Reactome | PLD1 [tertiary granule membrane]

PLD1 [tertiary granule membrane]

Stable Identifier

R-HSA-6800955

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule membrane

Synonyms

Phospholipase D1, PLD1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13393 PLD1

Gene Names

PLD1

Chain

chain:1-1074

Reference Genes

BioGPS Gene:5337 PLD1

COSMIC (genes):PLD1 PLD1

CTD Gene:5337 PLD1

dbSNP Gene:5337 PLD1

ENSEMBL:ENSG00000075651 PLD1

HGNC:9067 PLD1

KEGG Gene (Homo sapiens):5337 PLD1

Monarch:5337 PLD1

NCBI Gene:5337 PLD1

OMIM:602382 PLD1

UCSC:Q13393 PLD1

Reference Transcript

Other Identifiers

0006760609

11723545_a_at

11723546_s_at

11737322_a_at

16961551

177_at

205203_at

215723_s_at

226636_at

2705444

2705446

2705447

2705448

2705449

2705450

2705451

2705453

2705456

2705458

2705459

2705465

2705468

2705475

2705476

2705481

2705482

2705483

2705487

2705488

2705490

2705491

2705493

2705496

2705498

2705500

2705501

2705505

2705507

2705508

2705509

2705510

2705511

2705512

2705513

2705514

2705515

2705532

5337

8092134

89866_at

A_23_P155335

A_24_P123190

A_33_P3320062

GE81176

GO:0000139

GO:0002376

GO:0003674

GO:0003824

GO:0004630

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006412

GO:0006629

GO:0006654

GO:0006810

GO:0006935

GO:0007165

GO:0007264

GO:0007265

GO:0008150

GO:0008289

GO:0009056

GO:0009058

GO:0016020

GO:0016042

GO:0016192

GO:0016324

GO:0016787

GO:0022607

GO:0030139

GO:0031410

GO:0031902

GO:0032534

GO:0034641

GO:0035091

GO:0035579

GO:0040011

GO:0043167

GO:0043226

GO:0043312

GO:0045727

GO:0048017

GO:0048471

GO:0048870

GO:0070290

GO:0070821

GO:0098693

GO:0098981

HMNXSV003044645

Hs.93837.2.A1_3p_at

ILMN_1719696

PH_hs_0024328

TC03002001.hg

U38545_at

g4505872_3p_s_at

Participates

as a member of

Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)

Other forms of this molecule

PLD1 [specific granule membrane]

PLD1 [plasma membrane]

PLD1 [endoplasmic reticulum membrane]

Inferred To

SPO14 [tertiary granule membrane] (Saccharomyces cerevisiae)

pld1a [tertiary granule membrane] (Danio rerio)

pld1 [tertiary granule membrane] (Schizosaccharomyces pombe)

pld1 [tertiary granule membrane] (Xenopus tropicalis)

pldB [tertiary granule membrane] (Dictyostelium discoideum)

Pld [tertiary granule membrane] (Drosophila melanogaster)

pld-1 [tertiary granule membrane] (Caenorhabditis elegans)

PLD1 [tertiary granule membrane] (Bos taurus)

PLD1 [tertiary granule membrane] (Canis familiaris)

PLD1 [tertiary granule membrane] (Gallus gallus)

PLD1 [tertiary granule membrane] (Sus scrofa)

Pld1 [tertiary granule membrane] (Mus musculus)

Pld1 [tertiary granule membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002653.1, XP_005247590.1, XP_011511199.1, XP_005247591.1

ZINC - World Drugs

PLD1_HUMAN

Guide to Pharmacology - Targets

1433

OpenTargets

ENSG00000075651

ZINC - FDA approved

PLD1_HUMAN

ZINC - Substances

PLD1_HUMAN

ZINC target

Q13393

PRO

Q13393

PDB

6U8Z

HPA

ENSG00000075651-PLD1

GeneCards

Q13393

Ensembl

ENSG00000075651, ENST00000351298, ENST00000356327, ENSP00000348681, ENSP00000342793

Pharos - Targets

Q13393

ZINC - Predictions - Purchasable

PLD1_HUMAN

HMDB Protein

HMDBP00082

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23528 CFL1	3	p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [cytosol] (R-HSA-350751) CFL1 [extracellular region] (R-HSA-350747)	0.571	4
UniProt:Q6NXG1 ESRP1	3	ESRP1-RAF1 fusion [cytosol] (R-HSA-6802312) p-ESRP1-RAF1 fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O15287 FANCG	1	FANCG [nucleoplasm] (R-HSA-419532)	0.556	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.556	3

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