Activated Adenylyl cyclase synthesizes cyclic AMP

Stable Identifier
R-HSA-381607
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activated Adenylyl cyclase synthesizes cyclic AMP
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Activated adenylyl cyclase catalyzes the conversion of one molecule of ATP to one molecule of 3',5'-cyclic AMP (cAMP) and one molecule of pyrophosphate.
Literature References
PubMed ID Title Journal Year
7589461 Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

Wulff, BS, Gromada, J, Dissing, S, Rorsman, P

FEBS Lett 1995
10318832 cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

Holz, GG, Habener, JF, Heller, RS, Leech, CA, Castonguay, M

J Biol Chem 1999
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Brock, B, Gromada, J, Rorsman, P, Schmitz, O

Basic Clin Pharmacol Toxicol 2004
13680124 Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1

Schuit, F, Delmeire, D, Cali, JJ, Hinke, SA, Pipeleers, D, Flamez, D

Diabetologia 2003
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Sunahara, RK, Tesmer, JJ, Gilman, AG, Sprang, SR

Science 1997
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Egan, JM, Doyle, ME

Pharmacol Ther 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

adenylate cyclase activity of ADCY5,6,8:G-alpha(s):GTP [plasma membrane]

Physical Entity
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
Activity
adenylate cyclase activity (GO:0004016)
Cross References
Rhea
Authored
May, B  (2009-05-28)
Reviewed
Gillespie, ME  (2009-06-02)
Created
May, B  (2008-11-20)
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