COASY transfers an adenylyl group from ATP to PPANT

Stable Identifier
R-HSA-196754
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Adenylation of phosphopantetheine
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The adenylyl transferase activity of bifunctional coenzyme A synthase (COASY) catalyzes the transfer of an adenylyl group from ATP to pantetheinephosphate (PPANT) to form dephospho-Coenzyme A (DP-CoA) (Daugherty et al. 2002). The enzyme is associated with the mitochondrial outer membrane (Zhyvoloup et al. 2003).

Literature References
PubMed ID Title Journal Year
11994049 Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)

Aghajanian, S, Worrall, DM

Biochem J 2002
14514684 Subcellular localization and regulation of coenzyme A synthase

Zhyvoloup, A, Nemazanyy, I, Panasyuk, G, Valovka, T, Fenton, T, Rebholz, H, Wang, ML, Foxon, R, Lyzogubov, V, Usenko, V, Kyyamova, R, Gorbenko, O, Matsuka, G, Filonenko, V, Gout, IT

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
pantetheine-phosphate adenylyltransferase activity of COASY [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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