Reactome | PETA and CTP are condensed to CDP-ETA by PCY2

PETA and CTP are condensed to CDP-ETA by PCY2

Stable Identifier

R-HSA-1483190

Type

Reaction

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Locations in the PathwayBrowser

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PETA and CTP are condensed to CDP-ETA by PCY2

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At the endoplasmic reticulum (ER) membrane, active membrane-bound ethanolamine-phosphate cytidylyltransferase (PCY2) dimer condenses phosphoethanolamine (PETA) and cytidine triphosphate (CTP) to produce CDP-ethanolamine (CDP-ETA) (Zhu et al. 2008, Nakashima et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9083101	Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant Hosaka, K, Nikawa, J, Nakashima, A	J Biol Chem	1997
18583706	Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1 Johnson, C, Bakovic, M, Zhu, L	J Lipid Res	2008

Participants

Input

Output

Participates

as an event of

Synthesis of PE (Homo sapiens)

Catalyst Activity

ethanolamine-phosphate cytidylyltransferase activity of PCYT2 dimer [endoplasmic reticulum membrane]

Physical Entity

PCYT2 dimer [endoplasmic reticulum membrane] (Homo sapiens)

Activity

ethanolamine-phosphate cytidylyltransferase activity (GO:0004306)

Orthologous Events

PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)

PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)

PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)

PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)

PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)

PETA and CTP are condensed to CDP-ETA by PCY2 (Drosophila melanogaster)

PETA and CTP are condensed to CDP-ETA by PCY2 (Gallus gallus)

PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)

PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)

PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)

PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)

PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)

PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)

PETA and CTP are condensed to CDP-ETA by PCY2 (Xenopus tropicalis)

Cross References

Rhea

24593

Authored

Williams, MG (2011-09-14)

Created

Williams, MG (2011-08-12)

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