leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate

Stable Identifier
R-HSA-379974
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
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LARS (cytosolic leucyl tRNA synthetase) catalyzes the reaction of leucine, tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Ling et al. 2005).
Literature References
PubMed ID Title Journal Year
16055448 The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex

Wang, ED, Ling, C, Wang, L, Wei, H, Zheng, YG, Wu, XF, Yao, YN

J Biol Chem 2005
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Catalyst Activity

leucine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]

Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Activity
leucine-tRNA ligase activity (GO:0004823)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-07)
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