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PLD1 [tertiary granule membrane]
Stable Identifier
R-HSA-6800955
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
tertiary granule membrane
Synonyms
Phospholipase D1, PLD1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
PLD1 [tertiary granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13393 PLD1
Gene Names
PLD1
Chain
chain:1-1074
Reference Genes
BioGPS Gene:5337 PLD1
COSMIC (genes):PLD1 PLD1
CTD Gene:5337 PLD1
dbSNP Gene:5337 PLD1
ENSEMBL:ENSG00000075651.17 PLD1
HGNC:9067 PLD1
KEGG Gene (Homo sapiens):5337 PLD1
Monarch:5337 PLD1
NCBI Gene:5337 PLD1
OMIM:602382 PLD1
UCSC:Q13393 PLD1
Reference Transcript
RefSeq:XM_011512897.1 PLD1
RefSeq:NM_002662.4 PLD1
RefSeq:XM_005247533.2 PLD1
RefSeq:XM_005247534.2 PLD1
Other Identifiers
0006760609
11723545_a_at
11723546_s_at
11737322_a_at
16961551
177_PM_at
177_at
205203_PM_at
205203_at
215723_PM_s_at
215723_s_at
226636_PM_at
226636_at
2705444
2705446
2705447
2705448
2705449
2705450
2705451
2705453
2705456
2705458
2705459
2705465
2705468
2705475
2705476
2705481
2705482
2705483
2705487
2705488
2705490
2705491
2705493
2705496
2705498
2705500
2705501
2705505
2705507
2705508
2705509
2705510
2705511
2705512
2705513
2705514
2705515
2705532
5337
8092134
89866_at
A_23_P155335
A_24_P123190
A_33_P3320062
GE81176
GO:0000139
GO:0003674
GO:0003824
GO:0004630
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006629
GO:0006654
GO:0006935
GO:0007264
GO:0007265
GO:0008150
GO:0008289
GO:0012505
GO:0016020
GO:0016042
GO:0016192
GO:0016324
GO:0016787
GO:0023052
GO:0030139
GO:0031410
GO:0031902
GO:0032534
GO:0035091
GO:0035579
GO:0043226
GO:0043231
GO:0045727
GO:0048017
GO:0048471
GO:0048870
GO:0070290
GO:0070821
GO:0098693
GO:0098981
HMNXSV003044645
Hs.93837.2.A1_3p_at
ILMN_1719696
PH_hs_0024328
TC03002001.hg
U38545_at
g4505872_3p_s_at
Participates
as a member of
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
Other forms of this molecule
PLD1 [specific granule membrane]
PLD1 [plasma membrane]
PLD1 [endoplasmic reticulum membrane]
Inferred To
Homologues of PLD1 [tertiary granule membrane]
(Dictyostelium discoideum)
SPO14 [tertiary granule membrane]
(Saccharomyces cerevisiae)
pld1 [tertiary granule membrane]
(Schizosaccharomyces pombe)
pld1 [tertiary granule membrane]
(Xenopus tropicalis)
pldA [tertiary granule membrane]
(Dictyostelium discoideum)
Pld [tertiary granule membrane]
(Drosophila melanogaster)
pld-1 [tertiary granule membrane]
(Caenorhabditis elegans)
PLD1 [tertiary granule membrane]
(Bos taurus)
PLD1 [tertiary granule membrane]
(Canis familiaris)
PLD1 [tertiary granule membrane]
(Danio rerio)
PLD1 [tertiary granule membrane]
(Dictyostelium discoideum)
PLD1 [tertiary granule membrane]
(Gallus gallus)
PLD1 [tertiary granule membrane]
(Sus scrofa)
Pld1 [tertiary granule membrane]
(Mus musculus)
Pld1 [tertiary granule membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_005247590.1
,
XP_005247591.1
,
NP_002653.1
,
XP_011511199.1
ZINC - World Drugs
PLD1_HUMAN
Guide to Pharmacology - Targets
1433
OpenTargets
ENSG00000075651
ZINC - FDA approved
PLD1_HUMAN
ZINC - Substances
PLD1_HUMAN
ZINC target
Q13393
PRO
Q13393
PDB
6U8Z
GeneCards
Q13393
HPA
ENSG00000075651-PLD1
Ensembl
ENSP00000342793
,
ENSG00000075651
,
ENST00000356327
,
ENSP00000348681
,
ENST00000351298
Pharos - Targets
Q13393
ZINC - Predictions - Purchasable
PLD1_HUMAN
HMDB Protein
HMDBP00082
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.571
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
0.556
3
UniProt:O15287 FANCG
1
FANCG [nucleoplasm]
(R-HSA-419532)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
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