Reactome | pro-RAS proteins are farnesylated

pro-RAS proteins are farnesylated

Stable Identifier

R-HSA-9647978

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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RAS proteins are isoprenylated at a CaaX motif in the hypervariable region, where a is an aliphatic amino acid and X is any amino acid (Casey et al, 1989; Dharmaiah et al, 2016; reviewed in Ahean et al, 2018). Geranylgeranylation is favoured when X is leucine, while all other amino acids at this position favour farnesylation by farnesyltransferase (Casey et al, 1989; Reid et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
15451670	Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity Casey, PJ, Reid, TS, Beese, LS, Terry, KL	J. Mol. Biol.	2004
2682646	p21ras is modified by a farnesyl isoprenoid Der, CJ, Solski, PA, Casey, PJ, Buss, JE	Proc. Natl. Acad. Sci. U.S.A.	1989
27791178	Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ Dharmaiah, S, Bindu, L, Ghirlando, R, Frank, PH, McCormick, F, Gillette, WK, Tran, TH, Stephen, AG, Nissley, DV, Esposito, D, Simanshu, DK	Proc. Natl. Acad. Sci. U.S.A.	2016
29311131	Posttranslational Modifications of RAS Proteins Philips, MR, Zhou, M, Ahearn, I	Cold Spring Harb Perspect Med	2018