alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate

Stable Identifier
R-HSA-379864
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
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AARS (cytosolic alanyl tRNA synthetase) catalyzes the reaction of alanine, tRNA(ala), and ATP to form Ala tRNA(Ala), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a monomer (Shiba et al. 1995). A mutation in the editing domain of the mouse Aars gene results in misincorporation of non-cognate amino acids into cellular proteins. This is associated with protein misfolding in Purkinje cells and a phenotype consistent with human ataxia (Lee et al. 2006).
Literature References
PubMed ID Title Journal Year
7654687 Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition

Shiba, K, Ripmaster, T, Suzuki, N, Nichols, R, Plotz, P, Noda, T, Schimmel, P

Biochemistry 1995
16906134 Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

Lee, JW, Beebe, K, Nangle, LA, Jang, J, Longo-Guess, CM, Cook, SA, Davisson, MT, Sundberg, JP, Schimmel, P, Ackerman, SL

Nature 2006
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Catalyst Activity

alanine-tRNA ligase activity of AARS [cytosol]

Physical Entity
AARS [cytosol] (Homo sapiens)
Activity
alanine-tRNA ligase activity (GO:0004813)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-06)
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