Reactome | GMPS dimer transforms 6TXMP to 6TGMP

GMPS dimer transforms 6TXMP to 6TGMP

Stable Identifier

R-HSA-9748957

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

6TXMP--GMPS-->6TGMP

ReviewStatus

5/5

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GMP synthase (glutamine-hydrolyzing) (GMPS) is involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP for cellular processes. GMPS forms a dimer and can act on many drugs that are nucleobase- and nucleoside-based compounds (Welin et al. 2013). Here, 6-thioxanthosine 5'-monophosphate (6TXMP) is transformed to 6-thioguanosine monophosphate (6TGMP), the first 6-thioguanine nucleotide (6-TGN).

Literature References

PubMed ID	Title	Journal	Year
23816837	Substrate specificity and oligomerization of human GMP synthetase Johansson, A, Hammarström, M, Nordlund, P, Lehtiö, L, Welin, M, Flodin, S, Nyman, T, Trésaugues, L, Graslund, S	J Mol Biol	2013