Reactome | DPH6 ligates ammonium to diphthine-EEF2

DPH6 ligates ammonium to diphthine-EEF2

Stable Identifier

R-HSA-5358475

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic diphthamide biosynthesis protein 6 (DPH6) ligates an ammonium ion to diphthine-EEF2 to generate diphthamide-EEF2 in a reaction coupled to the hydrolysis of ATP to yield AMP and PPi (Su et al. 2012; Uthman et al. 2013; Wei et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23468660	The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network Uthman, S, Bär, C, Scheidt, V, Liu, S, ten Have, S, Giorgini, F, Stark, MJ, Schaffrath, R	PLoS Genet.	2013
23169644	Chemogenomic approach identified yeast YLR143W as diphthamide synthetase Su, X, Lin, Z, Chen, W, Jiang, H, Zhang, S, Lin, H	Proc. Natl. Acad. Sci. U.S.A.	2012
23486472	A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene Wei, H, Bera, TK, Wayne, AS, Xiang, L, Colantonio, S, Chertov, O, Pastan, I	J. Biol. Chem.	2013