asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate

Stable Identifier
R-HSA-379996
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
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NARS (cytosolic asparaginyl tRNA synthetase) catalyzes the reaction of asparagine, tRNA(Asn), and ATP to form Asn-tRNA(Asn), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Beaulande et al. 1998).
Literature References
PubMed ID Title Journal Year
9421509 Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen

Beaulande, M, Tarbouriech, N, Hartlein, M

Nucleic Acids Res 1998
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Catalyst Activity

asparagine-tRNA ligase activity of NARS [cytosol]

Physical Entity
NARS [cytosol] (Homo sapiens)
Activity
asparagine-tRNA ligase activity (GO:0004816)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-07)
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