Human dCTP pyrophosphatase 1 (DCTPP1) is a cytosolic enzyme able to hydrolyse deoxynucleoside triphosphates (dNTPs) to their corresponding nucleoside monophosphates. DCTPP1 probably plays a role in protecting DNA or RNA against the incorporation of modified nucleotide triphosphates. Based on mouse studies, Dctpp1 has strong preference for modified dCTPs, with highest activity shown towards 5-iodo-dCTP (5idCTP) (Nonaka et al. 2009). Crystal structures of mouse Dctpp1 suggest it functions as a homotetramer and requires two or three Mg2+ ions per subunit (Wu et al. 2007).
Nakabeppu, Y, Sakumi, K, Nonaka, M, Tsuchimoto, D
Chen, W, Bartlam, M, Wu, B, Rao, Z, Zhang, J, Liao, S, Liu, Y, Zhao, Q
dCTP diphosphatase activity of DCTPP1 tetramer [cytosol]
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