Reactome | NAMPT transfers PRIB to NAM to form NAMN

NAMPT transfers PRIB to NAM to form NAMN

Stable Identifier

R-HSA-197250

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+) => beta-nicotinamide D-ribonucleotide + diphosphate, Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN)

ReviewStatus

5/5

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NAMPT transfers PRIB to NAM to form NAMN

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Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the condensation of nicotinamide (NAM) with 5- phosphoribosyl-1-pyrophosphate (PRPP) to yield nicotinamide D-ribonucleotide (NMN), an intermediate in the biosynthesis of NAD. This reaction is the rate limiting component in the mammalian NAD biosynthesis pathway. The ability of cloned human NAMPT (Samal et al. 1994) to catalyze this reaction has not been determined; it is inferred from the properties of the better-studied mouse ortholog (Revollo et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
8289818	Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor Samal, B, Sun, Y, Stearns, G, Xie, C, Suggs, S, McNiece, I	Mol Cell Biol	1994
15381699	The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells Revollo, JR, Grimm, AA, Imai, S	J Biol Chem	2004