NAMPT transfers PRIB to NAM to form NAMN

Stable Identifier
R-HSA-197250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN)
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NAMPT transfers PRIB to NAM to form NAMN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nicotinamide phosphoribosyltransferase (NamPRT) catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide D-ribonucleotide (NMN), an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway.
Literature References
PubMed ID Title Journal Year
8289818 Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor

Suggs, S, McNiece, I, Stearns, G, Samal, B, Sun, Y, Xie, C

Mol Cell Biol 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

nicotinamide phosphoribosyltransferase activity of NAMPT [cytosol]

Physical Entity
NAMPT [cytosol] (Homo sapiens)
Activity
nicotinamide phosphoribosyltransferase activity (GO:0047280)
Orthologous Events
NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)
NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)
NAMPT transfers PRIB to NAM to form NAMN (Gallus gallus)
NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)
NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)
NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)
NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)
Authored
Jassal, B  (2007-05-02)
Created
Jassal, B  (2007-05-02)
Cite Us!