NAMPT transfers PRIB to NAM to form NAMN

Stable Identifier
R-HSA-197250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN)
Locations in the PathwayBrowser
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Nicotinamide phosphoribosyltransferase (NamPRT) catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide D-ribonucleotide (NMN), an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway.

Literature References
PubMed ID Title Journal Year
8289818 Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor

Samal, B, Sun, Y, Stearns, G, Xie, C, Suggs, S, McNiece, I

Mol Cell Biol 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nicotinamide phosphoribosyltransferase activity of NAMPT [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created