sulfate is activated to APS

Stable Identifier
R-MTU-936729
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Sufate is first activated by adding it to ATP, giving APS. Although both sulfate adenylyltransferase and APS kinase activities reside in the same enzyme complex, the intermediate APS is not channeled within the complex. Its accessibility ensures the functionality of the cysteine biosynthetic pathway (Pinto et al, 2004; Sun et al, 2005).

Literature References
PubMed ID Title Journal Year
15615729 The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis

Liu, S, Triccas, JA, Leyh, TS, Andreassi JL, 2nd, Pinto, R, Sun, M

J Biol Chem 2005
15184554 The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex

Tang, QX, Britton, WJ, Triccas, JA, Leyh, TS, Pinto, R

Microbiology 2004
Participants
Participates
Catalyst Activity

sulfate adenylyltransferase (ATP) activity of sulfate adenylyltransferase complex [cytosol]

Authored
Reviewed
Created
Cite Us!