Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)

Stable Identifier
R-HSA-159425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
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Cholate or chenodeoxycholate, coenzyme A, and ATP react to form their CoA conjugates, AMP, pyrophosphate and water. This reaction is catalyzed by SLC27A5 (BACS) associated with the endoplasmic reticulum membrane, but the substrates and products are cytosolic (Mihalik et al. 2002).
Literature References
PubMed ID Title Journal Year
11980911 Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling

Mihalik, SJ, Steinberg, SJ, Pei, Z, Park, J, Kim, DG, Heinzer, AK, Dacremont, G, Wanders, RJA, Cuebas, DA, Smith, KD, Watkins, PA

J Biol Chem 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

long-chain fatty acid-CoA ligase activity of SLC27A5 [endoplasmic reticulum membrane]

Physical Entity
SLC27A5 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
long-chain fatty acid-CoA ligase activity (GO:0004467)
Orthologous Events
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2005-03-09)
Reviewed
D'Eustachio, P  (2007-04-30)
Created
Jassal, B  (2005-03-09)
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