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PLAU(179-431) [plasma membrane]
Stable Identifier
R-HSA-158970
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
urokinase plasminogen activator chain B
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(179-431) [plasma membrane] (Homo sapiens)
urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(179-431) [plasma membrane] (Homo sapiens)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(179-431) [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1 [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(179-431) [plasma membrane] (Homo sapiens)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(179-431) [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1:SERPINB2 [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(179-431) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00749 PLAU
Gene Names
PLAU
Chain
signal peptide:1-20, chain:21-431, chain:21-177, chain:156-177, chain:179-431
Reference Genes
BioGPS Gene:5328 PLAU
COSMIC (genes):PLAU PLAU
CTD Gene:5328 PLAU
dbSNP Gene:5328 PLAU
ENSEMBL:ENSG00000122861 PLAU
HGNC:9052 PLAU
KEGG:hsa:5328 PLAU
Monarch:5328 PLAU
NCBI Gene:5328 PLAU
OMIM:191840 PLAU
UCSC:P00749 PLAU
Reference Transcript
RefSeq:XM_011539866.2 PLAU
RefSeq:NM_001319191.1 PLAU
RefSeq:NM_001145031.2 PLAU
RefSeq:NM_002658.4 PLAU
Other Identifiers
11717154_a_at
11717886_a_at
11754119_a_at
16706180
205479_PM_s_at
205479_s_at
211668_PM_s_at
211668_s_at
3252039
3252040
3252042
3252043
3252044
3252045
3252046
3252047
3252048
3252049
3252050
3252051
3252052
3252053
3252054
3252055
3252056
3252058
3252061
3252062
3252063
3252064
37310_at
5328
7928429
A_14_P127341
A_23_P24104
A_33_P3306146
GE59641
GO:0001666
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005925
GO:0006508
GO:0006935
GO:0007165
GO:0007596
GO:0008236
GO:0009897
GO:0009986
GO:0010469
GO:0010755
GO:0010757
GO:0014909
GO:0014910
GO:0016787
GO:0030155
GO:0030335
GO:0031639
GO:0033628
GO:0035579
GO:0038195
GO:0042127
GO:0042730
GO:0043226
GO:0048870
GO:0051604
GO:0051917
GO:0051918
GO:0061041
GO:0070062
GO:0070821
GO:0097180
GO:0098637
GO:0140096
GO:1905370
GO:2000097
HMNXSV003015345
ILMN_1656057
PH_hs_0031336
TC10000475.hg
X02419_rna1_s_at
g340155_3p_s_at
g4505862_3p_a_at
Participates
as a component of
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
Other forms of this molecule
PLAU(21-431) [specific granule membrane]
PLAU(21-431) [plasma membrane]
PLAU(21-431) [tertiary granule membrane]
PLAU(21-431) [extracellular region]
PLAU(21-177) [plasma membrane]
Inferred To
Plau [plasma membrane]
(Mus musculus)
Plau [plasma membrane]
(Rattus norvegicus)
PLAU [plasma membrane]
(Bos taurus)
PLAU [plasma membrane]
(Canis familiaris)
PLAU [plasma membrane]
(Sus scrofa)
Cross References
ZINC - World Drugs
UROK_HUMAN
Guide to Pharmacology - Targets
2393
OpenTargets
ENSG00000122861
ENSEMBL
ENST00000372764
,
ENST00000446342
,
ENSP00000388474
,
ENSP00000361850
ZINC - FDA approved
UROK_HUMAN
ZINC - Substances
UROK_HUMAN
ZINC target
P00749
PRO
P00749
GlyGen
P00749
PDB
7VM5
,
1GJA
,
1SQA
,
1W14
,
4FUC
,
1VJ9
,
6L05
,
4XSK
,
7VM6
,
4ZHM
,
7DZD
,
3MWI
,
4MNY
,
5ZAG
,
4FUF
,
4ZKN
,
5WXS
,
2VIV
,
1VJA
,
4FUI
,
2VIQ
,
7ZRT
,
4FU8
,
5ZA8
,
2I9A
,
2O8T
,
6XVD
,
4JK5
,
3BT1
,
7ZRR
,
4OS1
,
4OS6
,
1C5Z
,
1C5X
,
1O5A
,
3PB1
,
4FU9
,
1OWE
,
1W11
,
6JYP
,
1KDU
,
1SQO
,
1GI9
,
5ZAE
,
3IG6
,
5HGG
,
4FUH
,
5WXQ
,
5ZAJ
,
4ZHL
,
6AG2
,
6AG9
,
4MNX
,
2NWN
,
5WXF
,
7VM7
,
2VIN
,
4GLY
,
3MHW
,
1F5L
,
1OWK
,
4FU7
,
3KHV
,
2O8U
,
2VIP
,
4K24
,
1O5B
,
4OS5
,
1EJN
,
1W12
,
3OY6
,
4X1N
,
4DW2
,
1W10
,
2R2W
,
4X1R
,
6JYQ
,
4FUE
,
4MNW
,
6L04
,
1GJB
,
5XG4
,
1W13
,
5ZAH
,
4FUG
,
5WXP
,
6AG3
,
4X0W
,
6AG7
,
7VM4
,
2VNT
,
5WXO
,
5WXT
,
1SC8
,
5Z1C
,
4FUJ
,
1OWI
,
5ZA9
,
4OS2
,
1O3P
,
1F92
,
4JK6
,
3KID
,
4ZKO
,
1C5Y
,
1O5C
,
4OS4
,
4FUB
,
1OWH
,
1SQT
,
1U6Q
,
1W0Z
,
1GJ7
,
1URK
,
1GI8
,
4X1Q
,
4MNV
,
3OX7
,
1LMW
,
4FUD
,
2I9B
,
1GI7
,
1GJC
,
3U73
,
4DVA
,
5ZC5
,
5ZAF
,
5WXR
,
3QN7
,
3M61
,
1F5K
,
1OWJ
,
3BT2
,
4ZKR
,
4H42
,
2O8W
,
2VIW
,
2VIO
,
5YC7
,
5ZA7
,
3KGP
,
1C5W
,
4OS7
,
3OY5
,
6NMB
,
1OWD
,
5YC6
,
4ZKS
,
1FV9
,
1GJ9
,
1GJD
,
1GJ8
,
4X1S
,
2FD6
,
4X1P
ZINC - Investigational
UROK_HUMAN
HPA
ENSG00000122861-PLAU
Pharos - Targets
P00749
Orphanet
PLAU
ZINC - Predictions - Purchasable
UROK_HUMAN
HMDB Protein
HMDBP02055
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05121 SERPINE1
3
SERPINE1 [extracellular region]
(R-HSA-158797)
SERPINE1 [platelet alpha granule lumen]
(R-HSA-114649)
SERPINE1 [plasma membrane]
(R-HSA-158922)
0.59
2
UniProt:P55000 SLUR1
0.59
2
UniProt:Q03405 PLAUR
7
PLAUR [endoplasmic reticulum membrane]
(R-HSA-162703)
GPI-PLAUR [endoplasmic reticulum membrane]
(R-HSA-162687)
PLAUR(306-335) [endoplasmic reticulum lumen]
(R-HSA-162707)
PLAUR(23-335) [endoplasmic reticulum membrane]
(R-HSA-162866)
GPI-PLAUR [plasma membrane]
(R-HSA-158946)
PLAUR [plasma membrane]
(R-HSA-6806165)
GPI-PLAUR [specific granule membrane]
(R-HSA-6806143)
0.564
3
UniProt:Q03405-1 PLAUR
0.558
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q9UKQ2 ADA28
0.556
3
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