RNAP transcribes Mtb RNA polyanion

Stable Identifier
R-HSA-9697085
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
Synonyms
DNA-directed RNA polymerase transcribes RNA polyanion
ReviewStatus
5/5
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RNAP transcribes Mtb RNA polyanion
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The Mtb RNA polymerase core complex consists of 5 subunits (2α:β:β':ω) and elongates transcribed RNA polyanion by the step-wise attachment of ribonucleoside triphosphates, according to the DNA template (Hu et al. 2012).
Literature References
PubMed ID Title Journal Year
22570422 Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the σ A-containing RNA polymerase holoenzyme

Morichaud, Z, Hu, Y, Brodolin, K, Leonetti, JP, Chen, S

Nucleic Acids Res. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNAP [cytosol]

Physical Entity
RNAP [cytosol] (Mycobacterium tuberculosis)
Activity
DNA-directed 5'-3' RNA polymerase activity (GO:0003899)
This event is regulated
Negatively by
Regulator
RNAP:rifampicin [cytosol] (Mycobacterium tuberculosis)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-03-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Jassal, B  (2020-08-05)
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