Reactome | ACSL3,4 ligate CoA to AA to form AA-CoA

ACSL3,4 ligate CoA to AA to form AA-CoA

Stable Identifier

R-HSA-548843

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]

ReviewStatus

5/5

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Acyl-CoA synthetase long-chain family member 4 (ACSL4) associated with the endoplasmic reticulum membrane catalyses the conjugation of arachidonate (AA) with CoA to form arachidonyl-CoA (AA-CoA) (Longo et al. 2003, Meloni et al. 2003). By similarity, ACSL3 can also preferentially conjugate CoA on to AA (Yao & Ye 2008). These enzymes are involved in the activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.

Literature References

PubMed ID	Title	Journal	Year
18003621	Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells Yao, H, Ye, J	J. Biol. Chem.	2008
11889465	FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation Magi, B, des Portes, V, Renieri, A, Yntema, HG, Ropers, HH, Raynaud, M, Longo, I, Meloni, I, Moizard, MP, Chelly, J, Bruttini, M, Schaffer, JE, Bellan, C, Gomot, M, Lewis, SE, Fryns, JP, Muscettola, M, Volpi, N	Nat Genet	2002
12525535	A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients Marynen, P, Meloni, I, Schwartz, C, Ariani, F, Renieri, A, Borghgraef, M, Froyen, G, Raynaud, M, Longo, I, Pescucci, C, Fryns, JP, Frints, SG	J Med Genet	2003