FDPS dimer transfers IPPP to DMAPP

Stable Identifier
Reaction [transition]
Homo sapiens
Addition of isopentenyl pyrophosphate to DMAPP
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The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate (IPPP) to DMAPP: farnesyl pyrophosphate synthase dimer (FPPS dimer) and geranylgeranyl pyrophosphate synthetase hexamer (GGPPS hexamer) (Kavanaugh et al, 2006). Both enzymes utlise Mg2+ as cofactor (Chang et al. 2021).

Literature References
PubMed ID Title Journal Year
33246356 Structure, catalysis, and inhibition mechanism of prenyltransferase

Wang, AH, Chang, HY, Cheng, TH

IUBMB Life 2021
9741684 Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression

Edwards, PA, Shell, BK, Greene, JM, Ericsson, J, Florence, C, Carter, KC, Duan, DR

J Lipid Res 1998
16684881 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

Knapp, S, Russell, RG, Guo, K, Oppermann, U, Ebetino, FH, Kavanagh, KL, Dunford, JE, Rogers, MJ, Wu, X

Proc Natl Acad Sci U S A 2006
10026212 Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.

Sagami, I, Kuzuguchi, T, Morita, Y, Sagami, H, Ogura, K

J Biol Chem 1999
Catalyst Activity

dimethylallyltranstransferase activity of holo-FDPS dimer [cytosol]

Orthologous Events
Cross References
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