Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP

Stable Identifier
R-HSA-442715
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Based on studies in rat neurons, Ca2+ influx through NMDA receptors in the post-synaptic neuron results in activation of adenylate cyclase (Chetkovich et al. 1991), which is mediated by binding of activated calmodulin (CALM1:4xCa2+) to adenylate cyclase (Chetkovich and Sweatt 1993). Two adenylate cyclase isoforms, ADCY1 (AC1) and ADCY8 (AC8), are activated by calmodulin and involved in NMDA receptor-mediated long term potentiation (LTP), which plays a role in learning and memory (Xia et al. 1991, Cali et al. 1994, Wong et al. 1999, Wei et al. 2002, Nicol et al. 2005, Conti et al. 2007). Activated ADCY1 and ADCY8 produce cAMP, which further activates PKA.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium- and calmodulin-responsive adenylate cyclase activity of ADCY1,ADCY8:CALM1:4xCa2+ [plasma membrane]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Reviewed
Created