phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate

Stable Identifier
R-HSA-379848
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
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FARS (cytosolic phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a heterotetramer of two alpha and two beta subunits (Moor et al. 2002).
Literature References
PubMed ID Title Journal Year
11858721 Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes

Safro, M, Linshiz, G, Moor, N

Protein Expr Purif 2002
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Catalyst Activity

phenylalanine-tRNA ligase activity of FARS A2B2 tetramer [cytosol]

Physical Entity
FARS A2B2 tetramer [cytosol] (Homo sapiens)
Activity
phenylalanine-tRNA ligase activity (GO:0004826)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-06)
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