ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Long-chain fatty acid-CoA ligases 1 and 2 (ACSBG1 and 2) are capable of activating very long-chain fatty acids (VLCFA) and are thought to play a role in fatty acid metabolism in the brain (ACSBG1 and 2) (Steinberg et al. 2000, Pei et al. 2003), and testes (ACSBG2) (Pei et al. 2006).

Literature References
PubMed ID Title Journal Year
16371355 The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase

Watkins, PA, Jia, Z, Pei, Z

J. Biol. Chem. 2006
10954726 Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids

Steinberg, SJ, Morgenthaler, J, Watkins, PA, Smith, KD, Heinzer, AK

J. Biol. Chem. 2000
12975357 The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.

Li, Y, Smith, KD, Zuidervaart, MM, Watkins, PA, Jia, Z, Oey, NA, Pei, Z, Steinberg, SJ

J. Biol. Chem. 2003
Catalyst Activity

very long-chain fatty acid-CoA ligase activity of ACSBG1,2 [cytosol]

Orthologous Events
Cite Us!