HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

Stable Identifier
R-HSA-74215
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)
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Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).

Literature References
PubMed ID Title Journal Year
6300847 Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

Bohlen, P, Esty, AC, Jolly, DJ, Hunkapillar, T, Johnson, GG, Berg, P, Friedmann, T, Filpula, D, Shively, JE, Okayama, H

Proc Natl Acad Sci U S A 1983
Participants
Participates
Catalyst Activity

purine phosphoribosyltransferase activity of HPRT1 tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Created
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