Reactome | STXBP1 [plasma membrane]

STXBP1 [plasma membrane]

Stable Identifier

R-HSA-2980862

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Syntaxin-binding protein 1, STXB1_HUMAN

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External Reference Information

External Reference

UniProt:P61764 STXBP1

Gene Names

STXBP1, UNC18A

Chain

chain:1-594

Reference Genes

BioGPS Gene:6812 STXBP1

COSMIC (genes):STXBP1 STXBP1

CTD Gene:6812 STXBP1

dbSNP Gene:6812 STXBP1

ENSEMBL:ENSG00000136854 STXBP1

ENSEMBL_homo_sapiens_GENE:ENSG00000136854.25 STXBP1

HGNC:11444 STXBP1

KEGG Gene (Homo sapiens):6812 STXBP1

Monarch:6812 STXBP1

NCBI Gene:6812 STXBP1

OMIM:602926 STXBP1

UCSC:P61764 STXBP1

Reference Transcript

Other Identifiers

11729699_a_at

11729700_a_at

11729701_x_at

11746786_a_at

17089371

202260_PM_s_at

202260_s_at

3189933

3189934

3189942

3189943

3189946

3189947

3189948

3189951

3189953

3189954

3189955

3189957

3189958

3189959

3189960

3189961

3189962

3189963

3189964

3189965

3189967

3189968

3189969

3189970

3189971

3189972

33942_s_at

6812

8158059

A_24_P201171

D63851_at

GE79675

GO:0000149

GO:0002376

GO:0002576

GO:0003006

GO:0003723

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006886

GO:0006887

GO:0006904

GO:0007155

GO:0007269

GO:0007274

GO:0007412

GO:0010807

GO:0012501

GO:0015031

GO:0016020

GO:0016082

GO:0016188

GO:0016192

GO:0017075

GO:0019901

GO:0019904

GO:0019905

GO:0022414

GO:0023052

GO:0030141

GO:0030154

GO:0030424

GO:0031091

GO:0031333

GO:0031338

GO:0031410

GO:0031630

GO:0032229

GO:0032355

GO:0032991

GO:0035493

GO:0035542

GO:0042060

GO:0042802

GO:0043226

GO:0043274

GO:0043306

GO:0043524

GO:0045335

GO:0045921

GO:0045956

GO:0048471

GO:0048787

GO:0048856

GO:0050821

GO:0051402

GO:0051649

GO:0060292

GO:0061024

GO:0065003

GO:0070062

GO:0070527

GO:0071346

GO:0072659

GO:0098542

GO:0098688

GO:0098793

GO:0098794

GO:0098831

GO:0098888

GO:0098978

GO:0099523

GO:0099525

GO:0106022

GO:1903296

GO:2000367

HMNXSV003011439

ILMN_1728747

ILMN_1810657

ILMN_2414878

PH_hs_0023811

TC09000668.hg

g4507296_3p_a_at

Participates

as an output of

Exocytosis of Insulin (Homo sapiens)

as a component of

STX1A:STXBP1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

STXBP1 [cytosol]

Cross References

RefSeq

NP_003156.1, NP_001027392.1

OpenTargets

ENSG00000136854

HPA

ENSG00000136854-STXBP1

GeneCards

P61764

Ensembl

ENST00000373299, ENST00000373302, ENSG00000136854, ENSP00000362399, ENSP00000362396

PRO

P61764

Pharos - Targets

P61764

Orphanet

17663

HMDB Protein

HMDBP08589

PDB

6L03

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N4C7 STX19			0.85	11
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.805	9
UniProt:O75558 STX11			0.782	8
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.718	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	7
UniProt:P21917 DRD4	1	DRD4 [plasma membrane] (R-HSA-390809)	0.556	3
UniProt:Q6IPU0 CENPP	2	CENPP [nucleoplasm] (R-HSA-606341) CENPP [cytosol] (R-HSA-375299)	0.556	3
UniProt:Q0VDD7 BRME1			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q96C24 SYTL4	2	SYTL4 [platelet alpha granule membrane] (R-HSA-8862959) SYTL4 [plasma membrane] (R-HSA-8862971)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.556	3
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.556	3
UniProt:Q8N0Z3 SPICE			0.556	3
IntAct:EBI-25911596 CCSB			0.556	3
UniProt:P60880 SNAP25	7	SNAP25(1-197) [plasma membrane] (R-HSA-3004546) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25 [plasma membrane] (R-HSA-2029017)	0.527	2
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.527	4
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.499	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.463	10

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