Activated Adenylyl cyclase synthesizes cyclic AMP

Stable Identifier
Reaction [transition]
Homo sapiens
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Activated adenylyl cyclase catalyzes the conversion of one molecule of ATP to one molecule of 3',5'-cyclic AMP (cAMP) and one molecule of pyrophosphate.

Literature References
PubMed ID Title Journal Year
10318832 cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

Holz, GG, Leech, CA, Heller, RS, Castonguay, M, Habener, JF

J Biol Chem 1999
7589461 Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

Gromada, J, Rorsman, P, Dissing, S, Wulff, BS

FEBS Lett 1995
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Gromada, J, Brock, B, Schmitz, O, Rorsman, P

Basic Clin Pharmacol Toxicol 2004
13680124 Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1

Delmeire, D, Flamez, D, Hinke, SA, Cali, JJ, Pipeleers, D, Schuit, F

Diabetologia 2003
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Tesmer, JJ, Sunahara, RK, Gilman, AG, Sprang, SR

Science 1997
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, ME, Egan, JM

Pharmacol Ther 2007
Catalyst Activity

adenylate cyclase activity of ADCY5,6,8:G-alpha(s):GTP [plasma membrane]

Cross References
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