NADSYN1 hexamer amidates NAAD to NAD+

Stable Identifier
R-HSA-197271
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
deamido-NAD(+) + L-glutamine + ATP + H2O => L-glutamate + AMP + diphosphate + NAD(+) + H(+), Amidation of deamino-NAD+ to NAD+
ReviewStatus
5/5
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Cytosolic hexameric NAD synthase 1 (NADSYN1) catalyses the final step in the biosynthesis of NAD+, both in de novo synthesis and in the salvage pathway. The enzymes makes use of an amide donor in the reaction (Hara et al. 2003).
Literature References
PubMed ID Title Journal Year
12547821 Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.

Yamada, K, Terashima, M, Shimoyama, M, Osago, H, Hara, N, Tsuchiya, M

J Biol Chem 2003
Participants
Participates
Event Information
Catalyst Activity

NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]

Orthologous Events
Cross References
RHEA
Rhea
Authored
Reviewed
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