methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate

Stable Identifier
R-HSA-379994
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
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MARS (cytosolic methionyl tRNA synthetase) catalyzes the reaction of methionine, tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaminska et al. 2001).
Literature References
PubMed ID Title Journal Year
11714285 The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function

Mirande, M, Kaminska, M, Shalak, V

Biochemistry 2001
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Catalyst Activity

methionine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]

Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Activity
methionine-tRNA ligase activity (GO:0004825)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-07)
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