methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate

Stable Identifier
R-HSA-379994
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MARS (cytosolic methionyl tRNA synthetase) catalyzes the reaction of methionine, tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaminska et al. 2001).
Literature References
PubMed ID Title Journal Year
11714285 The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function

Kaminska, M, Shalak, V, Mirande, M

Biochemistry 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

methionine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]

Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Activity
methionine-tRNA ligase activity (GO:0004825)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-07)
Cite Us!