ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

Stable Identifier
R-HSA-5695957
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Long-chain fatty acid-CoA ligases 1 and 2 (ACSBG1 and 2) are capable of activating very long-chain fatty acids (VLCFA) and are thought to play a role in fatty acid metabolism in the brain (ACSBG1 and 2) (Steinberg et al. 2000, Pei et al. 2003), and testes (ACSBG2) (Pei et al. 2006).

Literature References
PubMed ID Title Journal Year
10954726 Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids

Steinberg, SJ, Morgenthaler, J, Heinzer, AK, Smith, KD, Watkins, PA

J. Biol. Chem. 2000
16371355 The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase

Pei, Z, Jia, Z, Watkins, PA

J. Biol. Chem. 2006
12975357 The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.

Pei, Z, Oey, NA, Zuidervaart, MM, Jia, Z, Li, Y, Steinberg, SJ, Smith, KD, Watkins, PA

J. Biol. Chem. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
very long-chain fatty acid-CoA ligase activity of ACSBG1,2 [cytosol]
Physical Entity
Activity
Orthologous Events
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