Reactome | FDPS dimer transfers IPPP to DMAPP

FDPS dimer transfers IPPP to DMAPP

Stable Identifier

R-HSA-191322

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

isopentenyl diphosphate + dimethylallyl diphosphate => (2E)-geranyl diphosphate + diphosphate, Addition of isopentenyl pyrophosphate to DMAPP

ReviewStatus

5/5

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The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate (IPPP) to DMAPP: farnesyl pyrophosphate synthase dimer (FPPS dimer) and geranylgeranyl pyrophosphate synthetase hexamer (GGPPS hexamer) (Kavanaugh et al, 2006). Both enzymes utlise Mg2+ as cofactor (Chang et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
33246356	Structure, catalysis, and inhibition mechanism of prenyltransferase Chang, HY, Cheng, TH, Wang, AH	IUBMB Life	2021
9741684	Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression Ericsson, J, Greene, JM, Carter, KC, Shell, BK, Duan, DR, Florence, C, Edwards, PA	J Lipid Res	1998
16684881	The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Kavanagh, KL, Guo, K, Dunford, JE, Wu, X, Knapp, S, Ebetino, FH, Rogers, MJ, Russell, RG, Oppermann, U	Proc Natl Acad Sci U S A	2006
10026212	Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi, T, Morita, Y, Sagami, I, Sagami, H, Ogura, K	J Biol Chem	1999