aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]

Stable Identifier
R-HSA-70599
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate
ReviewStatus
5/5
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aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
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Cytosolic asparagine synthase (ASNS) catalyzes the reaction of aspartate, glutamine, and ATP to form asparagine, glutamate, AMP, and pyrophosphate. Studies of the recombinant protein expressed in E. coli suggest that the active form of the enzyme is a dimer (Van Heeke and Schuster 1989).
Literature References
PubMed ID Title Journal Year
2564390 Expression of human asparagine synthetase in Escherichia coli

Schuster, SM, Van Heeke, G

J Biol Chem 1989
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Catalyst Activity

asparagine synthase (glutamine-hydrolyzing) activity of ASNS dimer [cytosol]

Physical Entity
ASNS dimer [cytosol] (Homo sapiens)
Activity
asparagine synthase (glutamine-hydrolyzing) activity (GO:0004066)
Orthologous Events
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Gallus gallus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)
Cross References
RHEA
Rhea
Reviewed
D'Eustachio, P  (2024-11-08)
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