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About
What is Reactome ?
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Team
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
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Analysis Gene Expression
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Cytomics
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PPi [cytosol]
Stable Identifier
R-ALL-111294
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
pyrophosphate, diphosphoric acid, pyrophosphoric acid, diphosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Bos taurus)
Dephosphorylation of phospho-Cdh1 (Bos taurus)
PPi [cytosol]
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Bos taurus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)
PPi [cytosol]
Drug ADME (Bos taurus)
Azathioprine ADME (Bos taurus)
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)
PPi [cytosol]
Ribavirin ADME (Bos taurus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)
PPi [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
E1 mediated ubiquitin activation (Bos taurus)
PPi [cytosol]
Polyubiquitination of substrate (Bos taurus)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
PPi [cytosol]
Rap1 signalling (Bos taurus)
Rap1 signal termination by Rap1GAPs (Bos taurus)
PPi [cytosol]
Regulation of T cell activation by CD28 family (Bos taurus)
Co-inhibition by PD-1 (Bos taurus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
PPi [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
ISG15 antiviral mechanism (Bos taurus)
Activation of ISG15 by UBA7 E1 ligase (Bos taurus)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Bos taurus)
PPi [cytosol]
ISGylation of IRF3 (Bos taurus)
PPi [cytosol]
ISGylation of host protein filamin B (Bos taurus)
PPi [cytosol]
ISGylation of host proteins (Bos taurus)
PPi [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)
PPi [cytosol]
PKR-mediated signaling (Bos taurus)
ISGylation of PKR (Bos taurus)
PPi [cytosol]
Modulation of host responses by IFN-stimulated genes (Bos taurus)
ISGylation of DDX58 (RIG-I) (Bos taurus)
PPi [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Ethanol oxidation (Bos taurus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)
PPi [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
PPi [cytosol]
Glucuronidation (Bos taurus)
Formation of the active cofactor, UDP-glucuronate (Bos taurus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Bos taurus)
PPi [cytosol]
Methylation (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
PPi [cytosol]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Free fatty acids regulate insulin secretion (Bos taurus)
Intracellular metabolism of fatty acids regulates insulin secretion (Bos taurus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)
PPi [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Aspartate and asparagine metabolism (Bos taurus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
PPi [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
PPi [cytosol]
Sulfur amino acid metabolism (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
PPi [cytosol]
Urea cycle (Bos taurus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)
PPi [cytosol]
Metabolism of carbohydrates (Bos taurus)
Glycogen metabolism (Bos taurus)
Glycogen synthesis (Bos taurus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Bos taurus)
PPi [cytosol]
Glycosaminoglycan metabolism (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
PPi [cytosol]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Fatty acyl-CoA biosynthesis (Bos taurus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Bos taurus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)
PPi [cytosol]
Ketone body metabolism (Bos taurus)
Synthesis of Ketone Bodies (Bos taurus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
PPi [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
PPi [cytosol]
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
PPi [cytosol]
Cholesterol biosynthesis (Bos taurus)
GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Bos taurus)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Bos taurus)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)
PPi [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Synthesis of PC (Bos taurus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)
PPi [cytosol]
Synthesis of PE (Bos taurus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)
PPi [cytosol]
Synthesis of PI (Bos taurus)
PA is converted to CDP-DAG by CDS1 (Bos taurus)
PPi [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
PPi [cytosol]
Pyrimidine biosynthesis (Bos taurus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)
PPi [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
ITPA hydrolyses ITP to IMP (Bos taurus)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Bos taurus)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Bos taurus)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
PPi [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
APRT catalyzes the conversion of adenine to AMP (Bos taurus)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)
PPi [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Biotin transport and metabolism (Bos taurus)
HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Bos taurus)
PPi [cytosol]
HLCS biotinylates ACACB (Bos taurus)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Bos taurus)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Bos taurus)
Cyclisation of GTP to precursor Z (Bos taurus)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Bos taurus)
PPi [cytosol]
Nicotinate metabolism (Bos taurus)
NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Bos taurus)
PPi [cytosol]
Nicotinamide salvaging (Bos taurus)
NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)
PPi [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
FLAD1 phosphorylates FMN (Bos taurus)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
Coenzyme A biosynthesis (Bos taurus)
2xPPCS ligates PPanK with Cys (Bos taurus)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)
PPi [cytosol]
Pyrophosphate hydrolysis (Bos taurus)
LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
PPi [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Bos taurus)
PPi [cytosol]
Synthesis of GDP-mannose (Bos taurus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Bos taurus)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Bos taurus)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
Synthesis of diphthamide-EEF2 (Bos taurus)
DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)
PPi [cytosol]
Neddylation (Bos taurus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Bos taurus)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Bos taurus)
PPi [cytosol]
Protein ubiquitination (Bos taurus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Bos taurus)
UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
PPi [cytosol]
RAB geranylgeranylation (Bos taurus)
RGGT geranylgeranylates RAB proteins (Bos taurus)
PPi [cytosol]
Translation (Bos taurus)
tRNA Aminoacylation (Bos taurus)
Cytosolic tRNA aminoacylation (Bos taurus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
PPi [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
FNTA:FNTB transfers FARN to GNGT1 (Bos taurus)
PPi [cytosol]
GUCYs converts GTP to cGMP (Bos taurus)
PPi [cytosol]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
PKA-mediated phosphorylation of CREB (Bos taurus)
PKA activation (Bos taurus)
Adenylate cyclase produces cAMP (Bos taurus)
PPi [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS processing (Bos taurus)
pro-RAS proteins are farnesylated (Bos taurus)
PPi [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
Adenylate cyclase activating pathway (Bos taurus)
Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)
PPi [cytosol]
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
PKA-mediated phosphorylation of CREB (Bos taurus)
PKA activation (Bos taurus)
Adenylate cyclase produces cAMP (Bos taurus)
PPi [cytosol]
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)
PPi [cytosol]
Transport of small molecules (Bos taurus)
Miscellaneous transport and binding events (Bos taurus)
ANKH transports PPi from cytosol to extracellular region (Bos taurus)
PPi [cytosol]
Drug ADME (Caenorhabditis elegans)
Azathioprine ADME (Caenorhabditis elegans)
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)
PPi [cytosol]
Ribavirin ADME (Caenorhabditis elegans)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)
PPi [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
E1 mediated ubiquitin activation (Caenorhabditis elegans)
PPi [cytosol]
Polyubiquitination of substrate (Caenorhabditis elegans)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
PPi [cytosol]
Rap1 signalling (Caenorhabditis elegans)
Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)
PPi [cytosol]
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Interferon Signaling (Caenorhabditis elegans)
Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
ISG15 antiviral mechanism (Caenorhabditis elegans)
Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)
PPi [cytosol]
ISGylation of host protein filamin B (Caenorhabditis elegans)
PPi [cytosol]
ISGylation of host proteins (Caenorhabditis elegans)
PPi [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)
PPi [cytosol]
PKR-mediated signaling (Caenorhabditis elegans)
ISGylation of PKR (Caenorhabditis elegans)
PPi [cytosol]
Modulation of host responses by IFN-stimulated genes (Caenorhabditis elegans)
ISGylation of DDX58 (RIG-I) (Caenorhabditis elegans)
PPi [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase I - Functionalization of compounds (Caenorhabditis elegans)
Ethanol oxidation (Caenorhabditis elegans)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)
PPi [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
PPi [cytosol]
Glucuronidation (Caenorhabditis elegans)
Formation of the active cofactor, UDP-glucuronate (Caenorhabditis elegans)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)
PPi [cytosol]
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Free fatty acids regulate insulin secretion (Caenorhabditis elegans)
Intracellular metabolism of fatty acids regulates insulin secretion (Caenorhabditis elegans)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)
PPi [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Aspartate and asparagine metabolism (Caenorhabditis elegans)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
PPi [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glycogen metabolism (Caenorhabditis elegans)
Glycogen synthesis (Caenorhabditis elegans)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)
PPi [cytosol]
Glycosaminoglycan metabolism (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
PPi [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Caenorhabditis elegans)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Caenorhabditis elegans)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)
PPi [cytosol]
Ketone body metabolism (Caenorhabditis elegans)
Synthesis of Ketone Bodies (Caenorhabditis elegans)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
PPi [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Recycling of bile acids and salts (Caenorhabditis elegans)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
PPi [cytosol]
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Caenorhabditis elegans)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
PPi [cytosol]
Cholesterol biosynthesis (Caenorhabditis elegans)
FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)
PPi [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Synthesis of PC (Caenorhabditis elegans)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)
PPi [cytosol]
Synthesis of PE (Caenorhabditis elegans)
PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)
PPi [cytosol]
Synthesis of PI (Caenorhabditis elegans)
PA is converted to CDP-DAG by CDS1 (Caenorhabditis elegans)
PPi [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
PPi [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)
PPi [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
PPi [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)
PPi [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Biotin transport and metabolism (Caenorhabditis elegans)
HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)
PPi [cytosol]
HLCS biotinylates ACACB (Caenorhabditis elegans)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Caenorhabditis elegans)
Cyclisation of GTP to precursor Z (Caenorhabditis elegans)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)
PPi [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)
PPi [cytosol]
Nicotinamide salvaging (Caenorhabditis elegans)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
Coenzyme A biosynthesis (Caenorhabditis elegans)
2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)
PPi [cytosol]
Pyrophosphate hydrolysis (Caenorhabditis elegans)
LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
PPi [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
GDP-fucose biosynthesis (Caenorhabditis elegans)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Caenorhabditis elegans)
PPi [cytosol]
Synthesis of GDP-mannose (Caenorhabditis elegans)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Caenorhabditis elegans)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
Synthesis of diphthamide-EEF2 (Caenorhabditis elegans)
DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)
PPi [cytosol]
Neddylation (Caenorhabditis elegans)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Caenorhabditis elegans)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Caenorhabditis elegans)
PPi [cytosol]
Protein ubiquitination (Caenorhabditis elegans)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
PPi [cytosol]
RAB geranylgeranylation (Caenorhabditis elegans)
RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)
PPi [cytosol]
Translation (Caenorhabditis elegans)
tRNA Aminoacylation (Caenorhabditis elegans)
Cytosolic tRNA aminoacylation (Caenorhabditis elegans)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
PPi [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The phototransduction cascade (Caenorhabditis elegans)
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
FNTA:FNTB transfers FARN to GNGT1 (Caenorhabditis elegans)
PPi [cytosol]
GUCYs converts GTP to cGMP (Caenorhabditis elegans)
PPi [cytosol]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
DAG and IP3 signaling (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
PKA-mediated phosphorylation of CREB (Caenorhabditis elegans)
PKA activation (Caenorhabditis elegans)
Adenylate cyclase produces cAMP (Caenorhabditis elegans)
PPi [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS processing (Caenorhabditis elegans)
pro-RAS proteins are farnesylated (Caenorhabditis elegans)
PPi [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
Adenylate cyclase activating pathway (Caenorhabditis elegans)
Adenylate cyclase converts ATP into cyclic AMP (Caenorhabditis elegans)
PPi [cytosol]
PLC beta mediated events (Caenorhabditis elegans)
Ca-dependent events (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
PKA-mediated phosphorylation of CREB (Caenorhabditis elegans)
PKA activation (Caenorhabditis elegans)
Adenylate cyclase produces cAMP (Caenorhabditis elegans)
PPi [cytosol]
Signaling by Hedgehog (Caenorhabditis elegans)
Hedgehog 'off' state (Caenorhabditis elegans)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)
PPi [cytosol]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Canis familiaris)
Dephosphorylation of phospho-Cdh1 (Canis familiaris)
PPi [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
Nuclear events mediated by NFE2L2 (Canis familiaris)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Canis familiaris)
SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)
PPi [cytosol]
Drug ADME (Canis familiaris)
Azathioprine ADME (Canis familiaris)
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)
PPi [cytosol]
Ribavirin ADME (Canis familiaris)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)
PPi [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
E1 mediated ubiquitin activation (Canis familiaris)
PPi [cytosol]
Polyubiquitination of substrate (Canis familiaris)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
PPi [cytosol]
Rap1 signalling (Canis familiaris)
Rap1 signal termination by Rap1GAPs (Canis familiaris)
PPi [cytosol]
Regulation of T cell activation by CD28 family (Canis familiaris)
Co-inhibition by PD-1 (Canis familiaris)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
PPi [cytosol]
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
ISG15 antiviral mechanism (Canis familiaris)
Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)
PPi [cytosol]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)
PPi [cytosol]
TRAF6 oligomer autoubiquitinates (Canis familiaris)
PPi [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
Auto-ubiquitination of TRAF6 (Canis familiaris)
PPi [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Ethanol oxidation (Canis familiaris)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)
PPi [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
Transport and synthesis of PAPS (Canis familiaris)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
PPi [cytosol]
Glucuronidation (Canis familiaris)
Formation of the active cofactor, UDP-glucuronate (Canis familiaris)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)
PPi [cytosol]
Methylation (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
PPi [cytosol]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Free fatty acids regulate insulin secretion (Canis familiaris)
Intracellular metabolism of fatty acids regulates insulin secretion (Canis familiaris)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)
PPi [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Aspartate and asparagine metabolism (Canis familiaris)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
PPi [cytosol]
Selenoamino acid metabolism (Canis familiaris)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
PPi [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
PPi [cytosol]
Urea cycle (Canis familiaris)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)
PPi [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Glycogen metabolism (Canis familiaris)
Glycogen synthesis (Canis familiaris)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)
PPi [cytosol]
Glycosaminoglycan metabolism (Canis familiaris)
Transport and synthesis of PAPS (Canis familiaris)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
PPi [cytosol]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Fatty acyl-CoA biosynthesis (Canis familiaris)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Canis familiaris)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)
PPi [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Recycling of bile acids and salts (Canis familiaris)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
PPi [cytosol]
Synthesis of bile acids and bile salts (Canis familiaris)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
PPi [cytosol]
Cholesterol biosynthesis (Canis familiaris)
FDPS dimer transfers IPPP to DMAPP (Canis familiaris)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Canis familiaris)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Canis familiaris)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Canis familiaris)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Canis familiaris)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)
PPi [cytosol]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Synthesis of PC (Canis familiaris)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)
PPi [cytosol]
Synthesis of PE (Canis familiaris)
PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)
PPi [cytosol]
Synthesis of PI (Canis familiaris)
PA is converted to CDP-DAG by CDS1 (Canis familiaris)
PPi [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
PPi [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)
PPi [cytosol]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
ITPA hydrolyses ITP to IMP (Canis familiaris)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Canis familiaris)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Canis familiaris)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
PPi [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
APRT catalyzes the conversion of adenine to AMP (Canis familiaris)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)
PPi [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Biotin transport and metabolism (Canis familiaris)
HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Canis familiaris)
PPi [cytosol]
HLCS biotinylates ACACB (Canis familiaris)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Canis familiaris)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Canis familiaris)
Cyclisation of GTP to precursor Z (Canis familiaris)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Canis familiaris)
PPi [cytosol]
Nicotinate metabolism (Canis familiaris)
NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Canis familiaris)
PPi [cytosol]
Nicotinamide salvaging (Canis familiaris)
NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)
PPi [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
FLAD1 phosphorylates FMN (Canis familiaris)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Canis familiaris)
Coenzyme A biosynthesis (Canis familiaris)
2xPPCS ligates PPanK with Cys (Canis familiaris)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)
PPi [cytosol]
Pyrophosphate hydrolysis (Canis familiaris)
LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
PPi [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
GDP-fucose biosynthesis (Canis familiaris)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Canis familiaris)
PPi [cytosol]
Synthesis of GDP-mannose (Canis familiaris)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Canis familiaris)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Canis familiaris)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Canis familiaris)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Synthesis of diphthamide-EEF2 (Canis familiaris)
DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)
PPi [cytosol]
Neddylation (Canis familiaris)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)
PPi [cytosol]
Protein ubiquitination (Canis familiaris)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Canis familiaris)
UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
PPi [cytosol]
RAB geranylgeranylation (Canis familiaris)
RGGT geranylgeranylates RAB proteins (Canis familiaris)
PPi [cytosol]
Translation (Canis familiaris)
tRNA Aminoacylation (Canis familiaris)
Cytosolic tRNA aminoacylation (Canis familiaris)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
PPi [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The phototransduction cascade (Canis familiaris)
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
GUCYs converts GTP to cGMP (Canis familiaris)
PPi [cytosol]
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
DAG and IP3 signaling (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
PPi [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
Adenylate cyclase activating pathway (Canis familiaris)
Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)
PPi [cytosol]
PLC beta mediated events (Canis familiaris)
Ca-dependent events (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
PPi [cytosol]
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'off' state (Canis familiaris)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)
PPi [cytosol]
Transport of small molecules (Canis familiaris)
Miscellaneous transport and binding events (Canis familiaris)
ANKH transports PPi from cytosol to extracellular region (Canis familiaris)
PPi [cytosol]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
Regulation of mitotic cell cycle (Danio rerio)
APC/C-mediated degradation of cell cycle proteins (Danio rerio)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Danio rerio)
Dephosphorylation of phospho-Cdh1 (Danio rerio)
PPi [cytosol]
Drug ADME (Danio rerio)
Azathioprine ADME (Danio rerio)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)
PPi [cytosol]
Ribavirin ADME (Danio rerio)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)
PPi [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Class I MHC mediated antigen processing & presentation (Danio rerio)
Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
E1 mediated ubiquitin activation (Danio rerio)
PPi [cytosol]
Polyubiquitination of substrate (Danio rerio)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
PPi [cytosol]
Rap1 signalling (Danio rerio)
Rap1 signal termination by Rap1GAPs (Danio rerio)
PPi [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase II - Conjugation of compounds (Danio rerio)
Cytosolic sulfonation of small molecules (Danio rerio)
Transport and synthesis of PAPS (Danio rerio)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)
PPi [cytosol]
Methylation (Danio rerio)
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)
PPi [cytosol]
Integration of energy metabolism (Danio rerio)
Regulation of insulin secretion (Danio rerio)
Free fatty acids regulate insulin secretion (Danio rerio)
Intracellular metabolism of fatty acids regulates insulin secretion (Danio rerio)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Danio rerio)
PPi [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Selenoamino acid metabolism (Danio rerio)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Danio rerio)
SeMet is converted to AdoSeMet by MAT (Danio rerio)
PPi [cytosol]
Sulfur amino acid metabolism (Danio rerio)
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
PPi [cytosol]
Metabolism of carbohydrates (Danio rerio)
Glycosaminoglycan metabolism (Danio rerio)
Transport and synthesis of PAPS (Danio rerio)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)
PPi [cytosol]
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Fatty acyl-CoA biosynthesis (Danio rerio)
Synthesis of very long-chain fatty acyl-CoAs (Danio rerio)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)
PPi [cytosol]
Ketone body metabolism (Danio rerio)
Synthesis of Ketone Bodies (Danio rerio)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)
PPi [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Recycling of bile acids and salts (Danio rerio)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
PPi [cytosol]
Synthesis of bile acids and bile salts (Danio rerio)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Danio rerio)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Danio rerio)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
PPi [cytosol]
Cholesterol biosynthesis (Danio rerio)
FDPS dimer transfers IPPP to DMAPP (Danio rerio)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Danio rerio)
PPi [cytosol]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Synthesis of PC (Danio rerio)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)
PPi [cytosol]
Synthesis of PE (Danio rerio)
PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)
PPi [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
PPi [cytosol]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
ITPA hydrolyses ITP to IMP (Danio rerio)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Danio rerio)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Danio rerio)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
PPi [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
APRT catalyzes the conversion of adenine to AMP (Danio rerio)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)
PPi [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Nicotinate metabolism (Danio rerio)
NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)
PPi [cytosol]
Nicotinamide salvaging (Danio rerio)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Danio rerio)
FLAD1 phosphorylates FMN (Danio rerio)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Danio rerio)
Coenzyme A biosynthesis (Danio rerio)
2xPPCS ligates PPanK with Cys (Danio rerio)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)
PPi [cytosol]
Pyrophosphate hydrolysis (Danio rerio)
LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
PPi [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Synthesis of GDP-mannose (Danio rerio)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Danio rerio)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Danio rerio)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Danio rerio)
PPi [cytosol]
Neddylation (Danio rerio)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Danio rerio)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Danio rerio)
PPi [cytosol]
Protein ubiquitination (Danio rerio)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Danio rerio)
UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
PPi [cytosol]
RAB geranylgeranylation (Danio rerio)
RGGT geranylgeranylates RAB proteins (Danio rerio)
PPi [cytosol]
Translation (Danio rerio)
tRNA Aminoacylation (Danio rerio)
Cytosolic tRNA aminoacylation (Danio rerio)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
PPi [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
The phototransduction cascade (Danio rerio)
Inactivation, recovery and regulation of the phototransduction cascade (Danio rerio)
FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)
PPi [cytosol]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
DAG and IP3 signaling (Danio rerio)
CaM pathway (Danio rerio)
Calmodulin induced events (Danio rerio)
PKA-mediated phosphorylation of CREB (Danio rerio)
PKA activation (Danio rerio)
Adenylate cyclase produces cAMP (Danio rerio)
PPi [cytosol]
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS processing (Danio rerio)
pro-RAS proteins are farnesylated (Danio rerio)
PPi [cytosol]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Opioid Signalling (Danio rerio)
G-protein mediated events (Danio rerio)
Adenylate cyclase activating pathway (Danio rerio)
Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)
PPi [cytosol]
PLC beta mediated events (Danio rerio)
Ca-dependent events (Danio rerio)
CaM pathway (Danio rerio)
Calmodulin induced events (Danio rerio)
PKA-mediated phosphorylation of CREB (Danio rerio)
PKA activation (Danio rerio)
Adenylate cyclase produces cAMP (Danio rerio)
PPi [cytosol]
Signaling by Hedgehog (Danio rerio)
Hedgehog 'off' state (Danio rerio)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Danio rerio)
PPi [cytosol]
Transport of small molecules (Danio rerio)
Miscellaneous transport and binding events (Danio rerio)
ANKH transports PPi from cytosol to extracellular region (Danio rerio)
PPi [cytosol]
Drug ADME (Dictyostelium discoideum)
Azathioprine ADME (Dictyostelium discoideum)
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)
PPi [cytosol]
Ribavirin ADME (Dictyostelium discoideum)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)
PPi [cytosol]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Class I MHC mediated antigen processing & presentation (Dictyostelium discoideum)
Antigen processing: Ubiquitination & Proteasome degradation (Dictyostelium discoideum)
E1 mediated ubiquitin activation (Dictyostelium discoideum)
PPi [cytosol]
Polyubiquitination of substrate (Dictyostelium discoideum)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)
PPi [cytosol]
Rap1 signalling (Dictyostelium discoideum)
Rap1 signal termination by Rap1GAPs (Dictyostelium discoideum)
PPi [cytosol]
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Interferon Signaling (Dictyostelium discoideum)
Antiviral mechanism by IFN-stimulated genes (Dictyostelium discoideum)
ISG15 antiviral mechanism (Dictyostelium discoideum)
Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Dictyostelium discoideum)
PPi [cytosol]
ISGylation of host protein filamin B (Dictyostelium discoideum)
PPi [cytosol]
ISGylation of host proteins (Dictyostelium discoideum)
PPi [cytosol]
Modulation of host responses by IFN-stimulated genes (Dictyostelium discoideum)
ISGylation of DDX58 (RIG-I) (Dictyostelium discoideum)
PPi [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase I - Functionalization of compounds (Dictyostelium discoideum)
Ethanol oxidation (Dictyostelium discoideum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)
PPi [cytosol]
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Glucuronidation (Dictyostelium discoideum)
Formation of the active cofactor, UDP-glucuronate (Dictyostelium discoideum)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)
PPi [cytosol]
Methylation (Dictyostelium discoideum)
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)
PPi [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Aspartate and asparagine metabolism (Dictyostelium discoideum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
PPi [cytosol]
Selenoamino acid metabolism (Dictyostelium discoideum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Dictyostelium discoideum)
SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
PPi [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
PPi [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Glycogen metabolism (Dictyostelium discoideum)
Glycogen synthesis (Dictyostelium discoideum)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)
PPi [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Fatty acid metabolism (Dictyostelium discoideum)
Fatty acyl-CoA biosynthesis (Dictyostelium discoideum)
Synthesis of very long-chain fatty acyl-CoAs (Dictyostelium discoideum)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)
PPi [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Cholesterol biosynthesis (Dictyostelium discoideum)
FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)
PPi [cytosol]
Phospholipid metabolism (Dictyostelium discoideum)
Glycerophospholipid biosynthesis (Dictyostelium discoideum)
Synthesis of PC (Dictyostelium discoideum)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)
PPi [cytosol]
Synthesis of PE (Dictyostelium discoideum)
PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)
PPi [cytosol]
Synthesis of PI (Dictyostelium discoideum)
PA is converted to CDP-DAG by CDS1 (Dictyostelium discoideum)
PPi [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleotide biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
PPi [cytosol]
Pyrimidine biosynthesis (Dictyostelium discoideum)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)
PPi [cytosol]
Nucleotide catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
PPi [cytosol]
Nucleotide salvage (Dictyostelium discoideum)
Purine salvage (Dictyostelium discoideum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)
PPi [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Biotin transport and metabolism (Dictyostelium discoideum)
HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)
PPi [cytosol]
HLCS biotinylates ACACB (Dictyostelium discoideum)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Dictyostelium discoideum)
Cyclisation of GTP to precursor Z (Dictyostelium discoideum)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)
PPi [cytosol]
Nicotinate metabolism (Dictyostelium discoideum)
NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)
PPi [cytosol]
Nicotinamide salvaging (Dictyostelium discoideum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Dictyostelium discoideum)
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Dictyostelium discoideum)
Coenzyme A biosynthesis (Dictyostelium discoideum)
2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)
PPi [cytosol]
Pyrophosphate hydrolysis (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
PPi [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
GDP-fucose biosynthesis (Dictyostelium discoideum)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)
PPi [cytosol]
Synthesis of GDP-mannose (Dictyostelium discoideum)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Dictyostelium discoideum)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Dictyostelium discoideum)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
Synthesis of diphthamide-EEF2 (Dictyostelium discoideum)
DPH6 ligates ammonium to diphthine-EEF2 (Dictyostelium discoideum)
PPi [cytosol]
Neddylation (Dictyostelium discoideum)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Dictyostelium discoideum)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)
PPi [cytosol]
Protein ubiquitination (Dictyostelium discoideum)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Dictyostelium discoideum)
UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)
PPi [cytosol]
RAB geranylgeranylation (Dictyostelium discoideum)
RGGT geranylgeranylates RAB proteins (Dictyostelium discoideum)
PPi [cytosol]
Translation (Dictyostelium discoideum)
tRNA Aminoacylation (Dictyostelium discoideum)
Cytosolic tRNA aminoacylation (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
PPi [cytosol]
Sensory Perception (Dictyostelium discoideum)
Visual phototransduction (Dictyostelium discoideum)
The phototransduction cascade (Dictyostelium discoideum)
Inactivation, recovery and regulation of the phototransduction cascade (Dictyostelium discoideum)
GUCYs converts GTP to cGMP (Dictyostelium discoideum)
PPi [cytosol]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
DAG and IP3 signaling (Dictyostelium discoideum)
CaM pathway (Dictyostelium discoideum)
Calmodulin induced events (Dictyostelium discoideum)
PKA-mediated phosphorylation of CREB (Dictyostelium discoideum)
PKA activation (Dictyostelium discoideum)
Adenylate cyclase produces cAMP (Dictyostelium discoideum)
PPi [cytosol]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Opioid Signalling (Dictyostelium discoideum)
G-protein mediated events (Dictyostelium discoideum)
Adenylate cyclase activating pathway (Dictyostelium discoideum)
Adenylate cyclase converts ATP into cyclic AMP (Dictyostelium discoideum)
PPi [cytosol]
PLC beta mediated events (Dictyostelium discoideum)
Ca-dependent events (Dictyostelium discoideum)
CaM pathway (Dictyostelium discoideum)
Calmodulin induced events (Dictyostelium discoideum)
PKA-mediated phosphorylation of CREB (Dictyostelium discoideum)
PKA activation (Dictyostelium discoideum)
Adenylate cyclase produces cAMP (Dictyostelium discoideum)
PPi [cytosol]
Signaling by Hedgehog (Dictyostelium discoideum)
Hedgehog 'off' state (Dictyostelium discoideum)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)
PPi [cytosol]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Drosophila melanogaster)
Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)
PPi [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Drosophila melanogaster)
SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)
PPi [cytosol]
Drug ADME (Drosophila melanogaster)
Azathioprine ADME (Drosophila melanogaster)
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
PPi [cytosol]
Ribavirin ADME (Drosophila melanogaster)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)
PPi [cytosol]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
E1 mediated ubiquitin activation (Drosophila melanogaster)
PPi [cytosol]
Polyubiquitination of substrate (Drosophila melanogaster)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
PPi [cytosol]
Rap1 signalling (Drosophila melanogaster)
Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)
PPi [cytosol]
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
ISG15 antiviral mechanism (Drosophila melanogaster)
Activation of ISG15 by UBA7 E1 ligase (Drosophila melanogaster)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Drosophila melanogaster)
PPi [cytosol]
ISGylation of host protein filamin B (Drosophila melanogaster)
PPi [cytosol]
ISGylation of host proteins (Drosophila melanogaster)
PPi [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Drosophila melanogaster)
PPi [cytosol]
PKR-mediated signaling (Drosophila melanogaster)
ISGylation of PKR (Drosophila melanogaster)
PPi [cytosol]
Metabolism (Drosophila melanogaster)
Biological oxidations (Drosophila melanogaster)
Phase I - Functionalization of compounds (Drosophila melanogaster)
Ethanol oxidation (Drosophila melanogaster)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Drosophila melanogaster)
PPi [cytosol]
Phase II - Conjugation of compounds (Drosophila melanogaster)
Cytosolic sulfonation of small molecules (Drosophila melanogaster)
Transport and synthesis of PAPS (Drosophila melanogaster)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)
PPi [cytosol]
Glucuronidation (Drosophila melanogaster)
Formation of the active cofactor, UDP-glucuronate (Drosophila melanogaster)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Drosophila melanogaster)
PPi [cytosol]
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Intracellular metabolism of fatty acids regulates insulin secretion (Drosophila melanogaster)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)
PPi [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Glycogen metabolism (Drosophila melanogaster)
Glycogen synthesis (Drosophila melanogaster)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Drosophila melanogaster)
PPi [cytosol]
Glycosaminoglycan metabolism (Drosophila melanogaster)
Transport and synthesis of PAPS (Drosophila melanogaster)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)
PPi [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Fatty acid metabolism (Drosophila melanogaster)
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Drosophila melanogaster)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Drosophila melanogaster)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)
PPi [cytosol]
Metabolism of steroids (Drosophila melanogaster)
Bile acid and bile salt metabolism (Drosophila melanogaster)
Recycling of bile acids and salts (Drosophila melanogaster)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
PPi [cytosol]
Synthesis of bile acids and bile salts (Drosophila melanogaster)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Drosophila melanogaster)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Drosophila melanogaster)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
PPi [cytosol]
Cholesterol biosynthesis (Drosophila melanogaster)
FDPS dimer transfers IPPP to DMAPP (Drosophila melanogaster)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Drosophila melanogaster)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Drosophila melanogaster)
PPi [cytosol]
Phospholipid metabolism (Drosophila melanogaster)
Glycerophospholipid biosynthesis (Drosophila melanogaster)
Synthesis of PC (Drosophila melanogaster)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)
PPi [cytosol]
Synthesis of PE (Drosophila melanogaster)
PETA and CTP are condensed to CDP-ETA by PCY2 (Drosophila melanogaster)
PPi [cytosol]
Synthesis of PI (Drosophila melanogaster)
PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)
PPi [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
PPi [cytosol]
Pyrimidine biosynthesis (Drosophila melanogaster)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)
PPi [cytosol]
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
PPi [cytosol]
Nucleotide salvage (Drosophila melanogaster)
Purine salvage (Drosophila melanogaster)
APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)
PPi [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Biotin transport and metabolism (Drosophila melanogaster)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Drosophila melanogaster)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)
PPi [cytosol]
HLCS biotinylates ACACB (Drosophila melanogaster)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Drosophila melanogaster)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Drosophila melanogaster)
Cyclisation of GTP to precursor Z (Drosophila melanogaster)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)
PPi [cytosol]
Nicotinate metabolism (Drosophila melanogaster)
NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)
PPi [cytosol]
Nicotinamide salvaging (Drosophila melanogaster)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Drosophila melanogaster)
Coenzyme A biosynthesis (Drosophila melanogaster)
2xPPCS ligates PPanK with Cys (Drosophila melanogaster)
PPi [cytosol]
Pyrophosphate hydrolysis (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
PPi [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)
Synthesis of substrates in N-glycan biosythesis (Drosophila melanogaster)
Synthesis of GDP-mannose (Drosophila melanogaster)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Drosophila melanogaster)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Drosophila melanogaster)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
Synthesis of diphthamide-EEF2 (Drosophila melanogaster)
DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)
PPi [cytosol]
Neddylation (Drosophila melanogaster)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Drosophila melanogaster)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)
PPi [cytosol]
Protein ubiquitination (Drosophila melanogaster)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Drosophila melanogaster)
UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
PPi [cytosol]
RAB geranylgeranylation (Drosophila melanogaster)
RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)
PPi [cytosol]
Translation (Drosophila melanogaster)
tRNA Aminoacylation (Drosophila melanogaster)
Cytosolic tRNA aminoacylation (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
PPi [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
The phototransduction cascade (Drosophila melanogaster)
Inactivation, recovery and regulation of the phototransduction cascade (Drosophila melanogaster)
FNTA:FNTB transfers FARN to GNGT1 (Drosophila melanogaster)
PPi [cytosol]
GUCYs converts GTP to cGMP (Drosophila melanogaster)
PPi [cytosol]
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
DAG and IP3 signaling (Drosophila melanogaster)
CaM pathway (Drosophila melanogaster)
Calmodulin induced events (Drosophila melanogaster)
PKA-mediated phosphorylation of CREB (Drosophila melanogaster)
PKA activation (Drosophila melanogaster)
Adenylate cyclase produces cAMP (Drosophila melanogaster)
PPi [cytosol]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS processing (Drosophila melanogaster)
pro-RAS proteins are farnesylated (Drosophila melanogaster)
PPi [cytosol]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Opioid Signalling (Drosophila melanogaster)
G-protein mediated events (Drosophila melanogaster)
Adenylate cyclase activating pathway (Drosophila melanogaster)
Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)
PPi [cytosol]
PLC beta mediated events (Drosophila melanogaster)
Ca-dependent events (Drosophila melanogaster)
CaM pathway (Drosophila melanogaster)
Calmodulin induced events (Drosophila melanogaster)
PKA-mediated phosphorylation of CREB (Drosophila melanogaster)
PKA activation (Drosophila melanogaster)
Adenylate cyclase produces cAMP (Drosophila melanogaster)
PPi [cytosol]
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)
PPi [cytosol]
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
Regulation of mitotic cell cycle (Gallus gallus)
APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Gallus gallus)
Dephosphorylation of phospho-Cdh1 (Gallus gallus)
PPi [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
KEAP1-NFE2L2 pathway (Gallus gallus)
Nuclear events mediated by NFE2L2 (Gallus gallus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Gallus gallus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)
PPi [cytosol]
Drug ADME (Gallus gallus)
Azathioprine ADME (Gallus gallus)
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)
PPi [cytosol]
Ribavirin ADME (Gallus gallus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)
PPi [cytosol]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
E1 mediated ubiquitin activation (Gallus gallus)
PPi [cytosol]
Polyubiquitination of substrate (Gallus gallus)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
PPi [cytosol]
Rap1 signalling (Gallus gallus)
Rap1 signal termination by Rap1GAPs (Gallus gallus)
PPi [cytosol]
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-inhibition by PD-1 (Gallus gallus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)
PPi [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
Ethanol oxidation (Gallus gallus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Gallus gallus)
PPi [cytosol]
Phase II - Conjugation of compounds (Gallus gallus)
Cytosolic sulfonation of small molecules (Gallus gallus)
Transport and synthesis of PAPS (Gallus gallus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Gallus gallus)
PPi [cytosol]
Glucuronidation (Gallus gallus)
Formation of the active cofactor, UDP-glucuronate (Gallus gallus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Gallus gallus)
PPi [cytosol]
Methylation (Gallus gallus)
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Gallus gallus)
PPi [cytosol]
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Free fatty acids regulate insulin secretion (Gallus gallus)
Intracellular metabolism of fatty acids regulates insulin secretion (Gallus gallus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Gallus gallus)
PPi [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Aspartate and asparagine metabolism (Gallus gallus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Gallus gallus)
PPi [cytosol]
Selenoamino acid metabolism (Gallus gallus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Gallus gallus)
SeMet is converted to AdoSeMet by MAT (Gallus gallus)
PPi [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
PPi [cytosol]
Urea cycle (Gallus gallus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Gallus gallus)
PPi [cytosol]
Metabolism of carbohydrates (Gallus gallus)
Glycogen metabolism (Gallus gallus)
Glycogen synthesis (Gallus gallus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Gallus gallus)
PPi [cytosol]
Glycosaminoglycan metabolism (Gallus gallus)
Transport and synthesis of PAPS (Gallus gallus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Gallus gallus)
PPi [cytosol]
Metabolism of lipids (Gallus gallus)
Fatty acid metabolism (Gallus gallus)
Fatty acyl-CoA biosynthesis (Gallus gallus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Gallus gallus)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Gallus gallus)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Gallus gallus)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Gallus gallus)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Gallus gallus)
PPi [cytosol]
Ketone body metabolism (Gallus gallus)
Synthesis of Ketone Bodies (Gallus gallus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Gallus gallus)
PPi [cytosol]
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Recycling of bile acids and salts (Gallus gallus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
PPi [cytosol]
Synthesis of bile acids and bile salts (Gallus gallus)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Gallus gallus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Gallus gallus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
PPi [cytosol]
Cholesterol biosynthesis (Gallus gallus)
FDPS dimer transfers IPPP to DMAPP (Gallus gallus)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Gallus gallus)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Gallus gallus)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Gallus gallus)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Gallus gallus)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Gallus gallus)
PPi [cytosol]
Phospholipid metabolism (Gallus gallus)
Glycerophospholipid biosynthesis (Gallus gallus)
Synthesis of PC (Gallus gallus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Gallus gallus)
PPi [cytosol]
Synthesis of PE (Gallus gallus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Gallus gallus)
PPi [cytosol]
Synthesis of PI (Gallus gallus)
PA is converted to CDP-DAG by CDS1 (Gallus gallus)
PPi [cytosol]
Metabolism of nucleotides (Gallus gallus)
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
PPi [cytosol]
Pyrimidine biosynthesis (Gallus gallus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Gallus gallus)
PPi [cytosol]
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
ITPA hydrolyses ITP to IMP (Gallus gallus)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Gallus gallus)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Gallus gallus)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Gallus gallus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
PPi [cytosol]
Nucleotide salvage (Gallus gallus)
Purine salvage (Gallus gallus)
APRT catalyzes the conversion of adenine to AMP (Gallus gallus)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Gallus gallus)
PPi [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Biotin transport and metabolism (Gallus gallus)
HLCS biotinylates 6x(PCCA:PCCB) (Gallus gallus)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Gallus gallus)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Gallus gallus)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Gallus gallus)
Cyclisation of GTP to precursor Z (Gallus gallus)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Gallus gallus)
PPi [cytosol]
Nicotinate metabolism (Gallus gallus)
NADSYN1 hexamer amidates NAAD to NAD+ (Gallus gallus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Gallus gallus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Gallus gallus)
PPi [cytosol]
Nicotinamide salvaging (Gallus gallus)
NAMPT transfers PRIB to NAM to form NAMN (Gallus gallus)
PPi [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Gallus gallus)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Gallus gallus)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
FLAD1 phosphorylates FMN (Gallus gallus)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Gallus gallus)
Coenzyme A biosynthesis (Gallus gallus)
2xPPCS ligates PPanK with Cys (Gallus gallus)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Gallus gallus)
PPi [cytosol]
Pyrophosphate hydrolysis (Gallus gallus)
LHPP:Mg2+ dimer hydrolyses PPi (Gallus gallus)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
PPi [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
GDP-fucose biosynthesis (Gallus gallus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)
PPi [cytosol]
Synthesis of GDP-mannose (Gallus gallus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Gallus gallus)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Gallus gallus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
Synthesis of diphthamide-EEF2 (Gallus gallus)
DPH6 ligates ammonium to diphthine-EEF2 (Gallus gallus)
PPi [cytosol]
Neddylation (Gallus gallus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Gallus gallus)
PPi [cytosol]
Protein ubiquitination (Gallus gallus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Gallus gallus)
UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)
PPi [cytosol]
Translation (Gallus gallus)
tRNA Aminoacylation (Gallus gallus)
Cytosolic tRNA aminoacylation (Gallus gallus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
PPi [cytosol]
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
DAG and IP3 signaling (Gallus gallus)
CaM pathway (Gallus gallus)
Calmodulin induced events (Gallus gallus)
PKA-mediated phosphorylation of CREB (Gallus gallus)
PKA activation (Gallus gallus)
Adenylate cyclase produces cAMP (Gallus gallus)
PPi [cytosol]
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS processing (Gallus gallus)
pro-RAS proteins are farnesylated (Gallus gallus)
PPi [cytosol]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Opioid Signalling (Gallus gallus)
G-protein mediated events (Gallus gallus)
Adenylate cyclase activating pathway (Gallus gallus)
Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)
PPi [cytosol]
PLC beta mediated events (Gallus gallus)
Ca-dependent events (Gallus gallus)
CaM pathway (Gallus gallus)
Calmodulin induced events (Gallus gallus)
PKA-mediated phosphorylation of CREB (Gallus gallus)
PKA activation (Gallus gallus)
Adenylate cyclase produces cAMP (Gallus gallus)
PPi [cytosol]
Signaling by Hedgehog (Gallus gallus)
Hedgehog 'off' state (Gallus gallus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)
PPi [cytosol]
Transport of small molecules (Gallus gallus)
Miscellaneous transport and binding events (Gallus gallus)
ANKH transports PPi from cytosol to extracellular region (Gallus gallus)
PPi [cytosol]
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
Dephosphorylation of phospho-Cdh1 (Homo sapiens)
PPi [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
PPi [cytosol]
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)
PPi [cytosol]
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Z-decay: degradation of maternal mRNAs by zygotically expressed factors (Homo sapiens)
TUT4,TUT7 oligouridylate mRNA (Homo sapiens)
PPi [cytosol]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Antimicrobial action and antimicrobial resistance in Mtb (Homo sapiens)
Defective RpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)
PPi [cytosol]
RNAP transcribes Mtb RNA polyanion (Homo sapiens)
PPi [cytosol]
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)
PPi [cytosol]
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
PPi [cytosol]
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Adenylate cyclase produces cAMP (Homo sapiens)
PPi [cytosol]
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Reverse Transcription of HIV RNA (Homo sapiens)
Minus-strand DNA synthesis (Homo sapiens)
Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)
PPi [cytosol]
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
ISGylation of BECN1 (Homo sapiens)
PPi [cytosol]
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Respiratory syncytial virus genome transcription (Homo sapiens)
L protein acts as a cap N7 methyltransferase to modify RSV mRNAs (Homo sapiens)
PPi [cytosol]
Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs (Homo sapiens)
PPi [cytosol]
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-1 genome (Homo sapiens)
Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) (Homo sapiens)
PPi [cytosol]
RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
PPi [cytosol]
RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)
PPi [cytosol]
nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
PPi [cytosol]
nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)
PPi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
PPi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
PPi [cytosol]
nsp8 generates RNA primers (Homo sapiens)
PPi [cytosol]
Transcription of SARS-CoV-1 sgRNAs (Homo sapiens)
Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand) (Homo sapiens)
PPi [cytosol]
Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)
PPi [cytosol]
Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)
PPi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
PPi [cytosol]
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
SARS-CoV-2 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-2 genome (Homo sapiens)
Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)
PPi [cytosol]
RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
PPi [cytosol]
RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)
PPi [cytosol]
nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
PPi [cytosol]
nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)
PPi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
PPi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
PPi [cytosol]
nsp8 generates RNA primers (Homo sapiens)
PPi [cytosol]
Transcription of SARS-CoV-2 sgRNAs (Homo sapiens)
Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)
PPi [cytosol]
Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)
PPi [cytosol]
Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)
PPi [cytosol]
nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)
PPi [cytosol]
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) (Homo sapiens)
nsp12 guanylates nsp7 (Homo sapiens)
PPi [cytosol]
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)
PPi [cytosol]
Ribavirin ADME (Homo sapiens)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)
PPi [cytosol]
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)
PPi [cytosol]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
E1 mediated ubiquitin activation (Homo sapiens)
PPi [cytosol]
Polyubiquitination of substrate (Homo sapiens)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
PPi [cytosol]
Rap1 signalling (Homo sapiens)
Rap1 signal termination by Rap1GAPs (Homo sapiens)
PPi [cytosol]
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PPi [cytosol]
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Homo sapiens)
PPi [cytosol]
ISGylation of IRF3 (Homo sapiens)
PPi [cytosol]
ISGylation of host protein filamin B (Homo sapiens)
PPi [cytosol]
ISGylation of host proteins (Homo sapiens)
PPi [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
PPi [cytosol]
ISGylation of viral protein NS1 (Homo sapiens)
PPi [cytosol]
OAS antiviral response (Homo sapiens)
OAS1 produces oligoadenylates (Homo sapiens)
PPi [cytosol]
OAS2 produces oligoadenylates (Homo sapiens)
PPi [cytosol]
OAS3 produces oligoadenylates (Homo sapiens)
PPi [cytosol]
PKR-mediated signaling (Homo sapiens)
ISGylation of PKR (Homo sapiens)
PPi [cytosol]
Modulation of host responses by IFN-stimulated genes (Homo sapiens)
ISGylation of DDX58 (RIG-I) (Homo sapiens)
PPi [cytosol]
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)
PPi [cytosol]
TRAF6 oligomer autoubiquitinates (Homo sapiens)
PPi [cytosol]
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
cGAS produces cyclic GMP-AMP (Homo sapiens)
PPi [cytosol]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Auto-ubiquitination of TRAF6 (Homo sapiens)
PPi [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Ethanol oxidation (Homo sapiens)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Homo sapiens)
PPi [cytosol]
Phase II - Conjugation of compounds (Homo sapiens)
Cytosolic sulfonation of small molecules (Homo sapiens)
Transport and synthesis of PAPS (Homo sapiens)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)
PPi [cytosol]
Glucuronidation (Homo sapiens)
Formation of the active cofactor, UDP-glucuronate (Homo sapiens)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)
PPi [cytosol]
Methylation (Homo sapiens)
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)
PPi [cytosol]
Integration of energy metabolism (Homo sapiens)
Glucagon signaling in metabolic regulation (Homo sapiens)
PKA activation in glucagon signalling (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
PPi [cytosol]
Regulation of insulin secretion (Homo sapiens)
Free fatty acids regulate insulin secretion (Homo sapiens)
Intracellular metabolism of fatty acids regulates insulin secretion (Homo sapiens)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)
PPi [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)
PPi [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Aspartate and asparagine metabolism (Homo sapiens)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)
PPi [cytosol]
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)
PPi [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
SeMet is converted to AdoSeMet by MAT (Homo sapiens)
PPi [cytosol]
Selenocysteine synthesis (Homo sapiens)
tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)
PPi [cytosol]
tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)
PPi [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
PPi [cytosol]
Urea cycle (Homo sapiens)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)
PPi [cytosol]
Metabolism of carbohydrates (Homo sapiens)
Glycogen metabolism (Homo sapiens)
Glycogen synthesis (Homo sapiens)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)
PPi [cytosol]
Glycosaminoglycan metabolism (Homo sapiens)
Transport and synthesis of PAPS (Homo sapiens)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)
PPi [cytosol]
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Fatty acyl-CoA biosynthesis (Homo sapiens)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Homo sapiens)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Homo sapiens)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)
PPi [cytosol]
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)
PPi [cytosol]
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
PPi [cytosol]
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
PPi [cytosol]
Cholesterol biosynthesis (Homo sapiens)
FDPS dimer transfers IPPP to DMAPP (Homo sapiens)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Homo sapiens)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Homo sapiens)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Homo sapiens)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Homo sapiens)
PPi [cytosol]
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Synthesis of PC (Homo sapiens)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)
PPi [cytosol]
Synthesis of PE (Homo sapiens)
PETA and CTP are condensed to CDP-ETA by PCY2 (Homo sapiens)
PPi [cytosol]
Synthesis of PI (Homo sapiens)
PA is converted to CDP-DAG by CDS1 (Homo sapiens)
PPi [cytosol]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
DCTPP1 hydrolyses 5idCTP (Homo sapiens)
PPi [cytosol]
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
Pyrimidine biosynthesis (Homo sapiens)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
PPi [cytosol]
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
ITPA hydrolyses ITP to IMP (Homo sapiens)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Homo sapiens)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Homo sapiens)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
PPi [cytosol]
Nucleotide salvage (Homo sapiens)
Purine salvage (Homo sapiens)
APRT catalyzes the conversion of adenine to AMP (Homo sapiens)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)
PPi [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
PPi [cytosol]
HLCS biotinylates ACACB (Homo sapiens)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Homo sapiens)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Homo sapiens)
Cyclisation of GTP to precursor Z (Homo sapiens)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Homo sapiens)
PPi [cytosol]
Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)
PPi [cytosol]
Nicotinate metabolism (Homo sapiens)
NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)
PPi [cytosol]
Nicotinamide salvaging (Homo sapiens)
NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)
PPi [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Homo sapiens)
FLAD1 phosphorylates FMN (Homo sapiens)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
Coenzyme A biosynthesis (Homo sapiens)
2xPPCS ligates PPanK with Cys (Homo sapiens)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)
PPi [cytosol]
Pyrophosphate hydrolysis (Homo sapiens)
LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
PPi [cytosol]
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
TUT4,TUT7 oligouridylate mRNA (Homo sapiens)
PPi [cytosol]
tRNA processing (Homo sapiens)
tRNA modification in the nucleus and cytosol (Homo sapiens)
THG1L transfers GMP to 5' end of tRNA(His) (Homo sapiens)
PPi [cytosol]
TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)
PPi [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
GDP-fucose biosynthesis (Homo sapiens)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)
PPi [cytosol]
Synthesis of Dolichyl-phosphate (Homo sapiens)
Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)
PPi [cytosol]
Synthesis of GDP-mannose (Homo sapiens)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Homo sapiens)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Synthesis of diphthamide-EEF2 (Homo sapiens)
DPH6 ligates ammonium to diphthine-EEF2 (Homo sapiens)
PPi [cytosol]
Neddylation (Homo sapiens)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)
PPi [cytosol]
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)
PPi [cytosol]
UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
PPi [cytosol]
Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)
PPi [cytosol]
RAB geranylgeranylation (Homo sapiens)
RGGT geranylgeranylates RAB proteins (Homo sapiens)
PPi [cytosol]
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
PPi [cytosol]
alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)
PPi [cytosol]
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)
PPi [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)
PPi [cytosol]
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)
PPi [cytosol]
GUCYs converts GTP to cGMP (Homo sapiens)
PPi [cytosol]
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
Adenylate cyclase produces cAMP (Homo sapiens)
PPi [cytosol]
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
pro-RAS proteins are farnesylated (Homo sapiens)
PPi [cytosol]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
PPi [cytosol]
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
Adenylate cyclase activating pathway (Homo sapiens)
Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)
PPi [cytosol]
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
Adenylate cyclase produces cAMP (Homo sapiens)
PPi [cytosol]
G alpha (s) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
PPi [cytosol]
GPER1 signaling (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
PPi [cytosol]
G alpha (z) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
PPi [cytosol]
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)
PPi [cytosol]
Transport of small molecules (Homo sapiens)
Aquaporin-mediated transport (Homo sapiens)
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
PPi [cytosol]
Miscellaneous transport and binding events (Homo sapiens)
ANKH transports PPi from cytosol to extracellular region (Homo sapiens)
PPi [cytosol]
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Mus musculus)
Dephosphorylation of phospho-Cdh1 (Mus musculus)
PPi [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
Nuclear events mediated by NFE2L2 (Mus musculus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Mus musculus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)
PPi [cytosol]
Drug ADME (Mus musculus)
Azathioprine ADME (Mus musculus)
GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)
PPi [cytosol]
Ribavirin ADME (Mus musculus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)
PPi [cytosol]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
E1 mediated ubiquitin activation (Mus musculus)
PPi [cytosol]
Polyubiquitination of substrate (Mus musculus)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
PPi [cytosol]
Rap1 signalling (Mus musculus)
Rap1 signal termination by Rap1GAPs (Mus musculus)
PPi [cytosol]
Regulation of T cell activation by CD28 family (Mus musculus)
Co-inhibition by PD-1 (Mus musculus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
PPi [cytosol]
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
ISG15 antiviral mechanism (Mus musculus)
Activation of ISG15 by UBA7 E1 ligase (Mus musculus)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Mus musculus)
PPi [cytosol]
ISGylation of IRF3 (Mus musculus)
PPi [cytosol]
ISGylation of host protein filamin B (Mus musculus)
PPi [cytosol]
ISGylation of host proteins (Mus musculus)
PPi [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)
PPi [cytosol]
PKR-mediated signaling (Mus musculus)
ISGylation of PKR (Mus musculus)
PPi [cytosol]
Modulation of host responses by IFN-stimulated genes (Mus musculus)
ISGylation of DDX58 (RIG-I) (Mus musculus)
PPi [cytosol]
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)
PPi [cytosol]
TRAF6 oligomer autoubiquitinates (Mus musculus)
PPi [cytosol]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
Auto-ubiquitination of TRAF6 (Mus musculus)
PPi [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Ethanol oxidation (Mus musculus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)
PPi [cytosol]
Phase II - Conjugation of compounds (Mus musculus)
Cytosolic sulfonation of small molecules (Mus musculus)
Transport and synthesis of PAPS (Mus musculus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)
PPi [cytosol]
Glucuronidation (Mus musculus)
Formation of the active cofactor, UDP-glucuronate (Mus musculus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)
PPi [cytosol]
Methylation (Mus musculus)
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)
PPi [cytosol]
Integration of energy metabolism (Mus musculus)
Regulation of insulin secretion (Mus musculus)
Free fatty acids regulate insulin secretion (Mus musculus)
Intracellular metabolism of fatty acids regulates insulin secretion (Mus musculus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)
PPi [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Aspartate and asparagine metabolism (Mus musculus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)
PPi [cytosol]
Selenoamino acid metabolism (Mus musculus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Mus musculus)
SeMet is converted to AdoSeMet by MAT (Mus musculus)
PPi [cytosol]
Sulfur amino acid metabolism (Mus musculus)
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
PPi [cytosol]
Urea cycle (Mus musculus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)
PPi [cytosol]
Metabolism of carbohydrates (Mus musculus)
Glycogen metabolism (Mus musculus)
Glycogen synthesis (Mus musculus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)
PPi [cytosol]
Glycosaminoglycan metabolism (Mus musculus)
Transport and synthesis of PAPS (Mus musculus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)
PPi [cytosol]
Metabolism of lipids (Mus musculus)
Fatty acid metabolism (Mus musculus)
Fatty acyl-CoA biosynthesis (Mus musculus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Mus musculus)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Mus musculus)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)
PPi [cytosol]
Ketone body metabolism (Mus musculus)
Synthesis of Ketone Bodies (Mus musculus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)
PPi [cytosol]
Metabolism of steroids (Mus musculus)
Bile acid and bile salt metabolism (Mus musculus)
Recycling of bile acids and salts (Mus musculus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
PPi [cytosol]
Synthesis of bile acids and bile salts (Mus musculus)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Mus musculus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Mus musculus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
PPi [cytosol]
Cholesterol biosynthesis (Mus musculus)
FDPS dimer transfers IPPP to DMAPP (Mus musculus)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Mus musculus)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Mus musculus)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Mus musculus)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)
PPi [cytosol]
Phospholipid metabolism (Mus musculus)
Glycerophospholipid biosynthesis (Mus musculus)
Synthesis of PC (Mus musculus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)
PPi [cytosol]
Synthesis of PE (Mus musculus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)
PPi [cytosol]
Synthesis of PI (Mus musculus)
PA is converted to CDP-DAG by CDS1 (Mus musculus)
PPi [cytosol]
Metabolism of nucleotides (Mus musculus)
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
PPi [cytosol]
Pyrimidine biosynthesis (Mus musculus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)
PPi [cytosol]
Nucleotide catabolism (Mus musculus)
Purine catabolism (Mus musculus)
ITPA hydrolyses ITP to IMP (Mus musculus)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Mus musculus)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Mus musculus)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Mus musculus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
PPi [cytosol]
Nucleotide salvage (Mus musculus)
Purine salvage (Mus musculus)
APRT catalyzes the conversion of adenine to AMP (Mus musculus)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)
PPi [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Biotin transport and metabolism (Mus musculus)
HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Mus musculus)
PPi [cytosol]
HLCS biotinylates ACACB (Mus musculus)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Mus musculus)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Mus musculus)
Cyclisation of GTP to precursor Z (Mus musculus)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Mus musculus)
PPi [cytosol]
Nicotinate metabolism (Mus musculus)
NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Mus musculus)
PPi [cytosol]
Nicotinamide salvaging (Mus musculus)
NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)
PPi [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Mus musculus)
FLAD1 phosphorylates FMN (Mus musculus)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Mus musculus)
Coenzyme A biosynthesis (Mus musculus)
2xPPCS ligates PPanK with Cys (Mus musculus)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)
PPi [cytosol]
Pyrophosphate hydrolysis (Mus musculus)
LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
PPi [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
GDP-fucose biosynthesis (Mus musculus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)
PPi [cytosol]
Synthesis of GDP-mannose (Mus musculus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Mus musculus)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Mus musculus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Mus musculus)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
Synthesis of diphthamide-EEF2 (Mus musculus)
DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)
PPi [cytosol]
Neddylation (Mus musculus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Mus musculus)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)
PPi [cytosol]
Protein ubiquitination (Mus musculus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Mus musculus)
UBA1 adenylates ubiquitin in the cytosol (Mus musculus)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Mus musculus)
PPi [cytosol]
RAB geranylgeranylation (Mus musculus)
RGGT geranylgeranylates RAB proteins (Mus musculus)
PPi [cytosol]
Translation (Mus musculus)
tRNA Aminoacylation (Mus musculus)
Cytosolic tRNA aminoacylation (Mus musculus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
PPi [cytosol]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
The phototransduction cascade (Mus musculus)
Inactivation, recovery and regulation of the phototransduction cascade (Mus musculus)
FNTA:FNTB transfers FARN to GNGT1 (Mus musculus)
PPi [cytosol]
GUCYs converts GTP to cGMP (Mus musculus)
PPi [cytosol]
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
DAG and IP3 signaling (Mus musculus)
CaM pathway (Mus musculus)
Calmodulin induced events (Mus musculus)
PKA-mediated phosphorylation of CREB (Mus musculus)
PKA activation (Mus musculus)
Adenylate cyclase produces cAMP (Mus musculus)
PPi [cytosol]
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS processing (Mus musculus)
pro-RAS proteins are farnesylated (Mus musculus)
PPi [cytosol]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Opioid Signalling (Mus musculus)
G-protein mediated events (Mus musculus)
Adenylate cyclase activating pathway (Mus musculus)
Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)
PPi [cytosol]
PLC beta mediated events (Mus musculus)
Ca-dependent events (Mus musculus)
CaM pathway (Mus musculus)
Calmodulin induced events (Mus musculus)
PKA-mediated phosphorylation of CREB (Mus musculus)
PKA activation (Mus musculus)
Adenylate cyclase produces cAMP (Mus musculus)
PPi [cytosol]
Signaling by Hedgehog (Mus musculus)
Hedgehog 'off' state (Mus musculus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)
PPi [cytosol]
Transport of small molecules (Mus musculus)
Miscellaneous transport and binding events (Mus musculus)
ANKH transports PPi from cytosol to extracellular region (Mus musculus)
PPi [cytosol]
Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
Dimycocersyl phthiocerol biosynthesis (Mycobacterium tuberculosis)
FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)
PPi [cytosol]
Mycothiol metabolism (Mycobacterium tuberculosis)
Mycothiol biosynthesis (Mycobacterium tuberculosis)
glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol (Mycobacterium tuberculosis)
PPi [cytosol]
Sulfur compound metabolism (Mycobacterium tuberculosis)
Sulfate assimilation (Mycobacterium tuberculosis)
sulfate is activated to APS (Mycobacterium tuberculosis)
PPi [cytosol]
Drug ADME (Plasmodium falciparum)
Azathioprine ADME (Plasmodium falciparum)
GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)
PPi [cytosol]
Ribavirin ADME (Plasmodium falciparum)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)
PPi [cytosol]
Immune System (Plasmodium falciparum)
Adaptive Immune System (Plasmodium falciparum)
Class I MHC mediated antigen processing & presentation (Plasmodium falciparum)
Antigen processing: Ubiquitination & Proteasome degradation (Plasmodium falciparum)
E1 mediated ubiquitin activation (Plasmodium falciparum)
PPi [cytosol]
Polyubiquitination of substrate (Plasmodium falciparum)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Plasmodium falciparum)
PPi [cytosol]
Cytokine Signaling in Immune system (Plasmodium falciparum)
Interferon Signaling (Plasmodium falciparum)
Antiviral mechanism by IFN-stimulated genes (Plasmodium falciparum)
ISG15 antiviral mechanism (Plasmodium falciparum)
Activation of ISG15 by UBA7 E1 ligase (Plasmodium falciparum)
PPi [cytosol]
Metabolism (Plasmodium falciparum)
Biological oxidations (Plasmodium falciparum)
Phase I - Functionalization of compounds (Plasmodium falciparum)
Ethanol oxidation (Plasmodium falciparum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)
PPi [cytosol]
Phase II - Conjugation of compounds (Plasmodium falciparum)
Methylation (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
PPi [cytosol]
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Aspartate and asparagine metabolism (Plasmodium falciparum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)
PPi [cytosol]
Selenoamino acid metabolism (Plasmodium falciparum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Plasmodium falciparum)
SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)
PPi [cytosol]
Sulfur amino acid metabolism (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
PPi [cytosol]
Metabolism of lipids (Plasmodium falciparum)
Fatty acid metabolism (Plasmodium falciparum)
Fatty acyl-CoA biosynthesis (Plasmodium falciparum)
Synthesis of very long-chain fatty acyl-CoAs (Plasmodium falciparum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)
PPi [cytosol]
Metabolism of steroids (Plasmodium falciparum)
Cholesterol biosynthesis (Plasmodium falciparum)
FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)
PPi [cytosol]
Phospholipid metabolism (Plasmodium falciparum)
Glycerophospholipid biosynthesis (Plasmodium falciparum)
Synthesis of PC (Plasmodium falciparum)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)
PPi [cytosol]
Synthesis of PE (Plasmodium falciparum)
PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)
PPi [cytosol]
Synthesis of PI (Plasmodium falciparum)
PA is converted to CDP-DAG by CDS1 (Plasmodium falciparum)
PPi [cytosol]
Metabolism of nucleotides (Plasmodium falciparum)
Nucleotide biosynthesis (Plasmodium falciparum)
Purine ribonucleoside monophosphate biosynthesis (Plasmodium falciparum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
PPi [cytosol]
Nucleotide catabolism (Plasmodium falciparum)
Purine catabolism (Plasmodium falciparum)
ITPA hydrolyses ITP to IMP (Plasmodium falciparum)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Plasmodium falciparum)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Plasmodium falciparum)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Plasmodium falciparum)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)
PPi [cytosol]
Nucleotide salvage (Plasmodium falciparum)
Purine salvage (Plasmodium falciparum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)
PPi [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Biotin transport and metabolism (Plasmodium falciparum)
HLCS biotinylates ACACA:Mn2+ (Plasmodium falciparum)
PPi [cytosol]
HLCS biotinylates ACACB (Plasmodium falciparum)
PPi [cytosol]
Nicotinate metabolism (Plasmodium falciparum)
NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)
PPi [cytosol]
Nicotinamide salvaging (Plasmodium falciparum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Plasmodium falciparum)
FLAD1 phosphorylates FMN (Plasmodium falciparum)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Plasmodium falciparum)
Coenzyme A biosynthesis (Plasmodium falciparum)
2xPPCS ligates PPanK with Cys (Plasmodium falciparum)
PPi [cytosol]
Pyrophosphate hydrolysis (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
PPi [cytosol]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Asparagine N-linked glycosylation (Plasmodium falciparum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Plasmodium falciparum)
Synthesis of substrates in N-glycan biosythesis (Plasmodium falciparum)
Synthesis of UDP-N-acetyl-glucosamine (Plasmodium falciparum)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Plasmodium falciparum)
PPi [cytosol]
Neddylation (Plasmodium falciparum)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Plasmodium falciparum)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Plasmodium falciparum)
PPi [cytosol]
Protein ubiquitination (Plasmodium falciparum)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Plasmodium falciparum)
UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)
PPi [cytosol]
RAB geranylgeranylation (Plasmodium falciparum)
RGGT geranylgeranylates RAB proteins (Plasmodium falciparum)
PPi [cytosol]
Translation (Plasmodium falciparum)
tRNA Aminoacylation (Plasmodium falciparum)
Cytosolic tRNA aminoacylation (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
PPi [cytosol]
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Regulation of mitotic cell cycle (Rattus norvegicus)
APC/C-mediated degradation of cell cycle proteins (Rattus norvegicus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Rattus norvegicus)
Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)
PPi [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
Nuclear events mediated by NFE2L2 (Rattus norvegicus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Rattus norvegicus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Rattus norvegicus)
PPi [cytosol]
Drug ADME (Rattus norvegicus)
Azathioprine ADME (Rattus norvegicus)
GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)
PPi [cytosol]
Ribavirin ADME (Rattus norvegicus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)
PPi [cytosol]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
E1 mediated ubiquitin activation (Rattus norvegicus)
PPi [cytosol]
Polyubiquitination of substrate (Rattus norvegicus)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
PPi [cytosol]
Rap1 signalling (Rattus norvegicus)
Rap1 signal termination by Rap1GAPs (Rattus norvegicus)
PPi [cytosol]
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-inhibition by PD-1 (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
PPi [cytosol]
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Antiviral mechanism by IFN-stimulated genes (Rattus norvegicus)
ISG15 antiviral mechanism (Rattus norvegicus)
Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Rattus norvegicus)
PPi [cytosol]
ISGylation of IRF3 (Rattus norvegicus)
PPi [cytosol]
ISGylation of host protein filamin B (Rattus norvegicus)
PPi [cytosol]
ISGylation of host proteins (Rattus norvegicus)
PPi [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)
PPi [cytosol]
PKR-mediated signaling (Rattus norvegicus)
ISGylation of PKR (Rattus norvegicus)
PPi [cytosol]
Modulation of host responses by IFN-stimulated genes (Rattus norvegicus)
ISGylation of DDX58 (RIG-I) (Rattus norvegicus)
PPi [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
Ethanol oxidation (Rattus norvegicus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)
PPi [cytosol]
Phase II - Conjugation of compounds (Rattus norvegicus)
Cytosolic sulfonation of small molecules (Rattus norvegicus)
Transport and synthesis of PAPS (Rattus norvegicus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)
PPi [cytosol]
Glucuronidation (Rattus norvegicus)
Formation of the active cofactor, UDP-glucuronate (Rattus norvegicus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)
PPi [cytosol]
Methylation (Rattus norvegicus)
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)
PPi [cytosol]
Integration of energy metabolism (Rattus norvegicus)
Regulation of insulin secretion (Rattus norvegicus)
Free fatty acids regulate insulin secretion (Rattus norvegicus)
Intracellular metabolism of fatty acids regulates insulin secretion (Rattus norvegicus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)
PPi [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Aspartate and asparagine metabolism (Rattus norvegicus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)
PPi [cytosol]
Selenoamino acid metabolism (Rattus norvegicus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Rattus norvegicus)
SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)
PPi [cytosol]
Sulfur amino acid metabolism (Rattus norvegicus)
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
PPi [cytosol]
Metabolism of carbohydrates (Rattus norvegicus)
Glycogen metabolism (Rattus norvegicus)
Glycogen synthesis (Rattus norvegicus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)
PPi [cytosol]
Glycosaminoglycan metabolism (Rattus norvegicus)
Transport and synthesis of PAPS (Rattus norvegicus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)
PPi [cytosol]
Metabolism of lipids (Rattus norvegicus)
Fatty acid metabolism (Rattus norvegicus)
Fatty acyl-CoA biosynthesis (Rattus norvegicus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Rattus norvegicus)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Rattus norvegicus)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)
PPi [cytosol]
Ketone body metabolism (Rattus norvegicus)
Synthesis of Ketone Bodies (Rattus norvegicus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)
PPi [cytosol]
Metabolism of steroids (Rattus norvegicus)
Bile acid and bile salt metabolism (Rattus norvegicus)
Recycling of bile acids and salts (Rattus norvegicus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
PPi [cytosol]
Synthesis of bile acids and bile salts (Rattus norvegicus)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Rattus norvegicus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
PPi [cytosol]
Cholesterol biosynthesis (Rattus norvegicus)
FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Rattus norvegicus)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)
PPi [cytosol]
Phospholipid metabolism (Rattus norvegicus)
Glycerophospholipid biosynthesis (Rattus norvegicus)
Synthesis of PC (Rattus norvegicus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)
PPi [cytosol]
Synthesis of PE (Rattus norvegicus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)
PPi [cytosol]
Synthesis of PI (Rattus norvegicus)
PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)
PPi [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
PPi [cytosol]
Pyrimidine biosynthesis (Rattus norvegicus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)
PPi [cytosol]
Nucleotide catabolism (Rattus norvegicus)
Purine catabolism (Rattus norvegicus)
ITPA hydrolyses ITP to IMP (Rattus norvegicus)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Rattus norvegicus)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Rattus norvegicus)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
PPi [cytosol]
Nucleotide salvage (Rattus norvegicus)
Purine salvage (Rattus norvegicus)
APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)
PPi [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Biotin transport and metabolism (Rattus norvegicus)
HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Rattus norvegicus)
PPi [cytosol]
HLCS biotinylates ACACB (Rattus norvegicus)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Rattus norvegicus)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Rattus norvegicus)
Cyclisation of GTP to precursor Z (Rattus norvegicus)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)
PPi [cytosol]
Nicotinate metabolism (Rattus norvegicus)
NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)
PPi [cytosol]
Nicotinamide salvaging (Rattus norvegicus)
NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)
PPi [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Rattus norvegicus)
FLAD1 phosphorylates FMN (Rattus norvegicus)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Rattus norvegicus)
Coenzyme A biosynthesis (Rattus norvegicus)
2xPPCS ligates PPanK with Cys (Rattus norvegicus)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)
PPi [cytosol]
Pyrophosphate hydrolysis (Rattus norvegicus)
LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
PPi [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
GDP-fucose biosynthesis (Rattus norvegicus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)
PPi [cytosol]
Synthesis of GDP-mannose (Rattus norvegicus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Rattus norvegicus)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Rattus norvegicus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Rattus norvegicus)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Rattus norvegicus)
Synthesis of diphthamide-EEF2 (Rattus norvegicus)
DPH6 ligates ammonium to diphthine-EEF2 (Rattus norvegicus)
PPi [cytosol]
Neddylation (Rattus norvegicus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Rattus norvegicus)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Rattus norvegicus)
PPi [cytosol]
Protein ubiquitination (Rattus norvegicus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Rattus norvegicus)
UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)
PPi [cytosol]
RAB geranylgeranylation (Rattus norvegicus)
RGGT geranylgeranylates RAB proteins (Rattus norvegicus)
PPi [cytosol]
Translation (Rattus norvegicus)
tRNA Aminoacylation (Rattus norvegicus)
Cytosolic tRNA aminoacylation (Rattus norvegicus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
PPi [cytosol]
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
The phototransduction cascade (Rattus norvegicus)
Inactivation, recovery and regulation of the phototransduction cascade (Rattus norvegicus)
FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)
PPi [cytosol]
GUCYs converts GTP to cGMP (Rattus norvegicus)
PPi [cytosol]
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
DAG and IP3 signaling (Rattus norvegicus)
CaM pathway (Rattus norvegicus)
Calmodulin induced events (Rattus norvegicus)
PKA-mediated phosphorylation of CREB (Rattus norvegicus)
PKA activation (Rattus norvegicus)
Adenylate cyclase produces cAMP (Rattus norvegicus)
PPi [cytosol]
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS processing (Rattus norvegicus)
pro-RAS proteins are farnesylated (Rattus norvegicus)
PPi [cytosol]
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
G-protein mediated events (Rattus norvegicus)
Adenylate cyclase activating pathway (Rattus norvegicus)
Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)
PPi [cytosol]
PLC beta mediated events (Rattus norvegicus)
Ca-dependent events (Rattus norvegicus)
CaM pathway (Rattus norvegicus)
Calmodulin induced events (Rattus norvegicus)
PKA-mediated phosphorylation of CREB (Rattus norvegicus)
PKA activation (Rattus norvegicus)
Adenylate cyclase produces cAMP (Rattus norvegicus)
PPi [cytosol]
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog 'off' state (Rattus norvegicus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)
PPi [cytosol]
Transport of small molecules (Rattus norvegicus)
Miscellaneous transport and binding events (Rattus norvegicus)
ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)
PPi [cytosol]
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
Regulation of mitotic cell cycle (Saccharomyces cerevisiae)
APC/C-mediated degradation of cell cycle proteins (Saccharomyces cerevisiae)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Saccharomyces cerevisiae)
Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)
PPi [cytosol]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
Nuclear events mediated by NFE2L2 (Saccharomyces cerevisiae)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Saccharomyces cerevisiae)
SRXN1 reduces hyperoxidized PRDX1 dimer (Saccharomyces cerevisiae)
PPi [cytosol]
Drug ADME (Saccharomyces cerevisiae)
Azathioprine ADME (Saccharomyces cerevisiae)
GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
PPi [cytosol]
Ribavirin ADME (Saccharomyces cerevisiae)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)
PPi [cytosol]
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
E1 mediated ubiquitin activation (Saccharomyces cerevisiae)
PPi [cytosol]
Polyubiquitination of substrate (Saccharomyces cerevisiae)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism (Saccharomyces cerevisiae)
Biological oxidations (Saccharomyces cerevisiae)
Phase I - Functionalization of compounds (Saccharomyces cerevisiae)
Ethanol oxidation (Saccharomyces cerevisiae)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)
PPi [cytosol]
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Cytosolic sulfonation of small molecules (Saccharomyces cerevisiae)
Transport and synthesis of PAPS (Saccharomyces cerevisiae)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)
PPi [cytosol]
Glucuronidation (Saccharomyces cerevisiae)
Formation of the active cofactor, UDP-glucuronate (Saccharomyces cerevisiae)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)
PPi [cytosol]
Methylation (Saccharomyces cerevisiae)
MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
PPi [cytosol]
Integration of energy metabolism (Saccharomyces cerevisiae)
Regulation of insulin secretion (Saccharomyces cerevisiae)
Free fatty acids regulate insulin secretion (Saccharomyces cerevisiae)
Intracellular metabolism of fatty acids regulates insulin secretion (Saccharomyces cerevisiae)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Aspartate and asparagine metabolism (Saccharomyces cerevisiae)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)
PPi [cytosol]
Selenoamino acid metabolism (Saccharomyces cerevisiae)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Saccharomyces cerevisiae)
SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)
PPi [cytosol]
Sulfur amino acid metabolism (Saccharomyces cerevisiae)
MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Glycogen metabolism (Saccharomyces cerevisiae)
Glycogen synthesis (Saccharomyces cerevisiae)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)
PPi [cytosol]
Glycosaminoglycan metabolism (Saccharomyces cerevisiae)
Transport and synthesis of PAPS (Saccharomyces cerevisiae)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism of lipids (Saccharomyces cerevisiae)
Fatty acid metabolism (Saccharomyces cerevisiae)
Fatty acyl-CoA biosynthesis (Saccharomyces cerevisiae)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Saccharomyces cerevisiae)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Saccharomyces cerevisiae)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism of steroids (Saccharomyces cerevisiae)
Bile acid and bile salt metabolism (Saccharomyces cerevisiae)
Recycling of bile acids and salts (Saccharomyces cerevisiae)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
PPi [cytosol]
Synthesis of bile acids and bile salts (Saccharomyces cerevisiae)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Saccharomyces cerevisiae)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Saccharomyces cerevisiae)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
PPi [cytosol]
Cholesterol biosynthesis (Saccharomyces cerevisiae)
FDPS dimer transfers IPPP to DMAPP (Saccharomyces cerevisiae)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Saccharomyces cerevisiae)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)
PPi [cytosol]
Phospholipid metabolism (Saccharomyces cerevisiae)
Glycerophospholipid biosynthesis (Saccharomyces cerevisiae)
Synthesis of PC (Saccharomyces cerevisiae)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)
PPi [cytosol]
Synthesis of PE (Saccharomyces cerevisiae)
PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)
PPi [cytosol]
Synthesis of PI (Saccharomyces cerevisiae)
PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism of nucleotides (Saccharomyces cerevisiae)
Nucleotide biosynthesis (Saccharomyces cerevisiae)
Purine ribonucleoside monophosphate biosynthesis (Saccharomyces cerevisiae)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
PPi [cytosol]
Nucleotide catabolism (Saccharomyces cerevisiae)
Purine catabolism (Saccharomyces cerevisiae)
ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)
PPi [cytosol]
Nucleotide salvage (Saccharomyces cerevisiae)
Purine salvage (Saccharomyces cerevisiae)
APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Biotin transport and metabolism (Saccharomyces cerevisiae)
HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)
PPi [cytosol]
HLCS biotinylates ACACB (Saccharomyces cerevisiae)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Saccharomyces cerevisiae)
PPi [cytosol]
Nicotinate metabolism (Saccharomyces cerevisiae)
NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)
PPi [cytosol]
Nicotinamide salvaging (Saccharomyces cerevisiae)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Saccharomyces cerevisiae)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Saccharomyces cerevisiae)
FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Saccharomyces cerevisiae)
Coenzyme A biosynthesis (Saccharomyces cerevisiae)
2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)
PPi [cytosol]
Pyrophosphate hydrolysis (Saccharomyces cerevisiae)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)
PPi [cytosol]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Asparagine N-linked glycosylation (Saccharomyces cerevisiae)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Saccharomyces cerevisiae)
Synthesis of substrates in N-glycan biosythesis (Saccharomyces cerevisiae)
Synthesis of UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Saccharomyces cerevisiae)
Synthesis of diphthamide-EEF2 (Saccharomyces cerevisiae)
DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)
PPi [cytosol]
Neddylation (Saccharomyces cerevisiae)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Saccharomyces cerevisiae)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Saccharomyces cerevisiae)
PPi [cytosol]
Protein ubiquitination (Saccharomyces cerevisiae)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Saccharomyces cerevisiae)
UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
PPi [cytosol]
RAB geranylgeranylation (Saccharomyces cerevisiae)
RGGT geranylgeranylates RAB proteins (Saccharomyces cerevisiae)
PPi [cytosol]
Translation (Saccharomyces cerevisiae)
tRNA Aminoacylation (Saccharomyces cerevisiae)
Cytosolic tRNA aminoacylation (Saccharomyces cerevisiae)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)
PPi [cytosol]
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
Regulation of mitotic cell cycle (Schizosaccharomyces pombe)
APC/C-mediated degradation of cell cycle proteins (Schizosaccharomyces pombe)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Schizosaccharomyces pombe)
Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)
PPi [cytosol]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to chemical stress (Schizosaccharomyces pombe)
KEAP1-NFE2L2 pathway (Schizosaccharomyces pombe)
Nuclear events mediated by NFE2L2 (Schizosaccharomyces pombe)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Schizosaccharomyces pombe)
SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)
PPi [cytosol]
Drug ADME (Schizosaccharomyces pombe)
Azathioprine ADME (Schizosaccharomyces pombe)
GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
PPi [cytosol]
Ribavirin ADME (Schizosaccharomyces pombe)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)
PPi [cytosol]
Immune System (Schizosaccharomyces pombe)
Adaptive Immune System (Schizosaccharomyces pombe)
Class I MHC mediated antigen processing & presentation (Schizosaccharomyces pombe)
Antigen processing: Ubiquitination & Proteasome degradation (Schizosaccharomyces pombe)
E1 mediated ubiquitin activation (Schizosaccharomyces pombe)
PPi [cytosol]
Polyubiquitination of substrate (Schizosaccharomyces pombe)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism (Schizosaccharomyces pombe)
Biological oxidations (Schizosaccharomyces pombe)
Phase I - Functionalization of compounds (Schizosaccharomyces pombe)
Ethanol oxidation (Schizosaccharomyces pombe)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)
PPi [cytosol]
Phase II - Conjugation of compounds (Schizosaccharomyces pombe)
Cytosolic sulfonation of small molecules (Schizosaccharomyces pombe)
Transport and synthesis of PAPS (Schizosaccharomyces pombe)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)
PPi [cytosol]
Glucuronidation (Schizosaccharomyces pombe)
Formation of the active cofactor, UDP-glucuronate (Schizosaccharomyces pombe)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Schizosaccharomyces pombe)
PPi [cytosol]
Methylation (Schizosaccharomyces pombe)
MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)
PPi [cytosol]
Integration of energy metabolism (Schizosaccharomyces pombe)
Regulation of insulin secretion (Schizosaccharomyces pombe)
Free fatty acids regulate insulin secretion (Schizosaccharomyces pombe)
Intracellular metabolism of fatty acids regulates insulin secretion (Schizosaccharomyces pombe)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Aspartate and asparagine metabolism (Schizosaccharomyces pombe)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)
PPi [cytosol]
Selenoamino acid metabolism (Schizosaccharomyces pombe)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Schizosaccharomyces pombe)
SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)
PPi [cytosol]
Sulfur amino acid metabolism (Schizosaccharomyces pombe)
MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Glycogen metabolism (Schizosaccharomyces pombe)
Glycogen synthesis (Schizosaccharomyces pombe)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Schizosaccharomyces pombe)
PPi [cytosol]
Glycosaminoglycan metabolism (Schizosaccharomyces pombe)
Transport and synthesis of PAPS (Schizosaccharomyces pombe)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism of lipids (Schizosaccharomyces pombe)
Fatty acid metabolism (Schizosaccharomyces pombe)
Fatty acyl-CoA biosynthesis (Schizosaccharomyces pombe)
Synthesis of very long-chain fatty acyl-CoAs (Schizosaccharomyces pombe)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism of steroids (Schizosaccharomyces pombe)
Cholesterol biosynthesis (Schizosaccharomyces pombe)
FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Schizosaccharomyces pombe)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Schizosaccharomyces pombe)
PPi [cytosol]
Phospholipid metabolism (Schizosaccharomyces pombe)
Glycerophospholipid biosynthesis (Schizosaccharomyces pombe)
Synthesis of PC (Schizosaccharomyces pombe)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)
PPi [cytosol]
Synthesis of PE (Schizosaccharomyces pombe)
PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)
PPi [cytosol]
Synthesis of PI (Schizosaccharomyces pombe)
PA is converted to CDP-DAG by CDS1 (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism of nucleotides (Schizosaccharomyces pombe)
Nucleotide biosynthesis (Schizosaccharomyces pombe)
Purine ribonucleoside monophosphate biosynthesis (Schizosaccharomyces pombe)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
PPi [cytosol]
Nucleotide catabolism (Schizosaccharomyces pombe)
Purine catabolism (Schizosaccharomyces pombe)
ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)
PPi [cytosol]
Nucleotide salvage (Schizosaccharomyces pombe)
Purine salvage (Schizosaccharomyces pombe)
APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Biotin transport and metabolism (Schizosaccharomyces pombe)
HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)
PPi [cytosol]
HLCS biotinylates ACACB (Schizosaccharomyces pombe)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)
PPi [cytosol]
Nicotinate metabolism (Schizosaccharomyces pombe)
NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)
PPi [cytosol]
Nicotinamide salvaging (Schizosaccharomyces pombe)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Schizosaccharomyces pombe)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Schizosaccharomyces pombe)
FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Schizosaccharomyces pombe)
Coenzyme A biosynthesis (Schizosaccharomyces pombe)
2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)
PPi [cytosol]
Pyrophosphate hydrolysis (Schizosaccharomyces pombe)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)
PPi [cytosol]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Asparagine N-linked glycosylation (Schizosaccharomyces pombe)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Schizosaccharomyces pombe)
Synthesis of substrates in N-glycan biosythesis (Schizosaccharomyces pombe)
Synthesis of GDP-mannose (Schizosaccharomyces pombe)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Schizosaccharomyces pombe)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Schizosaccharomyces pombe)
Synthesis of diphthamide-EEF2 (Schizosaccharomyces pombe)
DPH6 ligates ammonium to diphthine-EEF2 (Schizosaccharomyces pombe)
PPi [cytosol]
Neddylation (Schizosaccharomyces pombe)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Schizosaccharomyces pombe)
PPi [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)
PPi [cytosol]
Protein ubiquitination (Schizosaccharomyces pombe)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Schizosaccharomyces pombe)
UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)
PPi [cytosol]
RAB geranylgeranylation (Schizosaccharomyces pombe)
RGGT geranylgeranylates RAB proteins (Schizosaccharomyces pombe)
PPi [cytosol]
Translation (Schizosaccharomyces pombe)
tRNA Aminoacylation (Schizosaccharomyces pombe)
Cytosolic tRNA aminoacylation (Schizosaccharomyces pombe)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)
PPi [cytosol]
Cell Cycle (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
Regulation of mitotic cell cycle (Sus scrofa)
APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Sus scrofa)
Dephosphorylation of phospho-Cdh1 (Sus scrofa)
PPi [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
KEAP1-NFE2L2 pathway (Sus scrofa)
Nuclear events mediated by NFE2L2 (Sus scrofa)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Sus scrofa)
SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)
PPi [cytosol]
Drug ADME (Sus scrofa)
Azathioprine ADME (Sus scrofa)
GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
PPi [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Sus scrofa)
PPi [cytosol]
Ribavirin ADME (Sus scrofa)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)
PPi [cytosol]
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
E1 mediated ubiquitin activation (Sus scrofa)
PPi [cytosol]
Polyubiquitination of substrate (Sus scrofa)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
PPi [cytosol]
Rap1 signalling (Sus scrofa)
Rap1 signal termination by Rap1GAPs (Sus scrofa)
PPi [cytosol]
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-inhibition by PD-1 (Sus scrofa)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
PPi [cytosol]
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Antiviral mechanism by IFN-stimulated genes (Sus scrofa)
ISG15 antiviral mechanism (Sus scrofa)
Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)
PPi [cytosol]
ISGylation of E2 conjugating enzymes (Sus scrofa)
PPi [cytosol]
ISGylation of IRF3 (Sus scrofa)
PPi [cytosol]
ISGylation of host protein filamin B (Sus scrofa)
PPi [cytosol]
ISGylation of host proteins (Sus scrofa)
PPi [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)
PPi [cytosol]
PKR-mediated signaling (Sus scrofa)
ISGylation of PKR (Sus scrofa)
PPi [cytosol]
Modulation of host responses by IFN-stimulated genes (Sus scrofa)
ISGylation of DDX58 (RIG-I) (Sus scrofa)
PPi [cytosol]
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)
PPi [cytosol]
TRAF6 oligomer autoubiquitinates (Sus scrofa)
PPi [cytosol]
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
Auto-ubiquitination of TRAF6 (Sus scrofa)
PPi [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
Ethanol oxidation (Sus scrofa)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)
PPi [cytosol]
Phase II - Conjugation of compounds (Sus scrofa)
Cytosolic sulfonation of small molecules (Sus scrofa)
Transport and synthesis of PAPS (Sus scrofa)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)
PPi [cytosol]
Glucuronidation (Sus scrofa)
Formation of the active cofactor, UDP-glucuronate (Sus scrofa)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Sus scrofa)
PPi [cytosol]
Methylation (Sus scrofa)
MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)
PPi [cytosol]
Integration of energy metabolism (Sus scrofa)
Regulation of insulin secretion (Sus scrofa)
Free fatty acids regulate insulin secretion (Sus scrofa)
Intracellular metabolism of fatty acids regulates insulin secretion (Sus scrofa)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)
PPi [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Aspartate and asparagine metabolism (Sus scrofa)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)
PPi [cytosol]
Selenoamino acid metabolism (Sus scrofa)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Sus scrofa)
SeMet is converted to AdoSeMet by MAT (Sus scrofa)
PPi [cytosol]
Sulfur amino acid metabolism (Sus scrofa)
MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)
PPi [cytosol]
Urea cycle (Sus scrofa)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)
PPi [cytosol]
Metabolism of carbohydrates (Sus scrofa)
Glycogen metabolism (Sus scrofa)
Glycogen synthesis (Sus scrofa)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Sus scrofa)
PPi [cytosol]
Glycosaminoglycan metabolism (Sus scrofa)
Transport and synthesis of PAPS (Sus scrofa)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)
PPi [cytosol]
Metabolism of lipids (Sus scrofa)
Fatty acid metabolism (Sus scrofa)
Fatty acyl-CoA biosynthesis (Sus scrofa)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Sus scrofa)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Sus scrofa)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Sus scrofa)
PPi [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)
PPi [cytosol]
Ketone body metabolism (Sus scrofa)
Synthesis of Ketone Bodies (Sus scrofa)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)
PPi [cytosol]
Metabolism of steroids (Sus scrofa)
Bile acid and bile salt metabolism (Sus scrofa)
Recycling of bile acids and salts (Sus scrofa)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
PPi [cytosol]
Synthesis of bile acids and bile salts (Sus scrofa)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Sus scrofa)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Sus scrofa)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
PPi [cytosol]
Cholesterol biosynthesis (Sus scrofa)
FDPS dimer transfers IPPP to DMAPP (Sus scrofa)
PPi [cytosol]
FDPS dimer transfers IPPP to GPP (Sus scrofa)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to DMAPP (Sus scrofa)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Sus scrofa)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Sus scrofa)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)
PPi [cytosol]
Phospholipid metabolism (Sus scrofa)
Glycerophospholipid biosynthesis (Sus scrofa)
Synthesis of PC (Sus scrofa)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)
PPi [cytosol]
Synthesis of PE (Sus scrofa)
PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)
PPi [cytosol]
Synthesis of PI (Sus scrofa)
PA is converted to CDP-DAG by CDS1 (Sus scrofa)
PPi [cytosol]
Metabolism of nucleotides (Sus scrofa)
Nucleotide biosynthesis (Sus scrofa)
Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
PPi [cytosol]
Pyrimidine biosynthesis (Sus scrofa)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)
PPi [cytosol]
Nucleotide catabolism (Sus scrofa)
Purine catabolism (Sus scrofa)
ITPA hydrolyses ITP to IMP (Sus scrofa)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Sus scrofa)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Sus scrofa)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Sus scrofa)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
PPi [cytosol]
Nucleotide salvage (Sus scrofa)
Purine salvage (Sus scrofa)
APRT catalyzes the conversion of adenine to AMP (Sus scrofa)
PPi [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)
PPi [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Biotin transport and metabolism (Sus scrofa)
HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Sus scrofa)
PPi [cytosol]
HLCS biotinylates ACACB (Sus scrofa)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Sus scrofa)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Sus scrofa)
Cyclisation of GTP to precursor Z (Sus scrofa)
PPi [cytosol]
Molybdenum ion transfer onto molybdopterin (Sus scrofa)
PPi [cytosol]
Nicotinate metabolism (Sus scrofa)
NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)
PPi [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)
PPi [cytosol]
Nicotinamide salvaging (Sus scrofa)
NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)
PPi [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Sus scrofa)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
PPi [cytosol]
Vitamin B2 (riboflavin) metabolism (Sus scrofa)
FLAD1 phosphorylates FMN (Sus scrofa)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Sus scrofa)
Coenzyme A biosynthesis (Sus scrofa)
2xPPCS ligates PPanK with Cys (Sus scrofa)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)
PPi [cytosol]
Pyrophosphate hydrolysis (Sus scrofa)
LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)
PPi [cytosol]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Sus scrofa)
Synthesis of substrates in N-glycan biosythesis (Sus scrofa)
GDP-fucose biosynthesis (Sus scrofa)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Sus scrofa)
PPi [cytosol]
Synthesis of GDP-mannose (Sus scrofa)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Sus scrofa)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Sus scrofa)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Sus scrofa)
Synthesis of diphthamide-EEF2 (Sus scrofa)
DPH6 ligates ammonium to diphthine-EEF2 (Sus scrofa)
PPi [cytosol]
Protein ubiquitination (Sus scrofa)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Sus scrofa)
UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)
PPi [cytosol]
Translation (Sus scrofa)
tRNA Aminoacylation (Sus scrofa)
Cytosolic tRNA aminoacylation (Sus scrofa)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)
PPi [cytosol]
Sensory Perception (Sus scrofa)
Visual phototransduction (Sus scrofa)
The phototransduction cascade (Sus scrofa)
Inactivation, recovery and regulation of the phototransduction cascade (Sus scrofa)
GUCYs converts GTP to cGMP (Sus scrofa)
PPi [cytosol]
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
DAG and IP3 signaling (Sus scrofa)
CaM pathway (Sus scrofa)
Calmodulin induced events (Sus scrofa)
PKA-mediated phosphorylation of CREB (Sus scrofa)
PKA activation (Sus scrofa)
Adenylate cyclase produces cAMP (Sus scrofa)
PPi [cytosol]
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Opioid Signalling (Sus scrofa)
G-protein mediated events (Sus scrofa)
Adenylate cyclase activating pathway (Sus scrofa)
Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)
PPi [cytosol]
PLC beta mediated events (Sus scrofa)
Ca-dependent events (Sus scrofa)
CaM pathway (Sus scrofa)
Calmodulin induced events (Sus scrofa)
PKA-mediated phosphorylation of CREB (Sus scrofa)
PKA activation (Sus scrofa)
Adenylate cyclase produces cAMP (Sus scrofa)
PPi [cytosol]
Signaling by Hedgehog (Sus scrofa)
Hedgehog 'off' state (Sus scrofa)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)
PPi [cytosol]
Transport of small molecules (Sus scrofa)
Miscellaneous transport and binding events (Sus scrofa)
ANKH transports PPi from cytosol to extracellular region (Sus scrofa)
PPi [cytosol]
Cell Cycle (Xenopus tropicalis)
Cell Cycle, Mitotic (Xenopus tropicalis)
Regulation of mitotic cell cycle (Xenopus tropicalis)
APC/C-mediated degradation of cell cycle proteins (Xenopus tropicalis)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Xenopus tropicalis)
Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)
PPi [cytosol]
Drug ADME (Xenopus tropicalis)
Azathioprine ADME (Xenopus tropicalis)
GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
PPi [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)
PPi [cytosol]
Ribavirin ADME (Xenopus tropicalis)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)
PPi [cytosol]
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
E1 mediated ubiquitin activation (Xenopus tropicalis)
PPi [cytosol]
Polyubiquitination of substrate (Xenopus tropicalis)
PPi [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
PPi [cytosol]
Rap1 signalling (Xenopus tropicalis)
Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)
PPi [cytosol]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase I - Functionalization of compounds (Xenopus tropicalis)
Ethanol oxidation (Xenopus tropicalis)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)
PPi [cytosol]
Phase II - Conjugation of compounds (Xenopus tropicalis)
Cytosolic sulfonation of small molecules (Xenopus tropicalis)
Transport and synthesis of PAPS (Xenopus tropicalis)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)
PPi [cytosol]
Glucuronidation (Xenopus tropicalis)
Formation of the active cofactor, UDP-glucuronate (Xenopus tropicalis)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)
PPi [cytosol]
Methylation (Xenopus tropicalis)
MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)
PPi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Xenopus tropicalis)
PPi [cytosol]
Integration of energy metabolism (Xenopus tropicalis)
Regulation of insulin secretion (Xenopus tropicalis)
Free fatty acids regulate insulin secretion (Xenopus tropicalis)
Intracellular metabolism of fatty acids regulates insulin secretion (Xenopus tropicalis)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)
PPi [cytosol]
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Aspartate and asparagine metabolism (Xenopus tropicalis)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)
PPi [cytosol]
Selenoamino acid metabolism (Xenopus tropicalis)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Xenopus tropicalis)
SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)
PPi [cytosol]
Sulfur amino acid metabolism (Xenopus tropicalis)
MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)
PPi [cytosol]
Metabolism of carbohydrates (Xenopus tropicalis)
Glycogen metabolism (Xenopus tropicalis)
Glycogen synthesis (Xenopus tropicalis)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)
PPi [cytosol]
Glycosaminoglycan metabolism (Xenopus tropicalis)
Transport and synthesis of PAPS (Xenopus tropicalis)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)
PPi [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Fatty acid metabolism (Xenopus tropicalis)
Fatty acyl-CoA biosynthesis (Xenopus tropicalis)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Xenopus tropicalis)
PPi [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Xenopus tropicalis)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)
PPi [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Xenopus tropicalis)
PPi [cytosol]
Ketone body metabolism (Xenopus tropicalis)
Synthesis of Ketone Bodies (Xenopus tropicalis)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)
PPi [cytosol]
Metabolism of steroids (Xenopus tropicalis)
Bile acid and bile salt metabolism (Xenopus tropicalis)
Recycling of bile acids and salts (Xenopus tropicalis)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
PPi [cytosol]
Synthesis of bile acids and bile salts (Xenopus tropicalis)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Xenopus tropicalis)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
PPi [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
PPi [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
PPi [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Xenopus tropicalis)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
PPi [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
PPi [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
PPi [cytosol]
Cholesterol biosynthesis (Xenopus tropicalis)
GGPS1 hexamer transfers IPPP to DMAPP (Xenopus tropicalis)
PPi [cytosol]
GGPS1 hexamer transfers IPPP to GPP (Xenopus tropicalis)
PPi [cytosol]
Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)
PPi [cytosol]
Two FPP molecules dimerize to form presqualene diphosphate (Xenopus tropicalis)
PPi [cytosol]
Phospholipid metabolism (Xenopus tropicalis)
Glycerophospholipid biosynthesis (Xenopus tropicalis)
Synthesis of PC (Xenopus tropicalis)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)
PPi [cytosol]
Synthesis of PE (Xenopus tropicalis)
PETA and CTP are condensed to CDP-ETA by PCY2 (Xenopus tropicalis)
PPi [cytosol]
Synthesis of PI (Xenopus tropicalis)
PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)
PPi [cytosol]
Metabolism of nucleotides (Xenopus tropicalis)
Nucleotide biosynthesis (Xenopus tropicalis)
Purine ribonucleoside monophosphate biosynthesis (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
PPi [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
PPi [cytosol]
Pyrimidine biosynthesis (Xenopus tropicalis)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)
PPi [cytosol]
Nucleotide catabolism (Xenopus tropicalis)
Purine catabolism (Xenopus tropicalis)
ITPA hydrolyses ITP to IMP (Xenopus tropicalis)
PPi [cytosol]
ITPA hydrolyses XTP to XMP (Xenopus tropicalis)
PPi [cytosol]
ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)
PPi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)
PPi [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)
PPi [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)
PPi [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)
PPi [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)
PPi [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
PPi [cytosol]
Nucleotide salvage (Xenopus tropicalis)
Purine salvage (Xenopus tropicalis)
APRT catalyzes the conversion of adenine to AMP (Xenopus tropicalis)
PPi [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Biotin transport and metabolism (Xenopus tropicalis)
HLCS biotinylates 6x(PCCA:PCCB) (Xenopus tropicalis)
PPi [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)
PPi [cytosol]
HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)
PPi [cytosol]
HLCS biotinylates ACACB (Xenopus tropicalis)
PPi [cytosol]
HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)
PPi [cytosol]
Molybdenum cofactor biosynthesis (Xenopus tropicalis)
Cyclisation of GTP to precursor Z (Xenopus tropicalis)
PPi [cytosol]
Nicotinate metabolism (Xenopus tropicalis)
Nicotinamide salvaging (Xenopus tropicalis)
NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)
PPi [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
PPi [cytosol]
Vitamin B5 (pantothenate) metabolism (Xenopus tropicalis)
Coenzyme A biosynthesis (Xenopus tropicalis)
2xPPCS ligates PPanK with Cys (Xenopus tropicalis)
PPi [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)
PPi [cytosol]
Pyrophosphate hydrolysis (Xenopus tropicalis)
LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)
PPi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)
PPi [cytosol]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Asparagine N-linked glycosylation (Xenopus tropicalis)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Xenopus tropicalis)
Synthesis of substrates in N-glycan biosythesis (Xenopus tropicalis)
GDP-fucose biosynthesis (Xenopus tropicalis)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Xenopus tropicalis)
PPi [cytosol]
Synthesis of GDP-mannose (Xenopus tropicalis)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Xenopus tropicalis)
PPi [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Xenopus tropicalis)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Xenopus tropicalis)
PPi [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Xenopus tropicalis)
Synthesis of diphthamide-EEF2 (Xenopus tropicalis)
DPH6 ligates ammonium to diphthine-EEF2 (Xenopus tropicalis)
PPi [cytosol]
Protein ubiquitination (Xenopus tropicalis)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Xenopus tropicalis)
UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)
PPi [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)
PPi [cytosol]
Translation (Xenopus tropicalis)
tRNA Aminoacylation (Xenopus tropicalis)
Cytosolic tRNA aminoacylation (Xenopus tropicalis)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)
PPi [cytosol]
Sensory Perception (Xenopus tropicalis)
Visual phototransduction (Xenopus tropicalis)
The phototransduction cascade (Xenopus tropicalis)
Inactivation, recovery and regulation of the phototransduction cascade (Xenopus tropicalis)
FNTA:FNTB transfers FARN to GNGT1 (Xenopus tropicalis)
PPi [cytosol]
GUCYs converts GTP to cGMP (Xenopus tropicalis)
PPi [cytosol]
Signal Transduction (Xenopus tropicalis)
Intracellular signaling by second messengers (Xenopus tropicalis)
DAG and IP3 signaling (Xenopus tropicalis)
CaM pathway (Xenopus tropicalis)
Calmodulin induced events (Xenopus tropicalis)
PKA-mediated phosphorylation of CREB (Xenopus tropicalis)
PKA activation (Xenopus tropicalis)
Adenylate cyclase produces cAMP (Xenopus tropicalis)
PPi [cytosol]
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Opioid Signalling (Xenopus tropicalis)
G-protein mediated events (Xenopus tropicalis)
Adenylate cyclase activating pathway (Xenopus tropicalis)
Adenylate cyclase converts ATP into cyclic AMP (Xenopus tropicalis)
PPi [cytosol]
PLC beta mediated events (Xenopus tropicalis)
Ca-dependent events (Xenopus tropicalis)
CaM pathway (Xenopus tropicalis)
Calmodulin induced events (Xenopus tropicalis)
PKA-mediated phosphorylation of CREB (Xenopus tropicalis)
PKA activation (Xenopus tropicalis)
Adenylate cyclase produces cAMP (Xenopus tropicalis)
PPi [cytosol]
Signaling by Hedgehog (Xenopus tropicalis)
Hedgehog 'off' state (Xenopus tropicalis)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Xenopus tropicalis)
PPi [cytosol]
Transport of small molecules (Xenopus tropicalis)
Miscellaneous transport and binding events (Xenopus tropicalis)
ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)
PPi [cytosol]
External Reference Information
External Reference
diphosphate(3-) [ChEBI:33019]
Participates
as an input of
ANKH transports PPi from cytosol to extracellular region (Gallus gallus)
ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)
ANKH transports PPi from cytosol to extracellular region (Danio rerio)
ANKH transports PPi from cytosol to extracellular region (Sus scrofa)
ANKH transports PPi from cytosol to extracellular region (Bos taurus)
ANKH transports PPi from cytosol to extracellular region (Canis familiaris)
ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)
ANKH transports PPi from cytosol to extracellular region (Mus musculus)
ANKH transports PPi from cytosol to extracellular region (Homo sapiens)
LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
LHPP:Mg2+ dimer hydrolyses PPi (Gallus gallus)
LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)
LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)
LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)
LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)
LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)
LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)
LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)
as an output of
ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)
Adcy3:Gnal:GTP converts ATP to cAMP (Rattus norvegicus)
FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)
glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol (Mycobacterium tuberculosis)
sulfate is activated to APS (Mycobacterium tuberculosis)
MOD5 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) (Saccharomyces cerevisiae)
TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)
THG1L transfers GMP to 5' end of tRNA(His) (Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)
alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)
proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)
arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)
asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)
glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)
phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)
lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)
glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)
cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)
tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)
threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)
leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)
histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)
RGGT geranylgeranylates RAB proteins (Plasmodium falciparum)
RGGT geranylgeranylates RAB proteins (Saccharomyces cerevisiae)
RGGT geranylgeranylates RAB proteins (Schizosaccharomyces pombe)
RGGT geranylgeranylates RAB proteins (Dictyostelium discoideum)
RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)
RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)
RGGT geranylgeranylates RAB proteins (Danio rerio)
RGGT geranylgeranylates RAB proteins (Bos taurus)
RGGT geranylgeranylates RAB proteins (Canis familiaris)
RGGT geranylgeranylates RAB proteins (Rattus norvegicus)
RGGT geranylgeranylates RAB proteins (Mus musculus)
RGGT geranylgeranylates RAB proteins (Homo sapiens)
Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Mus musculus)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)
UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)
UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)
UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)
UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)
UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)
UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)
UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)
UBA1 adenylates ubiquitin in the cytosol (Mus musculus)
UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Gallus gallus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)
Rap1 signal termination by Rap1GAPs (Dictyostelium discoideum)
Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)
Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)
Rap1 signal termination by Rap1GAPs (Gallus gallus)
Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)
Rap1 signal termination by Rap1GAPs (Danio rerio)
Rap1 signal termination by Rap1GAPs (Sus scrofa)
Rap1 signal termination by Rap1GAPs (Bos taurus)
Rap1 signal termination by Rap1GAPs (Canis familiaris)
Rap1 signal termination by Rap1GAPs (Rattus norvegicus)
Rap1 signal termination by Rap1GAPs (Mus musculus)
Rap1 signal termination by Rap1GAPs (Homo sapiens)
ISGylation of DDX58 (RIG-I) (Dictyostelium discoideum)
ISGylation of DDX58 (RIG-I) (Caenorhabditis elegans)
ISGylation of DDX58 (RIG-I) (Sus scrofa)
ISGylation of DDX58 (RIG-I) (Bos taurus)
ISGylation of DDX58 (RIG-I) (Rattus norvegicus)
ISGylation of DDX58 (RIG-I) (Mus musculus)
ISGylation of DDX58 (RIG-I) (Homo sapiens)
Soluble guanylate cyclase converts GTP to cGMP (Rattus norvegicus)
Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Sus scrofa)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)
Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)
FNTA:FNTB transfers FARN to GNGT1 (Caenorhabditis elegans)
FNTA:FNTB transfers FARN to GNGT1 (Drosophila melanogaster)
FNTA:FNTB transfers FARN to GNGT1 (Xenopus tropicalis)
FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)
FNTA:FNTB transfers FARN to GNGT1 (Bos taurus)
FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)
FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)
FNTA:FNTB transfers FARN to GNGT1 (Mus musculus)
GUCYs converts GTP to cGMP (Dictyostelium discoideum)
GUCYs converts GTP to cGMP (Caenorhabditis elegans)
GUCYs converts GTP to cGMP (Drosophila melanogaster)
GUCYs converts GTP to cGMP (Xenopus tropicalis)
GUCYs converts GTP to cGMP (Sus scrofa)
GUCYs converts GTP to cGMP (Bos taurus)
GUCYs converts GTP to cGMP (Canis familiaris)
GUCYs converts GTP to cGMP (Rattus norvegicus)
GUCYs converts GTP to cGMP (Homo sapiens)
GUCYs converts GTP to cGMP (Mus musculus)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
HLCS biotinylates ACACB (Plasmodium falciparum)
HLCS biotinylates ACACB (Saccharomyces cerevisiae)
HLCS biotinylates ACACB (Schizosaccharomyces pombe)
HLCS biotinylates ACACB (Dictyostelium discoideum)
HLCS biotinylates ACACB (Caenorhabditis elegans)
HLCS biotinylates ACACB (Drosophila melanogaster)
HLCS biotinylates ACACB (Xenopus tropicalis)
HLCS biotinylates ACACB (Sus scrofa)
HLCS biotinylates ACACB (Bos taurus)
HLCS biotinylates ACACB (Canis familiaris)
HLCS biotinylates ACACB (Rattus norvegicus)
HLCS biotinylates ACACB (Mus musculus)
HLCS biotinylates ACACB (Homo sapiens)
FLAD1 phosphorylates FMN (Plasmodium falciparum)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Gallus gallus)
FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)
FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
FLAD1 phosphorylates FMN (Danio rerio)
FLAD1 phosphorylates FMN (Sus scrofa)
FLAD1 phosphorylates FMN (Bos taurus)
FLAD1 phosphorylates FMN (Canis familiaris)
FLAD1 phosphorylates FMN (Rattus norvegicus)
FLAD1 phosphorylates FMN (Mus musculus)
FLAD1 phosphorylates FMN (Homo sapiens)
COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)
COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)
COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)
COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)
COASY transfers an adenylyl group from ATP to PPANT (Gallus gallus)
COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)
COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)
COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)
COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)
COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)
COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)
COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)
2xPPCS ligates PPanK with Cys (Plasmodium falciparum)
2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)
2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)
2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)
2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)
2xPPCS ligates PPanK with Cys (Drosophila melanogaster)
2xPPCS ligates PPanK with Cys (Gallus gallus)
2xPPCS ligates PPanK with Cys (Xenopus tropicalis)
2xPPCS ligates PPanK with Cys (Danio rerio)
2xPPCS ligates PPanK with Cys (Sus scrofa)
2xPPCS ligates PPanK with Cys (Bos taurus)
2xPPCS ligates PPanK with Cys (Canis familiaris)
2xPPCS ligates PPanK with Cys (Rattus norvegicus)
2xPPCS ligates PPanK with Cys (Mus musculus)
2xPPCS ligates PPanK with Cys (Homo sapiens)
COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)
Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)
Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)
Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)
Molybdenum ion transfer onto molybdopterin (Gallus gallus)
Molybdenum ion transfer onto molybdopterin (Sus scrofa)
Molybdenum ion transfer onto molybdopterin (Bos taurus)
Molybdenum ion transfer onto molybdopterin (Canis familiaris)
Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)
Molybdenum ion transfer onto molybdopterin (Mus musculus)
Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)
Molybdenum ion transfer onto molybdopterin (Homo sapiens)
Cyclisation of GTP to precursor Z (Dictyostelium discoideum)
Cyclisation of GTP to precursor Z (Caenorhabditis elegans)
Cyclisation of GTP to precursor Z (Drosophila melanogaster)
Cyclisation of GTP to precursor Z (Gallus gallus)
Cyclisation of GTP to precursor Z (Xenopus tropicalis)
Cyclisation of GTP to precursor Z (Sus scrofa)
Cyclisation of GTP to precursor Z (Bos taurus)
Cyclisation of GTP to precursor Z (Canis familiaris)
Cyclisation of GTP to precursor Z (Rattus norvegicus)
Cyclisation of GTP to precursor Z (Mus musculus)
Cyclisation of GTP to precursor Z (Homo sapiens)
HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)
HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)
HLCS biotinylates 6x(PCCA:PCCB) (Gallus gallus)
HLCS biotinylates 6x(PCCA:PCCB) (Xenopus tropicalis)
HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)
HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)
HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)
HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)
HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)
HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)
HLCS biotinylates PC:Mn2+ (Saccharomyces cerevisiae)
HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)
HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)
HLCS biotinylates PC:Mn2+ (Drosophila melanogaster)
HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)
HLCS biotinylates PC:Mn2+ (Sus scrofa)
HLCS biotinylates PC:Mn2+ (Bos taurus)
HLCS biotinylates PC:Mn2+ (Canis familiaris)
HLCS biotinylates PC:Mn2+ (Rattus norvegicus)
HLCS biotinylates PC:Mn2+ (Mus musculus)
HLCS biotinylates PC:Mn2+ (Homo sapiens)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Drosophila melanogaster)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Gallus gallus)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)
HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)
HLCS biotinylates ACACA:Mn2+ (Plasmodium falciparum)
HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)
HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)
HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)
HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)
HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)
HLCS biotinylates ACACA:Mn2+ (Gallus gallus)
HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)
HLCS biotinylates ACACA:Mn2+ (Sus scrofa)
HLCS biotinylates ACACA:Mn2+ (Bos taurus)
HLCS biotinylates ACACA:Mn2+ (Canis familiaris)
HLCS biotinylates ACACA:Mn2+ (Rattus norvegicus)
HLCS biotinylates ACACA:Mn2+ (Mus musculus)
HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
L protein acts as a cap N7 methyltransferase to modify RSV mRNAs (Homo sapiens)
Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)
Defective RpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)
RNAP transcribes Mtb RNA polyanion (Homo sapiens)
Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)
DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)
DPH6 ligates ammonium to diphthine-EEF2 (Schizosaccharomyces pombe)
DPH6 ligates ammonium to diphthine-EEF2 (Dictyostelium discoideum)
DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)
DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)
DPH6 ligates ammonium to diphthine-EEF2 (Gallus gallus)
DPH6 ligates ammonium to diphthine-EEF2 (Xenopus tropicalis)
DPH6 ligates ammonium to diphthine-EEF2 (Sus scrofa)
DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)
DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)
DPH6 ligates ammonium to diphthine-EEF2 (Rattus norvegicus)
DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)
DPH6 ligates ammonium to diphthine-EEF2 (Homo sapiens)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Plasmodium falciparum)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Saccharomyces cerevisiae)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Caenorhabditis elegans)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Gallus gallus)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Danio rerio)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Bos taurus)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Rattus norvegicus)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Plasmodium falciparum)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Saccharomyces cerevisiae)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Schizosaccharomyces pombe)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Dictyostelium discoideum)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Caenorhabditis elegans)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Drosophila melanogaster)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Danio rerio)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Bos taurus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Rattus norvegicus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Mus musculus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)
nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand) (Homo sapiens)
OAS2 produces oligoadenylates (Homo sapiens)
OAS3 produces oligoadenylates (Homo sapiens)
OAS1 produces oligoadenylates (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Gallus gallus)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Bos taurus)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Canis familiaris)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Mus musculus)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)
NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)
NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)
NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)
NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)
NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)
NADSYN1 hexamer amidates NAAD to NAD+ (Gallus gallus)
NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)
NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)
NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)
NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)
NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Saccharomyces cerevisiae)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Schizosaccharomyces pombe)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Gallus gallus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Sus scrofa)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Gallus gallus)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)
NAMPT transfers PRIB to NAM to form NAMN (Gallus gallus)
NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)
NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)
NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)
NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)
NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)
NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)
NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)
QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
QPRT transfers PRIB to QUIN to form NAMN (Gallus gallus)
QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)
QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)
tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by Mars (Vigna radiata var. radiata)
tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by Mars (Triticum aestivum)
tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)
H2SeO4 is converted to APSe by PAPSS1,2 (Rattus norvegicus)
H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)
SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)
SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)
SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)
SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
SeMet is converted to AdoSeMet by MAT (Gallus gallus)
SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)
SeMet is converted to AdoSeMet by MAT (Danio rerio)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)
SeMet is converted to AdoSeMet by MAT (Mus musculus)
SeMet is converted to AdoSeMet by MAT (Homo sapiens)
SeMet is converted to AdoSeMet by MAT (Sus scrofa)
tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Saccharomyces cerevisiae)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Caenorhabditis elegans)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Drosophila melanogaster)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Gallus gallus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Xenopus tropicalis)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Sus scrofa)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Rattus norvegicus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Mus musculus)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Homo sapiens)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Gallus gallus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)
ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)
ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)
ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)
ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)
ACSL3,4 ligate CoA to AA to form AA-CoA (Gallus gallus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Xenopus tropicalis)
ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)
ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)
ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)
ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Gallus gallus)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Sus scrofa)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Gallus gallus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Xenopus tropicalis)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Gallus gallus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Danio rerio)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)
Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)
Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)
Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)
Reduction of presqualene diphosphate to form squalene (Gallus gallus)
Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)
Reduction of presqualene diphosphate to form squalene (Sus scrofa)
Reduction of presqualene diphosphate to form squalene (Bos taurus)
Reduction of presqualene diphosphate to form squalene (Canis familiaris)
Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)
Reduction of presqualene diphosphate to form squalene (Mus musculus)
Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)
Two FPP molecules dimerize to form presqualene diphosphate (Schizosaccharomyces pombe)
Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)
Two FPP molecules dimerize to form presqualene diphosphate (Gallus gallus)
Two FPP molecules dimerize to form presqualene diphosphate (Xenopus tropicalis)
Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)
Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)
Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)
Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)
Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)
FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)
FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)
FDPS dimer transfers IPPP to GPP (Schizosaccharomyces pombe)
FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)
FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)
FDPS dimer transfers IPPP to GPP (Drosophila melanogaster)
FDPS dimer transfers IPPP to GPP (Gallus gallus)
FDPS dimer transfers IPPP to GPP (Danio rerio)
FDPS dimer transfers IPPP to GPP (Sus scrofa)
FDPS dimer transfers IPPP to GPP (Canis familiaris)
FDPS dimer transfers IPPP to GPP (Rattus norvegicus)
FDPS dimer transfers IPPP to GPP (Mus musculus)
FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)
FDPS dimer transfers IPPP to DMAPP (Saccharomyces cerevisiae)
FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)
FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)
FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)
FDPS dimer transfers IPPP to DMAPP (Drosophila melanogaster)
FDPS dimer transfers IPPP to DMAPP (Gallus gallus)
FDPS dimer transfers IPPP to DMAPP (Danio rerio)
FDPS dimer transfers IPPP to DMAPP (Sus scrofa)
FDPS dimer transfers IPPP to DMAPP (Canis familiaris)
FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)
FDPS dimer transfers IPPP to DMAPP (Mus musculus)
FDPS dimer transfers IPPP to DMAPP (Homo sapiens)
FDPS dimer transfers IPPP to GPP (Homo sapiens)
GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)
GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)
GGPS1 hexamer transfers IPPP to GPP (Drosophila melanogaster)
GGPS1 hexamer transfers IPPP to GPP (Gallus gallus)
GGPS1 hexamer transfers IPPP to GPP (Xenopus tropicalis)
GGPS1 hexamer transfers IPPP to GPP (Sus scrofa)
GGPS1 hexamer transfers IPPP to GPP (Bos taurus)
GGPS1 hexamer transfers IPPP to GPP (Canis familiaris)
GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)
GGPS1 hexamer transfers IPPP to GPP (Mus musculus)
GGPS1 hexamer transfers IPPP to DMAPP (Saccharomyces cerevisiae)
GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)
GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)
GGPS1 hexamer transfers IPPP to DMAPP (Gallus gallus)
GGPS1 hexamer transfers IPPP to DMAPP (Xenopus tropicalis)
GGPS1 hexamer transfers IPPP to DMAPP (Sus scrofa)
GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)
GGPS1 hexamer transfers IPPP to DMAPP (Canis familiaris)
GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)
GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)
GGPS1 hexamer transfers IPPP to DMAPP (Homo sapiens)
GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)
Two FPP molecules dimerize to form presqualene diphosphate (Homo sapiens)
Reduction of presqualene diphosphate to form squalene (Homo sapiens)
Adenylate cyclase converts ATP into cyclic AMP (Dictyostelium discoideum)
Adenylate cyclase converts ATP into cyclic AMP (Caenorhabditis elegans)
Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)
Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)
Adenylate cyclase converts ATP into cyclic AMP (Xenopus tropicalis)
Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)
Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)
Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)
Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)
Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)
Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)
Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Caenorhabditis elegans)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Xenopus tropicalis)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Sus scrofa)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Bos taurus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Canis familiaris)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)
FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Dictyostelium discoideum)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Caenorhabditis elegans)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Drosophila melanogaster)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Gallus gallus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Xenopus tropicalis)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Danio rerio)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Sus scrofa)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Bos taurus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Canis familiaris)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Rattus norvegicus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Mus musculus)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Homo sapiens)
GMPPB converts Mannose-1-phosphate to GDP-Mannose (Schizosaccharomyces pombe)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Plasmodium falciparum)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Xenopus tropicalis)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Danio rerio)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Bos taurus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Canis familiaris)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Rattus norvegicus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Mus musculus)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)
Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)
Dctpp1 hydrolyses 5idCTP (Mus musculus)
DCTPP1 hydrolyses 5idCTP (Homo sapiens)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Gallus gallus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Drosophila melanogaster)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Gallus gallus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Homo sapiens)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Gallus gallus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Gallus gallus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Drosophila melanogaster)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Gallus gallus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Sus scrofa)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Bos taurus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)
UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Schizosaccharomyces pombe)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Gallus gallus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
ITPA hydrolyses XTP to XMP (Plasmodium falciparum)
ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)
ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
ITPA hydrolyses XTP to XMP (Gallus gallus)
ITPA hydrolyses XTP to XMP (Xenopus tropicalis)
ITPA hydrolyses XTP to XMP (Danio rerio)
ITPA hydrolyses XTP to XMP (Sus scrofa)
ITPA hydrolyses XTP to XMP (Bos taurus)
ITPA hydrolyses XTP to XMP (Canis familiaris)
ITPA hydrolyses XTP to XMP (Rattus norvegicus)
ITPA hydrolyses XTP to XMP (Mus musculus)
ITPA hydrolyses XTP to XMP (Homo sapiens)
ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Plasmodium falciparum)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)
ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)
ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)
ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
ITPA hydrolyses dITP to dIMP (Gallus gallus)
ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)
ITPA hydrolyses dITP to dIMP (Danio rerio)
ITPA hydrolyses dITP to dIMP (Sus scrofa)
ITPA hydrolyses dITP to dIMP (Bos taurus)
ITPA hydrolyses dITP to dIMP (Canis familiaris)
ITPA hydrolyses dITP to dIMP (Rattus norvegicus)
ITPA hydrolyses dITP to dIMP (Mus musculus)
ITPA hydrolyses dITP to dIMP (Homo sapiens)
ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)
ITPA hydrolyses ITP to IMP (Plasmodium falciparum)
ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)
ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
ITPA hydrolyses ITP to IMP (Gallus gallus)
ITPA hydrolyses ITP to IMP (Xenopus tropicalis)
ITPA hydrolyses ITP to IMP (Danio rerio)
ITPA hydrolyses ITP to IMP (Sus scrofa)
ITPA hydrolyses ITP to IMP (Bos taurus)
ITPA hydrolyses ITP to IMP (Canis familiaris)
ITPA hydrolyses ITP to IMP (Rattus norvegicus)
ITPA hydrolyses ITP to IMP (Mus musculus)
ITPA hydrolyses ITP to IMP (Homo sapiens)
ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)
APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)
APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)
APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)
APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)
APRT catalyzes the conversion of adenine to AMP (Gallus gallus)
APRT catalyzes the conversion of adenine to AMP (Xenopus tropicalis)
APRT catalyzes the conversion of adenine to AMP (Danio rerio)
APRT catalyzes the conversion of adenine to AMP (Sus scrofa)
APRT catalyzes the conversion of adenine to AMP (Bos taurus)
APRT catalyzes the conversion of adenine to AMP (Canis familiaris)
APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)
APRT catalyzes the conversion of adenine to AMP (Mus musculus)
APRT catalyzes the conversion of adenine to AMP (Homo sapiens)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Gallus gallus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)
SRXN1 reduces hyperoxidized PRDX1 dimer (Saccharomyces cerevisiae)
SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)
SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)
SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)
SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)
SRXN1 reduces hyperoxidized PRDX1 dimer (Rattus norvegicus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)
ISGylation of host proteins (Dictyostelium discoideum)
ISGylation of host proteins (Caenorhabditis elegans)
ISGylation of host proteins (Drosophila melanogaster)
ISGylation of host proteins (Sus scrofa)
ISGylation of host proteins (Bos taurus)
ISGylation of host proteins (Rattus norvegicus)
ISGylation of host proteins (Mus musculus)
ISGylation of host proteins (Homo sapiens)
ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)
ISGylation of protein phosphatase 1 beta (PP2CB) (Drosophila melanogaster)
ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)
ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)
ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)
ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)
ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
ISGylation of E2 conjugating enzymes (Dictyostelium discoideum)
ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)
ISGylation of E2 conjugating enzymes (Drosophila melanogaster)
ISGylation of E2 conjugating enzymes (Sus scrofa)
ISGylation of E2 conjugating enzymes (Bos taurus)
ISGylation of E2 conjugating enzymes (Rattus norvegicus)
ISGylation of E2 conjugating enzymes (Mus musculus)
ISGylation of E2 conjugating enzymes (Homo sapiens)
ISGylation of host protein filamin B (Dictyostelium discoideum)
ISGylation of host protein filamin B (Caenorhabditis elegans)
ISGylation of host protein filamin B (Drosophila melanogaster)
ISGylation of host protein filamin B (Sus scrofa)
ISGylation of host protein filamin B (Bos taurus)
ISGylation of host protein filamin B (Rattus norvegicus)
ISGylation of host protein filamin B (Mus musculus)
ISGylation of host protein filamin B (Homo sapiens)
ISGylation of viral protein NS1 (Homo sapiens)
ISGylation of PKR (Caenorhabditis elegans)
ISGylation of PKR (Drosophila melanogaster)
ISGylation of PKR (Sus scrofa)
ISGylation of PKR (Bos taurus)
ISGylation of PKR (Rattus norvegicus)
ISGylation of PKR (Mus musculus)
ISGylation of PKR (Homo sapiens)
methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)
cGAS produces cyclic GMP-AMP (Homo sapiens)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)
MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Xenopus tropicalis)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Danio rerio)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)
Tut4,Tut7 oligouridylate mRNA (Mus musculus)
TUT4,TUT7 oligouridylate mRNA (Homo sapiens)
K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)
K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)
K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)
TRAF6 oligomer autoubiquitinates (Sus scrofa)
TRAF6 oligomer autoubiquitinates (Canis familiaris)
TRAF6 oligomer autoubiquitinates (Mus musculus)
TRAF6 oligomer autoubiquitinates (Homo sapiens)
K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)
Auto-ubiquitination of TRAF6 (Sus scrofa)
Auto-ubiquitination of TRAF6 (Canis familiaris)
Auto-ubiquitination of TRAF6 (Mus musculus)
Auto-ubiquitination of TRAF6 (Homo sapiens)
pro-RAS proteins are farnesylated (Caenorhabditis elegans)
pro-RAS proteins are farnesylated (Drosophila melanogaster)
pro-RAS proteins are farnesylated (Gallus gallus)
pro-RAS proteins are farnesylated (Danio rerio)
pro-RAS proteins are farnesylated (Bos taurus)
pro-RAS proteins are farnesylated (Rattus norvegicus)
pro-RAS proteins are farnesylated (Homo sapiens)
pro-RAS proteins are farnesylated (Mus musculus)
ISGylation of BECN1 (Homo sapiens)
Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs (Homo sapiens)
ISGylation of IRF3 (Sus scrofa)
ISGylation of IRF3 (Bos taurus)
ISGylation of IRF3 (Rattus norvegicus)
ISGylation of IRF3 (Mus musculus)
Activation of ISG15 by UBA7 E1 ligase (Plasmodium falciparum)
Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)
Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)
Activation of ISG15 by UBA7 E1 ligase (Drosophila melanogaster)
Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)
Activation of ISG15 by UBA7 E1 ligase (Bos taurus)
Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)
Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)
Activation of ISG15 by UBA7 E1 ligase (Mus musculus)
Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)
ISGylation of IRF3 (Homo sapiens)
Polyubiquitination of substrate (Plasmodium falciparum)
Polyubiquitination of substrate (Saccharomyces cerevisiae)
Polyubiquitination of substrate (Schizosaccharomyces pombe)
Polyubiquitination of substrate (Dictyostelium discoideum)
Polyubiquitination of substrate (Caenorhabditis elegans)
Polyubiquitination of substrate (Drosophila melanogaster)
Polyubiquitination of substrate (Gallus gallus)
Polyubiquitination of substrate (Xenopus tropicalis)
Polyubiquitination of substrate (Danio rerio)
Polyubiquitination of substrate (Sus scrofa)
Polyubiquitination of substrate (Bos taurus)
Polyubiquitination of substrate (Canis familiaris)
Polyubiquitination of substrate (Rattus norvegicus)
Polyubiquitination of substrate (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Plasmodium falciparum)
Transfer of Ub from E2 to substrate and release of E2 (Saccharomyces cerevisiae)
Transfer of Ub from E2 to substrate and release of E2 (Schizosaccharomyces pombe)
Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)
Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
E1 mediated ubiquitin activation (Plasmodium falciparum)
E1 mediated ubiquitin activation (Saccharomyces cerevisiae)
E1 mediated ubiquitin activation (Schizosaccharomyces pombe)
E1 mediated ubiquitin activation (Dictyostelium discoideum)
E1 mediated ubiquitin activation (Caenorhabditis elegans)
E1 mediated ubiquitin activation (Drosophila melanogaster)
E1 mediated ubiquitin activation (Gallus gallus)
E1 mediated ubiquitin activation (Xenopus tropicalis)
E1 mediated ubiquitin activation (Danio rerio)
E1 mediated ubiquitin activation (Sus scrofa)
E1 mediated ubiquitin activation (Bos taurus)
E1 mediated ubiquitin activation (Canis familiaris)
E1 mediated ubiquitin activation (Rattus norvegicus)
E1 mediated ubiquitin activation (Mus musculus)
E1 mediated ubiquitin activation (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)
nsp12 guanylates nsp7 (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) (Homo sapiens)
nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)
nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
nsp8 generates RNA primers (Homo sapiens)
nsp8 generates RNA primers (Homo sapiens)
nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)
RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)
Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)
Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)
nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)
Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)
Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)
Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)
Dephosphorylation of phospho-Cdh1 (Danio rerio)
Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)
Dephosphorylation of phospho-Cdh1 (Gallus gallus)
Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)
Dephosphorylation of phospho-Cdh1 (Sus scrofa)
Dephosphorylation of phospho-Cdh1 (Bos taurus)
Dephosphorylation of phospho-Cdh1 (Canis familiaris)
Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)
Dephosphorylation of phospho-Cdh1 (Mus musculus)
Calmodulin-activated adenylate cyclases Adcy1 and Adcy8 generate cAMP (Rattus norvegicus)
Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)
Adenylate cyclase produces cAMP (Dictyostelium discoideum)
Adenylate cyclase produces cAMP (Caenorhabditis elegans)
Adenylate cyclase produces cAMP (Drosophila melanogaster)
Adenylate cyclase produces cAMP (Gallus gallus)
Adenylate cyclase produces cAMP (Xenopus tropicalis)
Adenylate cyclase produces cAMP (Danio rerio)
Adenylate cyclase produces cAMP (Sus scrofa)
Adenylate cyclase produces cAMP (Bos taurus)
Adenylate cyclase produces cAMP (Canis familiaris)
Adenylate cyclase produces cAMP (Rattus norvegicus)
Adenylate cyclase produces cAMP (Mus musculus)
Adenylate cyclase produces cAMP (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Canis familiaris)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
Dephosphorylation of phospho-Cdh1 (Homo sapiens)
PA is converted to CDP-DAG by CDS1 (Homo sapiens)
PA is converted to CDP-DAG by CDS1 (Mus musculus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)
PA is converted to CDP-DAG by CDS1 (Bos taurus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)
PA is converted to CDP-DAG by CDS1 (Sus scrofa)
PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)
PA is converted to CDP-DAG by CDS1 (Canis familiaris)
PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Gallus gallus)
PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)
PA is converted to CDP-DAG by CDS1 (Caenorhabditis elegans)
PA is converted to CDP-DAG by CDS1 (Dictyostelium discoideum)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)
PA is converted to CDP-DAG by CDS1 (Schizosaccharomyces pombe)
PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)
PA is converted to CDP-DAG by CDS1 (Plasmodium falciparum)
PETA and CTP are condensed to CDP-ETA by PCY2 (Homo sapiens)
PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)
PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)
PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)
PETA and CTP are condensed to CDP-ETA by PCY2 (Xenopus tropicalis)
PETA and CTP are condensed to CDP-ETA by PCY2 (Gallus gallus)
PETA and CTP are condensed to CDP-ETA by PCY2 (Drosophila melanogaster)
PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)
PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)
PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)
PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)
PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)
PA is converted to CDP-DAG by CDS1 (Gallus gallus)
Other forms of this molecule
PPi [endoplasmic reticulum membrane]
PPi [platelet dense granule lumen]
PPi [endoplasmic reticulum lumen]
PPi [extracellular region]
PPi [peroxisomal matrix]
PPi [mitochondrial matrix]
PPi [nucleoplasm]
Cross References
AraCyc
PPI
CAS
2466-09-3
,
09/03/2466
ChEBI
33019
COMPOUND
C00013
,
C00013
PubChem Compound
4097574
,
1023
ZINC
ZINC000006827695
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