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ZNF423 [nucleoplasm]
Stable Identifier
R-HSA-3222318
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, Smad- and Olf-interacting zinc finger protein, KIAA0760, NPHP14, OAZ
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423 (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423 (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PRDM16 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
SMAD1:SMAD4 trimer binds ZNF423 (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423 binds EBF2 at EBF2-target gene loci (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, DIO2 gene, ELOVL3 gene) [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:ELOVL3 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PRDM16 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423 recruits NuRD to EBF2 target genes (Homo sapiens)
NuRD:ZNF423:EBF2,EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, UCP1 gene, (CIDEA gene, DIO2 gene) [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, UCP1 gene, (CIDEA gene, DIO2 gene) [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
ZNF423 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q2M1K9 ZNF423
Gene Names
ZNF423, KIAA0760, NPHP14, OAZ
Chain
chain:1-1284
Reference Genes
BioGPS Gene:23090 ZNF423
COSMIC (genes):ZNF423 ZNF423
CTD Gene:23090 ZNF423
dbSNP Gene:23090 ZNF423
ENSEMBL:ENSG00000102935 ZNF423
HGNC:16762 ZNF423
Monarch:23090 ZNF423
NCBI Gene:23090 ZNF423
OMIM:604557 ZNF423
UCSC:Q2M1K9 ZNF423
Reference Transcript
RefSeq:XM_005255856.4 ZNF423
RefSeq:XM_017023077.1 ZNF423
RefSeq:NM_015069.4 ZNF423
RefSeq:XM_017023078.1 ZNF423
RefSeq:NM_001271620.2 ZNF423
Other Identifiers
11730352_x_at
11750380_a_at
11750381_x_at
11758678_s_at
16826389
214761_PM_at
214761_at
23090
34950_at
3690830
3690831
3690832
3690833
3690843
3690844
3690863
3690865
3690905
3690906
3690918
3690927
3690928
3690929
3690930
3690931
3690949
3690951
3690957
3690958
3690961
50050_at
8001337
83639_at
A_23_P88880
GE53468
GE570656
GO:0000978
GO:0000981
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0007219
GO:0007224
GO:0007399
GO:0021930
GO:0030154
GO:0030513
GO:0043226
GO:0043565
GO:0044782
GO:0045892
GO:0045893
GO:0046872
GO:0048856
GO:0050872
GO:0050873
GO:0060271
GO:0061512
GO:0120163
GO:0140110
HMNXSV003055543
Hs.137168.0.S1_3p_at
ILMN_1763602
ILMN_2154950
PH_hs_0022735
TC16001102.hg
Participates
as an input of
SMAD1:SMAD4 trimer binds ZNF423 (Homo sapiens)
ZNF423 binds EBF2 at EBF2-target gene loci (Homo sapiens)
as a component of
ZNF423:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PRDM16 gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:ELOVL3 gene [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD
(Homo sapiens)
ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423
(Homo sapiens)
DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423
(Homo sapiens)
Cross References
ENSEMBL
ENSP00000457664
,
ENST00000561648
,
ENSP00000457928
,
ENSP00000455426
,
ENST00000562871
,
ENST00000562520
OpenTargets
ENSG00000102935
HPA
ENSG00000102935-ZNF423
PRO
Q2M1K9
Pharos - Targets
Q2M1K9
GlyGen
Q2M1K9
PDB
2MDG
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.553
2
UniProt:Q9P2Y4 ZN219
0.527
2
UniProt:Q96DA0 PAUF
0.527
2
UniProt:Q8WWY6 MB3L1
0.527
2
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.527
3
UniProt:P10276 RARA
3
RARA [nucleoplasm]
(R-HSA-446164)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
0.524
2
UniProt:O15078 CEP290
3
CEP290 [extracellular region]
(R-HSA-6806291)
CEP290 [specific granule lumen]
(R-HSA-6799524)
CEP290 [cytosol]
(R-HSA-380275)
0.508
3
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