008150

GO:0009056

GO:0010466

GO:0010711

GO:0010716

GO:0010951

GO:0016192

GO:0019899

GO:0030198

GO:0030234

GO:0030414

GO:0031410

GO:0034103

GO:0042802

GO:0043226

GO:0043312

GO:0043687

GO:0044267

GO:0045861

GO:0048856

GO:0060311

GO:0060313

GO:0070062

GO:0097435

GO:1904724

GO:1904813

GO:1990000

HMNXSV003024512

HMNXSV003051337

Hs.211061.0.A1_3p_at

Hs.28773.0.A1_3p_at

ILMN_1800354

M27891_at

PH_hs_0015700

TC20000715.hg

g4503106_3p_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

CST3 [endoplasmic reticulum lumen]

CST3 [tertiary granule lumen]

CST3 [extracellular region]

CST3 [ficolin-1-rich granule lumen]

Variant cystatin-C [extracellular region]

Inferred To

phospho-cpi-2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-LOC607874 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-cst3 [endoplasmic reticulum lumen] (Danio rerio)

phospho-cst3 [endoplasmic reticulum lumen] (Xenopus tropicalis)

phospho-p-CST3 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-CST3 [endoplasmic reticulum lumen] (Bos taurus)

phospho-CST3 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Cst3 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Cst3 [endoplasmic reticulum lumen] (Rattus norvegicus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001275543.1, NP_000090.1

OpenTargets

ENSG00000101439

HPA

ENSG00000101439-CST3

GeneCards

P01034

Ensembl

ENSP00000381446, ENST00000398409, ENST00000376925, ENSP00000381448, ENSG00000101439, ENST00000398411, ENSP00000366124

PRO

P01034

Pharos - Targets

P01034

Orphanet

15814

PDB

6ROA, 3QRD, 6RPV, 3GAX, 3NX0, 3SVA, 3S67, 1TIJ, 1G96, 3PS8, 1R4C

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-711) [extracellular region] (R-HSA-976740) APP-C99 [cytosol] (R-HSA-9617603) APP(672-711) [cytosol] (R-HSA-877188) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(688-770) [plasma membrane] (R-HSA-9010028) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-687) [extracellular region] (R-HSA-9010033) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3