DCTPP1 hydrolyses 5idCTP

Stable Identifier
R-HSA-6786257
Type
Reaction
Species
Homo sapiens
Compartment
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Human dCTP pyrophosphatase 1 (DCTPP1) is a cytosolic enzyme able to hydrolyse deoxynucleoside triphosphates (dNTPs) to their corresponding nucleoside monophosphates. DCTPP1 probably plays a role in protecting DNA or RNA against the incorporation of modified nucleotide triphosphates. Based on mouse studies, Dctpp1 has strong preference for modified dCTPs, with highest activity shown towards 5-iodo-dCTP (5idCTP) (Nonaka et al. 2009). Crystal structures of mouse Dctpp1 suggest it functions as a homotetramer and requires two or three Mg2+ ions per subunit (Wu et al. 2007).

Literature References
PubMed ID Title Journal Year
19220460 Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine

Nakabeppu, Y, Sakumi, K, Nonaka, M, Tsuchimoto, D

FEBS J. 2009
17320107 Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis

Chen, W, Bartlam, M, Wu, B, Rao, Z, Zhang, J, Liao, S, Liu, Y, Zhao, Q

J. Mol. Biol. 2007
Participants
Participates
Catalyst Activity

dCTP diphosphatase activity of DCTPP1 tetramer [cytosol]

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