Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs

Stable Identifier
Reaction [uncertain]
Homo sapiens
Related Species
Human SARS coronavirus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
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SARS-CoV-1 encodes eight subgenomic RNAs, mRNA2 to mRNA9. mRNA1 corresponds to the genomic RNA. mRNA2 encodes the S protein. mRNA3 is bicistronic and encodes proteins 3a and 3b. mRNA4 encodes the E protein. mRNA5 encodes the M protein. mRNA6 encodes the protein 6. mRNA7, mRNA8 and mRNA9 are bicistronic, with mRNA7 encoding proteins 7a and 7b, mRNA8 encoding proteins 8a and 8b, and mRNA 9 encoding proteins 9a and N. The 5' and 3' ends of subgenomic RNAs are identical, in accordance with the template switch model of coronavirus RNA transcription (Snijder et al. 2003, Thiel et al. 2003, Yount et al. 2003). Based on studies of the murine hepatitis virus (MHV), which is closely related to SARS-CoV-1, positive-sense virus mRNAs are present at much higher amounts than negative-sense mRNAs (Irigoyen et al. 2016).
Literature References
PubMed ID Title Journal Year
12917450 Mechanisms and enzymes involved in SARS coronavirus genome expression

Rabenau, H, Schelle, B, Hertzig, T, Ivanov, KA, Gorbalenya, AE, Putics, Á, Bayer, S, Ziebuhr, J, Thiel, V, Doerr, HW, Weißbrich, B, Snijder, EJ

J. Gen. Virol. 2003
12927536 Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage

Bredenbeek, PJ, Gorbalenya, AE, Rozanov, M, Spaan, WJ, Ziebuhr, J, Thiel, V, Guan, Y, Dobbe, JC, Snijder, EJ, Poon, LL

J. Mol. Biol. 2003
14569023 Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

Fritz, EA, Geisbert, TW, Prentice, E, Hensley, LE, Denison, MR, Jahrling, PB, Yount, B, Curtis, KM, Baric, RS

Proc. Natl. Acad. Sci. U.S.A. 2003
Catalyst Activity

RNA-directed 5'-3' RNA polymerase activity of SARS-CoV-1 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]

Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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