cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate

Stable Identifier
R-HSA-379887
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CARS (cytosolic cysteinyl tRNA synthetase) catalyzes the reaction of cysteine, tRNA(cys), and ATP to form Cys-tRNA(Cys), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homomultimer, probably a dimer (Davidson et al. 2001).

Literature References
PubMed ID Title Journal Year
11347887 Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase

Davidson, E, Caffarella, J, Vitseva, O, Hou, YM, King, MP

Biol Chem 2001
Participants
Participates
Catalyst Activity

cysteine-tRNA ligase activity of CARS dimer [cytosol]

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