Reactome | CSNK1D [nucleoplasm]

CSNK1D [nucleoplasm]

Stable Identifier

R-HSA-421305

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Casein kinase I isoform delta, KC1D_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P48730 CSNK1D

Gene Names

CSNK1D, HCKID

Chain

chain:1-415

Reference Genes

BioGPS Gene:1453 CSNK1D

COSMIC (genes):CSNK1D CSNK1D

CTD Gene:1453 CSNK1D

dbSNP Gene:1453 CSNK1D

ENSEMBL:ENSG00000141551 CSNK1D

ENSEMBL_homo_sapiens_GENE:ENSG00000141551.15 CSNK1D

HGNC:2452 CSNK1D

KEGG Gene (Homo sapiens):1453 CSNK1D

Monarch:1453 CSNK1D

NCBI Gene:1453 CSNK1D

OMIM:600864 CSNK1D

UCSC:P48730 CSNK1D

Reference Transcript

Other Identifiers

11739917_a_at

11750012_a_at

11750013_x_at

11754298_x_at

11763311_a_at

1453

16850189

207945_PM_s_at

207945_s_at

208774_PM_at

208774_at

36949_at

3774830

3774831

3774835

3774836

3774840

3774842

3774845

3774846

3774847

3774848

3774852

3774853

3774860

3774865

3774866

3774867

493_at

8019463

A_23_P207896

A_24_P318544

A_33_P3324765

GE59058

GO:0000166

GO:0001934

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0005886

GO:0005929

GO:0006468

GO:0006897

GO:0007010

GO:0007020

GO:0007030

GO:0007059

GO:0007165

GO:0016020

GO:0016055

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0030163

GO:0032436

GO:0032922

GO:0033116

GO:0034067

GO:0036064

GO:0036211

GO:0042752

GO:0043226

GO:0044782

GO:0045296

GO:0048208

GO:0048471

GO:0048511

GO:0048856

GO:0050321

GO:0051225

GO:0061024

GO:0061512

GO:0065003

GO:0071539

GO:0090263

GO:0106310

GO:0140096

GO:1904948

GO:1905515

GO:1990090

GO:2000052

HMNXSV003036662

HMNXSV003052814

Hs.75852.1.S2_3p_at

ILMN_1720708

ILMN_2286870

PH_hs_0027416

TC17001976.hg

U29171_at

g4503090_3p_a_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

as a candidate of

CSNK1E,CSNK1D [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]

CSNK1D [cytosol]

Inferred To

Ghost homologue of CSNK1D [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of CSNK1D [nucleoplasm] (Drosophila melanogaster)

Csnk1d [nucleoplasm] (Mus musculus)

CSNK1D [nucleoplasm] (Bos taurus)

CSNK1D [nucleoplasm] (Canis familiaris)

CSNK1D [nucleoplasm] (Danio rerio)

CSNK1D [nucleoplasm] (Dictyostelium discoideum)

CSNK1D [nucleoplasm] (Gallus gallus)

CSNK1D [nucleoplasm] (Plasmodium falciparum)

CSNK1D [nucleoplasm] (Rattus norvegicus)

CSNK1D [nucleoplasm] (Saccharomyces cerevisiae)

CSNK1D [nucleoplasm] (Schizosaccharomyces pombe)

CSNK1D [nucleoplasm] (Sus scrofa)

CSNK1D [nucleoplasm] (Xenopus tropicalis)

Homologues of CSNK1D [nucleoplasm] (Danio rerio)

Homologues of CSNK1D [nucleoplasm] (Plasmodium falciparum)

Cross References

RefSeq

NP_001884.2, NP_620693.1

ZINC - World Drugs

KC1D_HUMAN

Guide to Pharmacology - Targets

1997

OpenTargets

ENSG00000141551

ZINC - FDA approved

KC1D_HUMAN

ZINC - Substances

KC1D_HUMAN

ZINC target

P48730

ZINC - Biogenic

KC1D_HUMAN

PRO

P48730

PDB

6RCG, 5IH6, 6PXO, 6RCH, 3UYS, 4KB8, 6RU8, 6PXN, 5IH5, 8IZC, 7QRB, 6RU7, 3UZP, 4KBK, 6RU6, 4HNF, 4TN6, 5W4W, 6F26, 6F1W, 8D7P, 4KBC, 7QRA, 6HMR, 6GZM, 5IH4, 4TWC, 7QR9, 5OKT, 8D7O, 8D7N, 7P7H, 7NZY, 7P7G, 7P7F, 6HMP, 3UYT, 5MQV, 4HGT, 6PXP, 8D7M, 4TW9, 4KBA

ZINC - Investigational

KC1D_HUMAN

ZINC - Metabolites

KC1D_HUMAN

HPA

ENSG00000141551-CSNK1D

GeneCards

P48730

Ensembl

ENST00000392334, ENSP00000324464, ENSG00000141551, ENSP00000376146, ENST00000314028

Pharos - Targets

P48730

Orphanet

17580

ZINC - Predictions - Purchasable

KC1D_HUMAN

HMDB Protein

HMDBP09458

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15055 PER2	4	p-S-PER2 [cytosol] (R-HSA-400331) p-S-PER2 [nucleoplasm] (R-HSA-3325591) PER2 [cytosol] (R-HSA-400399) Ub-p-S-PER2 [cytosol] (R-HSA-517835)	0.756	6
UniProt:Q14C86 GAPVD1	1	GAPVD1 [cytosol] (R-HSA-8871123)	0.669	4
UniProt:P23508 CRCM			0.669	5
UniProt:Q5T7W0 ZN618			0.666	4
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.666	4
UniProt:Q6ZRV2 FA83H			0.643	5
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.643	3
UniProt:Q96LR2 LURA1			0.61	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.61	6
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.569	3
UniProt:Q9C026 TRIM9	1	TRIM9 [cytosol] (R-HSA-976054)	0.556	3
UniProt:Q6PGQ1 DRIC1			0.556	3
UniProt:O75382 TRIM3	1	TRIM3 [cytosol] (R-HSA-5624344)	0.556	3
UniProt:O60447 EVI5			0.556	3
UniProt:Q9H2S9 IKZF4			0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q49A88-3 CCDC14			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q99996 AKAP9	3	AKAP9(1-1118)-BRAF(381-766) fusion [cytosol] (R-HSA-6802267) AKAP9(1-1118)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802514) AKAP9 [cytosol] (R-HSA-380260)	0.527	3
UniProt:Q5T0W9 FAM83B	1	FAM83B [cytosol] (R-HSA-9715184)	0.527	3
UniProt:Q7Z5H3 ARHGAP22	1	ARHGAP22 [cytosol] (R-HSA-200762)	0.527	2
UniProt:Q8TC76 F110B			0.527	2
UniProt:Q9Y343 SNX24			0.527	3
UniProt:Q8WVL7 ANR49			0.527	2
UniProt:Q6PEV8 F199X			0.527	2
UniProt:Q9H4H8 FAM83D	1	FAM83D [cytosol] (R-HSA-9852722)	0.527	2
UniProt:Q7Z7G8 VP13B			0.527	3
UniProt:Q9H9R9 DBND1			0.527	2
UniProt:Q9UIM3 FKBPL	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.527	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.527	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.527	2
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.527	3
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	2

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