Activated Adenylyl cyclase synthesizes cyclic AMP

Stable Identifier
R-HSA-381607
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
ATP => 3',5'-cyclic AMP + diphosphate
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated Adenylyl cyclase synthesizes cyclic AMP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated adenylyl cyclase catalyzes the conversion of one molecule of ATP to one molecule of 3',5'-cyclic AMP (cAMP) and one molecule of pyrophosphate.
Literature References
PubMed ID Title Journal Year
7589461 Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

Gromada, J, Rorsman, P, Dissing, S, Wulff, BS

FEBS Lett 1995
10318832 cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

Holz, GG, Leech, CA, Heller, RS, Castonguay, M, Habener, JF

J Biol Chem 1999
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Gromada, J, Brock, B, Schmitz, O, Rorsman, P

Basic Clin Pharmacol Toxicol 2004
13680124 Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1

Delmeire, D, Flamez, D, Hinke, SA, Cali, JJ, Pipeleers, D, Schuit, F

Diabetologia 2003
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Tesmer, JJ, Sunahara, RK, Gilman, AG, Sprang, SR

Science 1997
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, ME, Egan, JM

Pharmacol Ther 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

adenylate cyclase activity of ADCY5,6,8:G-alpha(s):GTP [plasma membrane]

Physical Entity
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
Activity
adenylate cyclase activity (GO:0004016)
Cross References
RHEA
Authored
May, B  (2009-05-28)
Reviewed
Gillespie, ME  (2009-06-02)
Created
May, B  (2008-11-20)
Cite Us!