leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate

Stable Identifier
R-HSA-379974
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LARS (cytosolic leucyl tRNA synthetase) catalyzes the reaction of leucine, tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Ling et al. 2005).

Literature References
PubMed ID Title Journal Year
16055448 The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex

Ling, C, Yao, YN, Zheng, YG, Wei, H, Wang, L, Wu, XF, Wang, ED

J Biol Chem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
leucine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
Physical Entity
Activity
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