Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)

Stable Identifier
R-HSA-159425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cholate or chenodeoxycholate, coenzyme A, and ATP react to form their CoA conjugates, AMP, pyrophosphate and water. This reaction is catalyzed by SLC27A5 (BACS) associated with the endoplasmic reticulum membrane, but the substrates and products are cytosolic (Mihalik et al. 2002).

Literature References
PubMed ID Title Journal Year
11980911 Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling

Mihalik, SJ, Steinberg, SJ, Pei, Z, Park, J, Kim, DG, Heinzer, AK, Dacremont, G, Wanders, RJ, Cuebas, DA, Smith, KD, Watkins, PA

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
long-chain fatty acid-CoA ligase activity of SLC27A5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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