7K-BACE1(46-501) [Golgi-associated vesicle lumen]

Stable Identifier
R-HSA-5693106
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN
7K-BACE1(46-501) [Golgi-associated vesicle lumen] icon
External Reference Information
External Reference
Gene Names
BACE1, BACE, KIAA1149
Chain
signal peptide:1-21, propeptide:22-45, chain:46-501
Other Identifiers
0005360487
11716390_a_at
11716391_a_at
11749940_a_at
11753657_a_at
11753658_x_at
11754653_a_at
16358
16744822
1FKN
1M4H
1PY1
1SGZ
1TQF
1UJJ
1UJK
1W50
1W51
1XN2
1XN3
1XS7
1YM2
1YM4
217904_s_at
222462_s_at
222463_s_at
224335_s_at
23621
2B8L
2B8V
2F3E
2F3F
2FDP
2G94
2HIZ
2HM1
2IQG
2IRZ
2IS0
2NTR
2OAH
2OF0
2OHK
2OHL
2OHM
2OHN
2OHP
2OHQ
2OHR
2OHS
2OHT
2OHU
2P4J
2P83
2P8H
2PH6
2PH8
2Q11
2Q15
2QK5
2QMD
2QMF
2QMG
2QP8
2QU2
2QU3
2QZK
2QZL
2VA5
2VA6
2VA7
2VIE
2VIJ
2VIY
2VIZ
2VJ6
2VJ7
2VJ9
2VKM
2VNM
2VNN
2WEZ
2WF0
2WF1
2WF2
2WF3
2WF4
2WJO
2XFI
2XFJ
2XFK
2ZDZ
2ZE1
2ZHR
2ZHS
2ZHT
2ZHU
2ZHV
2ZJH
2ZJI
2ZJJ
2ZJK
2ZJL
2ZJM
2ZJN
3393256
3393258
3393259
3393260
3393261
3393262
3393263
3393264
3393265
3393267
3393268
3393270
3393273
3393276
3393277
3393279
3393280
3393281
3393282
3393284
3393295
3393296
3393297
3393298
3BRA
3BUF
3BUG
3BUH
3CIB
3CIC
3CID
3CKP
3CKR
3DM6
3DUY
3DV1
3DV5
3EXO
3FKT
3H0B
3HVG
3HW1
3I25
3IGB
3IN3
3IN4
3IND
3INE
3INF
3INH
3IVH
3IVI
3IXJ
3IXK
3K5C
3K5D
3K5F
3K5G
3KMX
3KMY
3KN0
3KYR
3L38
3L3A
3L58
3L59
3L5B
3L5C
3L5D
3L5E
3L5F
3LHG
3LNK
3LPI
3LPJ
3LPK
3MSJ
3MSK
3MSL
3N4L
3NSH
3OHF
3OHH
3OOZ
3PI5
3QBH
3QI1
3R1G
3R2F
3RSV
3RSX
3RTH
3RTM
3RTN
3RU1
3RVI
3S2O
3S7L
3S7M
3SKF
3SKG
3TPJ
3TPL
3TPP
3TPR
3U6A
3UDH
3UDJ
3UDK
3UDM
3UDN
3UDP
3UDQ
3UDR
3UDY
3UFL
3UQP
3UQR
3UQU
3UQW
3UQX
3VEU
3VF3
3VG1
3VV6
3VV7
3VV8
3WB4
3WB5
3ZMG
3ZOV
44849_at
45790_at
4ACU
4ACX
4AZY
4B00
4B05
4B0Q
4B1C
4B1D
4B1E
4B70
4B72
4B77
4B78
4BEK
4BFD
4D83
4D85
4D88
4D89
4D8C
4DH6
4DI2
4DJU
4DJV
4DJW
4DJX
4DJY
4DPF
4DPI
4DUS
4DV9
4DVF
4EWO
4EXG
4FCO
4FGX
4FM7
4FM8
4FRI
4FRJ
4FRK
4FRS
4FS4
4FSE
4FSL
4GID
4GMI
4H1E
4H3F
4H3G
4H3I
4H3J
4HA5
4HZT
4I0D
4I0E
4I0F
4I0G
4I0H
4I0I
4I0J
4I0Z
4I10
4I11
4I12
4I1C
4IVS
4IVT
4J0P
4J0T
4J0V
4J0Y
4J0Z
4J17
4J1C
4J1E
4J1F
4J1H
4J1I
4J1K
4JOO
4JP9
4JPC
4JPE
4K8S
4K9H
4KE0
4KE1
4L7G
4L7H
4L7J
4LC7
4LXA
4LXK
4LXM
4N00
4PZW
4PZX
4R5N
4R8Y
4R91
4R92
4R93
4R95
4RCD
4RCE
4RCF
4RRN
4RRO
4RRS
4TRW
4TRY
4TRZ
4WTU
4WY1
4WY6
4X2L
4X7I
4XKX
4XXS
4YBI
4ZPE
4ZPF
4ZPG
4ZSM
4ZSP
4ZSQ
4ZSR
5CLM
5DQC
5ENK
5ENM
5EZX
5EZZ
5F00
5F01
5HD0
5HDU
5HDV
5HDX
5HDZ
5HE4
5HE5
5HE7
5HTZ
5HU0
5HU1
5I3V
5I3W
5I3X
5I3Y
5IE1
5KQF
5KR8
5MBW
5MCO
5MCQ
5MXD
5T1U
5T1W
5TOL
5UYU
5V0N
5YGX
5YGY
6BFD
6BFE
6BFW
6BFX
6C2I
6DHC
6DMI
6EJ2
6EJ3
6EQM
6FGY
7951910
A0A024R3D5
A0A024R3D7
A0A024R3E8
A0A024R3F9
A_33_P3240936
A_33_P3240941
AAF04142
AAF13715
AAF17079
AAF18982
AAF26367
AAH65492
AAK38374
AAK38375
AAY16982
AB032975
AB050436
AB050437
AB050438
ACA05927
AF190725
AF200193
AF200343
AF201468
AF204943
AF338816
AF338817
AK296015
AK296535
AP000892
B7Z3K2
B7Z3Z4
BAA86463
BAB40931
BAB40932
BAB40933
BACE1
BACE1-201
BACE1-202
BACE1-203
BACE1-204
BACE1-207
BACE1-209
BAH12238
BAH12380
BC065492
CAB016358
CCDS44739
CCDS44740
CCDS44741
CCDS55786
CCDS55787
CCDS8383
CH471065
DQ007053
E9PJG7
EAW67308
EAW67309
EAW67310
EAW67311
EAW67312
EAW67313
EAW67315
EAW67316
EAW67317
EF444940
ENSG00000186318
ENSP00000318585
ENSP00000402228
ENSP00000403685
ENSP00000422461
ENSP00000424536
ENSP00000475405
ENST00000313005
ENST00000313005.10
ENST00000392937
ENST00000392937.10
ENST00000428381
ENST00000428381.6
ENST00000445823
ENST00000445823.6
ENST00000510630
ENST00000510630.5
ENST00000513780
ENST00000513780.5
EntrezGene:23621
EntrezGene:BACE1
g13568406_3p_s_at
g6118538_3p_a_at
g6912265_3p_a_at
GE58458
GO:0001540
GO:0003674
GO:0004175
GO:0004190
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005771
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005802
GO:0005886
GO:0005887
GO:0006508
GO:0006509
GO:0006810
GO:0007267
GO:0008021
GO:0008150
GO:0008219
GO:0008233
GO:0008798
GO:0009056
GO:0009314
GO:0009986
GO:0010008
GO:0010288
GO:0016020
GO:0016021
GO:0016192
GO:0016787
GO:0019899
GO:0030163
GO:0030424
GO:0030425
GO:0030659
GO:0031410
GO:0034641
GO:0043025
GO:0043226
GO:0043525
GO:0044267
GO:0045121
GO:0050435
GO:0050804
GO:0050877
GO:0050966
GO:0055037
GO:0060134
GO:0070931
GO:0071280
GO:0071287
GO:0098686
GO:0098793
GO:1904646
GO:2000300
H0YDX0
HGNC:933
Hs.49349.0.S3_3p_a_at
ILMN_1797804
ILMN_2320349
IPR001461
IPR001969
IPR009119
IPR009120
IPR021109
IPR033121
IPR033874
MIM:604252
NM_001207048
NM_001207049
NM_012104
NM_138971
NM_138972
NM_138973
NP_001193977
NP_001193978
NP_036236
NP_620427
NP_620428
NP_620429
PF00026
PH_hs_0003439
PR00792
PR01815
PR01816
TC11002335.hg
TC11003367.hg
TC11003368.hg
U3KPS1
UPI000002A4AC
UPI000002A4AD
UPI000002A4AE
UPI0000048186
UPI0000EE3A21
UPI0001914CBB
Participant Of
Other forms of this molecule
Modified Residues
Name
N6-acetyl-L-lysine at 126
Coordinate
126
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 275
Coordinate
275
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 279
Coordinate
279
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 285
Coordinate
285
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 299
Coordinate
299
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 300
Coordinate
300
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 307
Coordinate
307
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
2HM1, 3PI5, 3L5D, 3ZOV, 3INF, 3DUY, 4L7G, 3RSX, 4J17, 3SKG, 5I3V, 2PH8, 2P8H, 1W51, 5ENK, 2ZDZ, 4B78, 3UDN, 4DJV, 4JPC, 4DVF, 3DV5, 4ACX, 3K5C, 2WEZ, 5V0N, 3FKT, 2PH6, 4J0P, 3VV7, 5EZX, 4ACU, 3UDM, 4I0F, 3NSH, 2ZJM, 3VF3, 4J1F, 2F3F, 5HE5, 3EXO, 4FS4, 2VIJ, 2QP8, 2ZHS, 2IQG, 2OHM, 3TPP, 2OF0, 2OHU, 2ZJN, 4DUS, 3N4L, 4FRJ, 4J1I, 3UQU, 5IE1, 3L58, 5MCO, 3VV8, 3LHG, 4R91, 3VEU, 4ZSQ, 4ZPG, 3VG1, 2WF3, 6EJ3, 6C2I, 3IVH, 4J1K, 3H0B, 4DJW, 3LPI, 4FSL, 3RVI, 4R95, 2VKM, 2ZJL, 4KE1, 3SKF, 4FSE, 5HDV, 4DPF, 3IND, 6BFD, 4I0Z, 3CKR, 3BUF, 2P83, 5HE4, 1PY1, 4K9H, 4RRS, 4EWO, 3INE, 4J0V, 4DV9, 4XXS, 2IS0, 5T1U, 2Q15, 3BUG, 2VJ6, 4TRY, 1UJJ, 2WF2, 3BRA, 2QU3, 2G94, 3UFL, 6BFW, 2VIE, 4H3G, 4RCF, 1TQF, 2QK5, 2FDP, 4JP9, 3IGB, 4BEK, 3UQR, 2NTR, 1FKN, 4R8Y, 4DJX, 4WTU, 4L7J, 4PZX, 1YM2, 4EXG, 3RSV, 1W50, 4DPI, 2ZHR, 3VV6, 2VA6, 3L38, 2ZHV, 4J1E, 4H3I, 4D85, 3LPK, 3L5C, 2B8L, 4BFD, 3UDK, 4J1H, 4B00, 3UDY, 5KQF, 1UJK, 2WJO, 5HTZ, 3IN4, 5F01, 3MSL, 2VIZ, 5T1W, 4LC7, 4GID, 3L3A, 3QBH, 4FRI, 1XN3, 3TPL, 2ZJK, 4DJY, 4YBI, 4ZPF, 2QMG, 6EJ2, 2Q11, 3S2O, 2OHT, 4I0J, 3CKP, 4LXA, 4I0E, 5YGY, 4R93, 3RTM, 3LPJ, 2OHS, 4D88, 2OAH, 1XS7, 4I11, 4RRO, 3WB4, 2WF1, 4J0T, 4I0G, 3OHH, 2IRZ, 4FM7, 3LNK, 2OHL, 4TRW, 4B05, 4J0Z, 4GMI, 5HDZ, 4AZY, 3HW1, 2QU2, 3U6A, 5MBW, 3RU1, 4L7H, 1YM4, 4R5N, 2ZHU, 4WY6, 6EQM, 4B0Q, 2XFJ, 3UQP, 1SGZ, 3RTN, 3UQX, 3L5B, 3L5F, 3ZMG, 4D89, 2P4J, 4JPE, 2B8V, 2OHR, 4D83, 2XFK, 5F00, 2VA5, 4FM8, 6BFE, 2ZJJ, 5HE7, 5YGX, 2QZK, 3CID, 4I0I, 3HVG, 3R2F, 4HZT, 3UDJ, 4ZSP, 3K5G, 5HU1, 3S7M, 3KMY, 2OHP, 2OHK, 4FGX, 4N00, 2XFI, 4KE0, 2VIY, 4B1C, 2QMF, 5MXD, 4D8C, 2VJ9, 3TPJ, 2WF0, 3DM6, 2VNN, 5I3Y, 6FGY, 5HDU, 4XKX, 3UDR, 4I10, 2QZL, 4B70, 4RCE, 3OOZ, 3CIC, 4HA5, 2ZJI, 3MSK, 2HIZ, 3I25, 3IN3, 4JOO, 4LXM, 3QI1, 4IVT, 3IXK, 2OHQ, 4J0Y, 3OHF, 2ZHT, 2F3E, 3RTH, 4H3F, 4WY1, 3KYR, 4B1D, 4K8S, 4TRZ, 4PZW, 4I1C, 5I3W, 3INH, 6BFX, 2ZE1, 6DHC, 3UDH, 4FCO, 3KN0, 2WF4, 4B72, 4J1C, 4IVS, 3CIB, 4H3J, 5ENM, 1M4H, 4H1E, 5DQC, 3K5D, 5HD0, 2VNM, 3UQW, 5EZZ, 4DH6, 3K5F, 6DMI, 4ZPE, 4ZSM, 4I0H, 4FRK, 4I12, 3KMX, 4R92, 5HU0, 4B1E, 3UDP, 4X2L, 5MCQ, 3BUH, 5TOL, 3DV1, 4ZSR, 3L5E, 4RRN, 1XN2, 4DJU, 5CLM, 4B77, 4DI2, 2VA7, 3L59, 4X7I, 2OHN, 4I0D, 3IVI, 2ZJH, 3WB5, 3S7L, 5I3X, 3MSJ, 5KR8, 5UYU, 4LXK, 2VJ7, 3IXJ, 2QMD, 4FRS, 4RCD, 3R1G, 3UDQ, 5HDX, 3TPR
ZINC - Investigational
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P05067 APP  20 0.797 8
 UniProt:Q9UJY5 GGA1  2 0.684 4
 UniProt:P49768 PSEN1  6 0.639 6
 UniProt:P10997 IAPP  2 0.558 2
 UniProt:Q9Y287 ITM2B  1 0.556 4
 UniProt:Q9UJY4 GGA2  2 0.544 2
 UniProt:Q9NZ52 GGA3  3 0.544 2
 UniProt:Q03721 KCNC4  1 0.524 3
 UniProt:Q8BNX1  1 0.524 2
 UniProt:O14672 ADAM10  6 0.508 3
 UniProt:Q9UNH7 SNX6      0.499 2
 UniProt:Q14254 FLOT2  1 0.499 2