Reactome | ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

Stable Identifier

R-HSA-5695957

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

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Long-chain fatty acid-CoA ligases 1 and 2 (ACSBG1 and 2) are capable of activating very long-chain fatty acids (VLCFA) and are thought to play a role in fatty acid metabolism in the brain (ACSBG1 and 2) (Steinberg et al. 2000, Pei et al. 2003), and testes (ACSBG2) (Pei et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16371355	The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase Watkins, PA, Jia, Z, Pei, Z	J. Biol. Chem.	2006
10954726	Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids Steinberg, SJ, Morgenthaler, J, Watkins, PA, Smith, KD, Heinzer, AK	J. Biol. Chem.	2000
12975357	The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. Li, Y, Smith, KD, Zuidervaart, MM, Watkins, PA, Jia, Z, Oey, NA, Pei, Z, Steinberg, SJ	J. Biol. Chem.	2003