Reactome | APCS(20-223) [extracellular region]

APCS(20-223) [extracellular region]

Stable Identifier

R-HSA-976737

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Serum amyloid P-component, APCS, SAMP_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02743 APCS

Gene Names

APCS, PTX2

Chain

signal peptide:1-19, chain:20-223, chain:20-222

Reference Genes

BioGPS Gene:325 APCS

COSMIC (genes):APCS APCS

CTD Gene:325 APCS

dbSNP Gene:325 APCS

ENSEMBL:ENSG00000132703 APCS

HGNC:584 APCS

KEGG:hsa:325 APCS

Monarch:325 APCS

NCBI Gene:325 APCS

OMIM:104770 APCS

UCSC:P02743 APCS

Reference Transcript

RefSeq:NM_001639.3 APCS

Other Identifiers

11727405_a_at

16672452

206350_PM_at

206350_at

2362652

2362653

2362654

2362655

2362656

2362657

2362658

2362660

325

38890_at

7906458

A_14_P200044

A_23_P96827

D00097_s_at

GE520389

GE63034

GO:0001849

GO:0002376

GO:0002674

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0006457

GO:0006953

GO:0006954

GO:0030246

GO:0030312

GO:0031012

GO:0042802

GO:0043226

GO:0044869

GO:0044871

GO:0045087

GO:0045656

GO:0046597

GO:0046790

GO:0046872

GO:0048525

GO:0051082

GO:0051131

GO:0061045

GO:0062023

GO:0065003

GO:0070062

GO:0072562

GO:0098542

GO:1903016

GO:1903019

HMNXSV003047677

ILMN_1708833

PH_hs_0000260

TC01001354.hg

g4502132_3p_at

Participates

as an input of

Serum amyloid P-component forms homopentamers (Homo sapiens)

as a component of

Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)

Cross References

Guide to Pharmacology - Targets

2839

ENSEMBL

ENST00000255040, ENSP00000255040

OpenTargets

ENSG00000132703

HPA

ENSG00000132703-APCS

PRO

P02743

Pharos - Targets

P02743

GlyGen

P02743

HMDB Protein

HMDBP07988

PDB

1SAC, 1LGN, 4AVS, 4AYU, 4AVT, 1GYK, 3D5O, 2A3X, 2W08, 4AVV, 2A3Y, 2A3W, 3KQR

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02743 APCS	1	APCS(20-223) [extracellular region] (R-HSA-976737)	0.806	8
UniProt:Q9Y5P4-1 CERT1			0.618	6
UniProt:Q9Y5P4-2 CERT1	5	p-S132-CERT1-2 [cytosol] (R-HSA-429704) p-S,S132,T-CERT1-2 [cytosol] (R-HSA-429695) p-S,S132,T-CERT1-2 [endoplasmic reticulum membrane] (R-HSA-429727) CERT1-2 [endoplasmic reticulum membrane] (R-HSA-429665) CERT1-2 [cytosol] (R-HSA-429712)	0.558	4
UniProt:Q15699 ALX1			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9Y5P4 CERT1			0.463	2

Cite Us!